Literature DB >> 27086654

A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems.

Sonia De Angelis1, Maddalena De Renzo1, Claudia Carlucci1, Leonardo Degennaro1, Renzo Luisi1.   

Abstract

A convenient, versatile, and green CBS-asymmetric reduction of aryl and heteroaryl ketones has been developed by using the microreactor technology. The study demonstrates that it is possible to handle borane solution safely within microreactors and that the reaction performs well using 2-MeTHF as a greener solvent.

Entities:  

Year:  2016        PMID： 27086654     DOI： 10.1039/c6ob00336b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

Review 1.  Replacement of Less-Preferred Dipolar Aprotic and Ethereal Solvents in Synthetic Organic Chemistry with More Sustainable Alternatives.

Authors:  Andrew Jordan; Callum G J Hall; Lee R Thorp; Helen F Sneddon
Journal:  Chem Rev       Date:  2022-02-24       Impact factor: 72.087

Review 2.  Recent advancements on the use of 2-methyltetrahydrofuran in organometallic chemistry.

Authors:  Serena Monticelli; Laura Castoldi; Irene Murgia; Raffaele Senatore; Eugenia Mazzeo; Judith Wackerlig; Ernst Urban; Thierry Langer; Vittorio Pace
Journal:  Monatsh Chem       Date:  2016-12-07       Impact factor: 1.451

3.  Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor.

Authors:  Li-Hua Du; Jia-Hong Shen; Zhen Dong; Na-Ni Zhou; Bing-Zhuo Cheng; Zhi-Min Ou; Xi-Ping Luo
Journal:  RSC Adv       Date:  2018-04-03       Impact factor: 4.036

Review 4.  Application of Biobased Solvents in Asymmetric Catalysis.

Authors:  Margherita Miele; Veronica Pillari; Vittorio Pace; Andrés R Alcántara; Gonzalo de Gonzalo
Journal:  Molecules       Date:  2022-10-08       Impact factor: 4.927

5.  Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex.

Authors:  Sándor B Ötvös; C Oliver Kappe
Journal:  ChemSusChem       Date:  2020-02-20       Impact factor: 8.928

6.  Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis.

Authors:  Sándor B Ötvös; Miquel A Pericàs; C Oliver Kappe
Journal:  Chem Sci       Date:  2019-10-18       Impact factor: 9.825
  6 in total

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