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Literature DB >> 27086

The effect of cyclophosphamide and methotrexate on the 'field effect' or unresponsiveness observed in the rat and mouse GvHR.

Abstract

The Field effect is the decreased biological response to a second challenge in the graft versus host reaction (GvHR). Treatment of recipeint rats or mice during the initial GvHR by methotrexate or cyclophosphamide effected the secondary unresponsivienss. Methotrexate and cyclophosphamide demonstrated different temporal responses indicating different mechanisms of their immunosuppresdive activities.

Entities: Chemical Species

Mesh：

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Year: 1975 PMID： 27086 DOI： 10.1007/BF02026442

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

24 in total

1. An acquired type of refractoriness to graft-versus-host reaction in adult F1 hybrid mice.

Authors: M FOX; J G HOWARD
Journal: Transplantation Date: 1963-01 Impact factor: 4.939

2. Specific and nonspecific lymphoid cell proliferation in the pathogenesis of graft-versus-host reactions.

Authors: W L Elkins
Journal: Transplantation Date: 1970-03 Impact factor: 4.939

3. A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells.

Authors: W L Ford; W Burr; M Simonsen
Journal: Transplantation Date: 1970-09 Impact factor: 4.939

4. A common pathogenesis for the lesions of graft-versus-host disease.

Authors: J W Streilein
Journal: Transplant Proc Date: 1971-03 Impact factor: 1.066

5. Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1 hybrid rats.

Authors: W L Ford; R C Atkins
Journal: Nat New Biol Date: 1971-12-08

6. Ability of splenic lymphocytes from injured rats to induce a graft-versus-host reaction.

Authors: A M Munster; K Eurenius; R F Mortensen; A D Mason
Journal: Transplantation Date: 1972-07 Impact factor: 4.939

7. Differential effects of cyclophosphamide on the B and T cell compartments of adult mice.

Authors: G D Stockman; L R Heim; M A South; J J Trentin
Journal: J Immunol Date: 1973-01 Impact factor: 5.422

8. Local and regional forms of graft-versus-host disease in lymph nodes.

Authors: S Levine
Journal: Transplantation Date: 1968-09 Impact factor: 4.939

9. Activities of immunosuppressive agents in vitro. II. Different timing of azathioprine and methotrexate in inhibition and stimulation of mixed lymphocyte reaction.

Authors: M A Bach; J F Bach
Journal: Clin Exp Immunol Date: 1972-05 Impact factor: 4.330