Francesca Assogna1, Luca Cravello2, Maria Donata Orfei1, Nystya Cellupica1, Carlo Caltagirone3, Gianfranco Spalletta4. 1. I.R.C.C.S. Santa Lucia Foundation, Rome, Italy. 2. I.R.C.C.S. Santa Lucia Foundation, Rome, Italy; ASST-Rhodense, Rho, Milan, Italy. 3. I.R.C.C.S. Santa Lucia Foundation, Rome, Italy; Department of Medicine of Systems, University "Tor Vergata", Rome, Italy. 4. I.R.C.C.S. Santa Lucia Foundation, Rome, Italy. Electronic address: g.spalletta@hsantalucia.it.
Abstract
INTRODUCTION: In this systematic review, we aimed to evaluate the role of alexithymia in Parkinson's disease (PD) and its relationship to neurological, neuropsychiatric, cognitive, and neuroimaging correlates. METHODS: The database was selected using PubMed Services, Cochrane, PsycNET and Scopus and a number of key words. Further studies were sought by manually searching for secondary sources, including relevant journals and references in primary articles. The search was restricted to articles written in English between January 1980 and August 2015. RESULTS: Ten studies reported that alexithymia prevalence was about double in PD patients compared to control subjects and that specific dimensions of alexithymia might be related to depression, anxiety, apathy and impulsivity. Some studies investigated the relationship between alexithymia and neuropsychological symptoms and found correlations with frontal and parietal lobe functions. Two studies on neurological features reported a link between alexithymia and disease stage or a specific motor subtype of PD; the remaining studies found that alexithymia was independent from neurological symptoms, dopaminergic therapy and laterality of motor symptom onset. Data on neuroimaging correlates and therapeutic intervention on alexithymia in PD patients are still lacking. CONCLUSION: Although results suggest that alexithymia is a primary characteristics of PD, further studies with larger patient samples are needed to definitively clarify the impact of alexithymia on the clinical features of PD patients.
INTRODUCTION: In this systematic review, we aimed to evaluate the role of alexithymia in Parkinson's disease (PD) and its relationship to neurological, neuropsychiatric, cognitive, and neuroimaging correlates. METHODS: The database was selected using PubMed Services, Cochrane, PsycNET and Scopus and a number of key words. Further studies were sought by manually searching for secondary sources, including relevant journals and references in primary articles. The search was restricted to articles written in English between January 1980 and August 2015. RESULTS: Ten studies reported that alexithymia prevalence was about double in PDpatients compared to control subjects and that specific dimensions of alexithymia might be related to depression, anxiety, apathy and impulsivity. Some studies investigated the relationship between alexithymia and neuropsychological symptoms and found correlations with frontal and parietal lobe functions. Two studies on neurological features reported a link between alexithymia and disease stage or a specific motor subtype of PD; the remaining studies found that alexithymia was independent from neurological symptoms, dopaminergic therapy and laterality of motor symptom onset. Data on neuroimaging correlates and therapeutic intervention on alexithymia in PDpatients are still lacking. CONCLUSION: Although results suggest that alexithymia is a primary characteristics of PD, further studies with larger patient samples are needed to definitively clarify the impact of alexithymia on the clinical features of PDpatients.
Authors: Jonathan Del-Monte; Sophie Bayard; Pierluigi Graziani; Marie C Gély-Nargeot Journal: Front Behav Neurosci Date: 2017-11-21 Impact factor: 3.558
Authors: Marta Szepietowska; Alicja Dąbrowska; Bernadetta Nowak; Katarzyna Skinderowicz; Bartosz Wilczyński; Piotr K Krajewski; Alina Jankowska-Konsur Journal: J Clin Med Date: 2022-01-29 Impact factor: 4.241