Literature DB >> 27089811

Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches.

Dmitriy Khodakov1, Chunyan Wang1, David Yu Zhang2.   

Abstract

Nucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics.
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Keywords:  Hybridization; Molecular diagnostics; Next-generation sequencing; Nucleic acid tests; PCR

Mesh：

Substances：

Year:  2016        PMID： 27089811     DOI： 10.1016/j.addr.2016.04.005

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  28 in total

1.  Multiplexed enrichment of rare DNA variants via sequence-selective and temperature-robust amplification.

Authors:  Lucia R Wu; Sherry X Chen; Yalei Wu; Abhijit A Patel; David Yu Zhang
Journal:  Nat Biomed Eng       Date:  2017-09-04       Impact factor: 25.671

2.  Stoichiometric approach to quantitative analysis of biomolecules: the case of nucleic acids.

Authors:  Adeyinka Adegbenro; Seth Coleman; Irina V Nesterova
Journal:  Anal Bioanal Chem       Date:  2021-11-20       Impact factor: 4.142

3.  High-Throughput Variant Detection Using a Color-Mixing Strategy.

Authors:  Nina G Xie; Kerou Zhang; Ping Song; Renqiang Li; Junfeng Luo; David Y Zhang
Journal:  J Mol Diagn       Date:  2022-06-16       Impact factor: 5.341

4.  High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant.

Authors:  David Y Barefield; Thomas L Lynch; Aravindakshan Jagadeesan; Thriveni Sanagala; Sakthivel Sadayappan
Journal:  J Mol Biomark Diagn       Date:  2016-09-30

5.  Genomic variant annotation workflow for clinical applications.

Authors:  Thomas Thurnherr; Franziska Singer; Daniel J Stekhoven; Niko Beerenwinkel
Journal:  F1000Res       Date:  2016-08-12

6.  Predicting DNA hybridization kinetics from sequence.

Authors:  Jinny X Zhang; John Z Fang; Wei Duan; Lucia R Wu; Angela W Zhang; Neil Dalchau; Boyan Yordanov; Rasmus Petersen; Andrew Phillips; David Yu Zhang
Journal:  Nat Chem       Date:  2017-11-06       Impact factor: 24.427

7.  Establishment of a universal and rational gene detection strategy through three-way junction-based remote transduction.

Authors:  Yidan Tang; Baiyang Lu; Zhentong Zhu; Bingling Li
Journal:  Chem Sci       Date:  2017-11-27       Impact factor: 9.825

8.  Amplification of overlapping DNA amplicons in a single-tube multiplex PCR for targeted next-generation sequencing of BRCA1 and BRCA2.

Authors:  Desiree Schenk; Gang Song; Yue Ke; Zhaohui Wang
Journal:  PLoS One       Date:  2017-07-12       Impact factor: 3.240

9.  Exploratory analysis of introducing next-generation sequencing-based method to treatment-naive lung cancer patients.

Authors:  Yufang Feng; Gaohua Feng; Xiaoling Lu; Wenxia Qian; Junyi Ye; Carmen Areses Manrique; Chunping Ma; Yadong Lu
Journal:  J Thorac Dis       Date:  2018-10       Impact factor: 2.895

10.  Empirical evaluation of methods for de novo genome assembly.

Authors:  Firaol Dida; Gangman Yi
Journal:  PeerJ Comput Sci       Date:  2021-07-09
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