BACKGROUND: Tuberculosis (TB) has reemerged to become the world's leading cause of death from a single infectious agent. Inflammatory cytokines play an important role during the course of the disease and may be responsible for tissue damage by lipid peroxidation. The study was aimed to explore the anti-inflammatory and antioxidant effect of ginger in pulmonary TB patients. METHODS: A total of 69 pulmonary TB patients participated in a randomized and placebo-controlled study. The intervention group received 3 g of ginger extract daily for 1 month and placebo group was supplemented with starch capsule. Participants of both groups were taking standard antitubercular treatment during the study. The concentrations of tumor necrosis factor (TNF) alpha, ferritin and malondialdehyde (MDA) in blood samples were analyzed before and after the intervention by using enzyme-linked immunosorbent assay for TNF alpha and ferritin and spectrophotometry for MDA. RESULTS:Ginger supplementation significantly reduced the levels of TNF alpha, ferritin and MDA in ginger supplemented group in comparison to baseline. Ginger supplementation with antitubercular treatment significantly lowered TNF alpha, ferritin and MDA concentrations in comparison to control group. CONCLUSIONS: Ginger was found to be effective as an anti-inflammatory and antioxidant supplement along with anti-TB therapy as it possesses strong free radical scavenging property.
RCT Entities:
BACKGROUND:Tuberculosis (TB) has reemerged to become the world's leading cause of death from a single infectious agent. Inflammatory cytokines play an important role during the course of the disease and may be responsible for tissue damage by lipid peroxidation. The study was aimed to explore the anti-inflammatory and antioxidant effect of ginger in pulmonary TBpatients. METHODS: A total of 69 pulmonary TBpatients participated in a randomized and placebo-controlled study. The intervention group received 3 g of ginger extract daily for 1 month and placebo group was supplemented with starch capsule. Participants of both groups were taking standard antitubercular treatment during the study. The concentrations of tumor necrosis factor (TNF) alpha, ferritin and malondialdehyde (MDA) in blood samples were analyzed before and after the intervention by using enzyme-linked immunosorbent assay for TNF alpha and ferritin and spectrophotometry for MDA. RESULTS:Ginger supplementation significantly reduced the levels of TNF alpha, ferritin and MDA in ginger supplemented group in comparison to baseline. Ginger supplementation with antitubercular treatment significantly lowered TNF alpha, ferritin and MDA concentrations in comparison to control group. CONCLUSIONS:Ginger was found to be effective as an anti-inflammatory and antioxidant supplement along with anti-TB therapy as it possesses strong free radical scavenging property.
Authors: Nguyen Hoang Anh; Sun Jo Kim; Nguyen Phuoc Long; Jung Eun Min; Young Cheol Yoon; Eun Goo Lee; Mina Kim; Tae Joon Kim; Yoon Young Yang; Eui Young Son; Sang Jun Yoon; Nguyen Co Diem; Hyung Min Kim; Sung Won Kwon Journal: Nutrients Date: 2020-01-06 Impact factor: 5.717
Authors: Arif Khan; Mohd Azam; Masood Alam Khan; Khaled S Allemailem; Faris Alrumaihi; Ahmad Almatroudi; Fahad A Alhumaydhi; Hafiz Iqtidar Ahmad; Masih Uzzaman Khan Journal: Infect Drug Resist Date: 2021-04-21 Impact factor: 4.003
Authors: Leen A Aldwihi; Shahd I Khan; Faisal F Alamri; Yazed AlRuthia; Faleh Alqahtani; Omer I Fantoukh; Ahmed Assiri; Omar A Almohammed Journal: Int J Environ Res Public Health Date: 2021-05-11 Impact factor: 3.390