Saya Nagai1, Toshifumi Kudo2, Yoshinori Inoue3, Miho Akaza1, Tetsuo Sasano1, Yuki Sumi1. 1. Biofunctional Informatics, Biomedical Laboratory Sciences, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 2. Department of Professional Development, Tokyo Medical and Dental University, Tokyo, Japan; Division of Peripheral Vascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan. 3. Division of Peripheral Vascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Abstract
OBJECTIVE: This study aimed to clarify long-term mortality and its predictors in patients with abdominal aortic aneurysm (AAA) who underwent endovascular aneurysm repair (EVAR). MATERIALS AND METHODS: Patients with AAA who underwent elective EVAR at Tokyo Medical and Dental University hospital between 2008 and 2011 were reviewed. The patients' data were retrospectively collected from medical records. RESULTS: Sixty-four patients were identified for this study. In long-term follow-up, the survival rate was significantly lower in patients with high preoperative C-reactive protein (CRP) levels. Patients with obstructive lung disease (FEV1/FVC <70%) or anemia tended to have a poorer prognosis but the association was not statistically significant. Age, concurrent hyperlipidemia, and blood pressure levels were not predictors of mortality rates. DISCUSSION: High CRP level, COPD, and anemia reflect inflammation, which is associated with the pathogenesis of AAA. These inflammatory markers are predictors of long-term mortality after EVAR for AAA as well as for other diseases. CONCLUSIONS: A high preoperative CRP level was a predictor of increased long-term mortality in patients with AAA who underwent EVAR. No specific leading causes of death were identified for this increase in the mortality rate.
OBJECTIVE: This study aimed to clarify long-term mortality and its predictors in patients with abdominal aortic aneurysm (AAA) who underwent endovascular aneurysm repair (EVAR). MATERIALS AND METHODS:Patients with AAA who underwent elective EVAR at Tokyo Medical and Dental University hospital between 2008 and 2011 were reviewed. The patients' data were retrospectively collected from medical records. RESULTS: Sixty-four patients were identified for this study. In long-term follow-up, the survival rate was significantly lower in patients with high preoperative C-reactive protein (CRP) levels. Patients with obstructive lung disease (FEV1/FVC <70%) or anemia tended to have a poorer prognosis but the association was not statistically significant. Age, concurrent hyperlipidemia, and blood pressure levels were not predictors of mortality rates. DISCUSSION: High CRP level, COPD, and anemia reflect inflammation, which is associated with the pathogenesis of AAA. These inflammatory markers are predictors of long-term mortality after EVAR for AAA as well as for other diseases. CONCLUSIONS: A high preoperative CRP level was a predictor of increased long-term mortality in patients with AAA who underwent EVAR. No specific leading causes of death were identified for this increase in the mortality rate.
Authors: F L Moll; J T Powell; G Fraedrich; F Verzini; S Haulon; M Waltham; J A van Herwaarden; P J E Holt; J W van Keulen; B Rantner; F J V Schlösser; F Setacci; J-B Ricco Journal: Eur J Vasc Endovasc Surg Date: 2011-01 Impact factor: 7.069
Authors: Lina J Leurs; Patrice Visser; Robert J F Laheij; Jaap Buth; Peter L H Harris; Jan D Blankensteijn Journal: Vascular Date: 2006 Jan-Feb Impact factor: 1.285
Authors: Raimund Erbel; Victor Aboyans; Catherine Boileau; Eduardo Bossone; Roberto Di Bartolomeo; Holger Eggebrecht; Arturo Evangelista; Volkmar Falk; Herbert Frank; Oliver Gaemperli; Martin Grabenwöger; Axel Haverich; Bernard Iung; Athanasios John Manolis; Folkert Meijboom; Christoph A Nienaber; Marco Roffi; Hervé Rousseau; Udo Sechtem; Per Anton Sirnes; Regula S von Allmen; Christiaan J M Vrints Journal: Eur Heart J Date: 2014-08-29 Impact factor: 29.983
Authors: Joseph V Moxon; Adam Parr; Theophilus I Emeto; Philip Walker; Paul E Norman; Jonathan Golledge Journal: Curr Probl Cardiol Date: 2010-10 Impact factor: 5.200
Authors: Brendan Wisniowski; Mary Barnes; Jason Jenkins; Nicholas Boyne; Allan Kruger; Philip J Walker Journal: J Vasc Surg Date: 2011-07-23 Impact factor: 4.268
Authors: Dilyara G Yanbaeva; Mieke A Dentener; Eva C Creutzberg; Geertjan Wesseling; Emiel F M Wouters Journal: Chest Date: 2007-05 Impact factor: 9.410
Authors: Matthew Scott-Young; Laurence McEntee; James Furness; Ben Schram; Wayne Hing; David Grosser; Mario Zotti Journal: Int J Spine Surg Date: 2018-08-15