Serife Ozdinc1, Ebru Unlu2, Zeynep Karakaya3, Ozan Turamanlar4, Nurhan Dogan5, Yesim Isler6, Yucel Gonul7, Mehmet Gazi Boyaci8. 1. Afyon Kocatepe University, School of Medicine, Department of Emergency Medicine, Afyonkarahisar, Turkey. Electronic address: drseri03@hotmail.com. 2. Afyon Kocatepe University, School of Medicine, Department of Radiology, Afyonkarahisar, Turkey. Electronic address: eunlu@gmail.com. 3. İzmir Katip Celebi University, Atatürk Training and Research Hospital, Clinic of Emergency Medicine, Izmir, Turkey. Electronic address: zkarakaya@gmail.com. 4. Afyon Kocatepe University, School of Medicine, Department of Anatomy, Afyonkarahisar, Turkey. Electronic address: ozantrmnlr@gmail.com. 5. Afyon Kocatepe University, School of Medicine, Department of Biostatistics and Medical Informatics, Afyonkarahisar, Turkey. Electronic address: nurhandogan@hotmail.com. 6. Bursa Yuksek Ihtisas Training and Research Hospital, Clinic of Emergency Medicine, Bursa, Turkey. Electronic address: dryesim77@yahoo.com. 7. Afyon Kocatepe University, School of Medicine, Department of Anatomy, Afyonkarahisar, Turkey. Electronic address: yucel94@hotmail.com. 8. Afyon Kocatepe University, School of Medicine, Department of Neurosurgery, Afyonkarahisar, Turkey. Electronic address: drmgzbyc@hotmail.com.
Abstract
OBJECTIVE: Intracerebral hemorrhage (ICH) is a potentially life-threatening condition. Interventions and treatments should be managed on time to reduce mortality. It has been put forth that perihematomal edema absolute volume (PHEAV) is related to mortality, however the effect of perihematomal edema absolute area (PHEAA) on mortality is unknown. The objective of this study was to evaluate the effect of PHEAA on 30-day mortality in patients with ICH. METHODS: Patients were screened with ICD-9, retrospectively. 106 patients were included in the study. Clinical data were obtained from the patient files. Computed tomography (CT) was acquired from the hospital imaging database. PHEAV and PHEAA were measured via CT by two clinicians blinded to the study protocol. The predictors of 30- day mortality were examined. RESULTS: Forty-three (40.6%) patients died within 30days. Older age, lack of trauma, low Glasgow coma scale and high blood glucose were associated with high mortality (P≤.001). PHEAV and PHEAA values were higher in nonsurvivors (P<.001). PHEAA was detected as an independent predictor of 30-day mortality. The cutoff value of PHEAA for mortality was 33.41cm(2) (sensitivity: 84.4%, specificity: 59.0%). There was no difference between receiver operating characteristic curves of PHEAA and PHEAV (P=.55). CONCLUSION: In contrast to PHEAV, PHEAA is a simple value which can be measured without the requirement of any additional techniques or extra costs which can be quickly applied and which is an independent indicator of 30-day mortality. PHEAA can accelerate physician interventions for patients with ICH within several hours of ED admission.
OBJECTIVE:Intracerebral hemorrhage (ICH) is a potentially life-threatening condition. Interventions and treatments should be managed on time to reduce mortality. It has been put forth that perihematomal edema absolute volume (PHEAV) is related to mortality, however the effect of perihematomal edema absolute area (PHEAA) on mortality is unknown. The objective of this study was to evaluate the effect of PHEAA on 30-day mortality in patients with ICH. METHODS:Patients were screened with ICD-9, retrospectively. 106 patients were included in the study. Clinical data were obtained from the patient files. Computed tomography (CT) was acquired from the hospital imaging database. PHEAV and PHEAA were measured via CT by two clinicians blinded to the study protocol. The predictors of 30- day mortality were examined. RESULTS: Forty-three (40.6%) patients died within 30days. Older age, lack of trauma, low Glasgow coma scale and high blood glucose were associated with high mortality (P≤.001). PHEAV and PHEAA values were higher in nonsurvivors (P<.001). PHEAA was detected as an independent predictor of 30-day mortality. The cutoff value of PHEAA for mortality was 33.41cm(2) (sensitivity: 84.4%, specificity: 59.0%). There was no difference between receiver operating characteristic curves of PHEAA and PHEAV (P=.55). CONCLUSION: In contrast to PHEAV, PHEAA is a simple value which can be measured without the requirement of any additional techniques or extra costs which can be quickly applied and which is an independent indicator of 30-day mortality. PHEAA can accelerate physician interventions for patients with ICH within several hours of ED admission.
Authors: Muhammad E Haque; Refaat E Gabr; Sarah D George; Xiurong Zhao; Seth B Boren; Xu Zhang; Shun-Ming Ting; Gunghua Sun; Khader M Hasan; Sean Savitz; Jaroslaw Aronowski Journal: Front Neurosci Date: 2019-08-21 Impact factor: 4.677
Authors: James Jm Loan; Angus B Gane; Laura Middleton; Brendan Sargent; Tom James Moullaali; Mark A Rodrigues; Laura Cunningham; Joanna Wardlaw; Rustam Al-Shahi Salman; Neshika Samarasekera Journal: Int J Stroke Date: 2020-11-25 Impact factor: 5.266