Chamidri Naotunna1, Suneth Buddhika Agampodi2, Thilini Chanchala Agampodi1. 1. Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura 50008, Sri Lanka. 2. Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura 50008, Sri Lanka. Electronic address: sunethagampodi@yahoo.com.
Abstract
OBJECTIVE: To systematically review the etiological agent causing human leptospirosis in Sri Lanka. METHODS: Published articles on leptospirosis and Leptospira in Sri Lanka were all reviewed to determine serovar, strain and species level identification of Leptospira. After screening process, 74 full text articles/reports were reviewed and among of them, 12 published papers describing isolation of Leptospira from Sri Lankan patients/animals, 5 molecular epidemiology papers on newer typing methods citing Sri Lanka isolates, with a descriptions of the isolates and 6 published papers reporting PCR based species level identification were identified. RESULTS: Published literature showed that more than 40 strains classified under at least 20 serovars and 10 serogroups have been isolated from Sri Lanka. These isolates belong to four species, namely, Leptospira interrogans, Leptospira kirschneri, Leptospira borgpetersenii, and Leptospira santarosai. In addition, recent studies on direct patient samples without culture and isolation showed Leptospira from Leptospira weilli is also circulating in Sri Lanka. Multi locus sequence typing showed 13 genotypes of Leptospira from Sri Lankan isolates. CONCLUSIONS: This review shows the diversity of Leptospira in Sri Lanka, but culture isolation data has not been published in Sri Lanka during last 30 years.
OBJECTIVE: To systematically review the etiological agent causing humanleptospirosis in Sri Lanka. METHODS: Published articles on leptospirosis and Leptospira in Sri Lanka were all reviewed to determine serovar, strain and species level identification of Leptospira. After screening process, 74 full text articles/reports were reviewed and among of them, 12 published papers describing isolation of Leptospira from Sri Lankan patients/animals, 5 molecular epidemiology papers on newer typing methods citing Sri Lanka isolates, with a descriptions of the isolates and 6 published papers reporting PCR based species level identification were identified. RESULTS: Published literature showed that more than 40 strains classified under at least 20 serovars and 10 serogroups have been isolated from Sri Lanka. These isolates belong to four species, namely, Leptospira interrogans, Leptospira kirschneri, Leptospira borgpetersenii, and Leptospira santarosai. In addition, recent studies on direct patient samples without culture and isolation showed Leptospira from Leptospira weilli is also circulating in Sri Lanka. Multi locus sequence typing showed 13 genotypes of Leptospira from Sri Lankan isolates. CONCLUSIONS: This review shows the diversity of Leptospira in Sri Lanka, but culture isolation data has not been published in Sri Lanka during last 30 years.
Authors: N D B Ehelepola; Kusalika Ariyaratne; A M S M C M Aththanayake; Kamalanath Samarakoon; H M Arjuna Thilakarathna Journal: Trop Med Health Date: 2021-05-26
Authors: Bruno Alonso Miotto; Aline Gil Alves Guilloux; Barbara Furlan Tozzi; Luisa Zanolli Moreno; Aline Santana da Hora; Ricardo Augusto Dias; Marcos Bryan Heinemann; Andrea Micke Moreno; Antônio Francisco de Souza Filho; Walter Lilenbaum; Mitika Kuribayashi Hagiwara Journal: PLoS One Date: 2018-07-11 Impact factor: 3.240