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Literature DB >> 27088072

Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery.

Abstract

This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies. Overview of drug delivery systems targeted to cancers that overexpress CXCR4 is provided, together with the main types of CXCR4-binding ligands used in targeting applications. Drug delivery applications that take advantage of CXCR4 inhibition to achieve enhanced anticancer and antimetastatic activity of combination treatments are also discussed.

Entities: CellLine Chemical Disease Gene Species

Keywords: CXCR4; cancer; drug delivery; gene delivery; metastasis; nanoparticles; siRNA delivery

Year: 2016 PMID： 27088072 PMCID： PMC4827436 DOI： 10.1007/s40495-015-0044-8

Source DB: PubMed Journal: Curr Pharmacol Rep ISSN： 2198-641X

76 in total

Review 1. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease.

Authors: Yingying Le; Ye Zhou; Pablo Iribarren; Jiming Wang
Journal: Cell Mol Immunol Date: 2004-04 Impact factor: 11.530

2. The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study.

Authors: Ombretta Salvucci; Amélie Bouchard; Andrea Baccarelli; Jean Deschênes; Guido Sauter; Ronald Simon; Rosella Bianchi; Mark Basik
Journal: Breast Cancer Res Treat Date: 2005-12-13 Impact factor: 4.872

3. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways.

Authors: R K Ganju; S A Brubaker; J Meyer; P Dutt; Y Yang; S Qin; W Newman; J E Groopman
Journal: J Biol Chem Date: 1998-09-04 Impact factor: 5.157

Review 4. The chemokine system and cancer.

Authors: Frances R Balkwill
Journal: J Pathol Date: 2011-11-23 Impact factor: 7.996

5. The structure of monomeric components of self-assembling CXCR4 antagonists determines the architecture of resulting nanostructures.

Authors: Youngshim Lee; Yuhong Chen; Nadya I Tarasova; Vadim Gaponenko
Journal: Nanotechnology Date: 2011-11-23 Impact factor: 3.874

6. Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C.

Authors: J F Wang; I W Park; J E Groopman
Journal: Blood Date: 2000-04-15 Impact factor: 22.113

7. CXCR4 regulates growth of both primary and metastatic breast cancer.

Authors: Matthew C P Smith; Kathryn E Luker; Joel R Garbow; Julie L Prior; Erin Jackson; David Piwnica-Worms; Gary D Luker
Journal: Cancer Res Date: 2004-12-01 Impact factor: 12.701

8. Using breast cancer cell CXCR4 surface expression to predict liposome binding and cytotoxicity.

Authors: Peng Guo; Jin-Oh You; Jiang Yang; Marsha A Moses; Debra T Auguste
Journal: Biomaterials Date: 2012-08-09 Impact factor: 12.479

9. Immunoimaging of CXCR4 expression in brain tumor xenografts using SPECT/CT.

Authors: Sridhar Nimmagadda; Mrudula Pullambhatla; Martin G Pomper
Journal: J Nucl Med Date: 2009-06-12 Impact factor: 10.057

10. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.

Authors: Yunching Chen; Yuhui Huang; Thomas Reiberger; Annique M Duyverman; Peigen Huang; Rekha Samuel; Lotte Hiddingh; Sylvie Roberge; Christina Koppel; Gregory Y Lauwers; Andrew X Zhu; Rakesh K Jain; Dan G Duda
Journal: Hepatology Date: 2014-02-18 Impact factor: 17.425

19 in total

1. Autocatalytic Delivery of Brain Tumor-targeting, Size-shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases.

Authors: Shenqi Zhang; Gang Deng; Fuyao Liu; Bin Peng; Youmei Bao; Fengyi Du; Ann T Chen; Jun Liu; Zeming Chen; Junning Ma; Xiangjun Tang; Qianxue Chen; Jiangbing Zhou
Journal: Adv Funct Mater Date: 2020-02-20 Impact factor: 18.808

2. A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4.

Authors: Geert Schoofs; Anneleen Van Hout; Thomas D'huys; Dominique Schols; Tom Van Loy
Journal: J Vis Exp Date: 2018-03-10 Impact factor: 1.355

Review 3. Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer.

Authors: Ying Xie; Yazhe Wang; Jing Li; Yu Hang; David Oupický
Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol Date: 2018-04-26

10. Serum SDF-1 levels are a reliable diagnostic marker of feline mammary carcinoma, discriminating HER2-overexpressing tumors from other subtypes.

Authors: Cláudia S Marques; Maria Soares; Ana Santos; Jorge Correia; Fernando Ferreira
Journal: Oncotarget Date: 2017-11-11