Levent Kilic1, Abdulsamet Erden2, Clifton O Bingham2, Laure Gossec2, Umut Kalyoncu2. 1. From the Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Ankara, Turkey; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS); Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital, Paris, France.L. Kilic, MD, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University; A. Erden, MD, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University; C.O. Bingham III, MD, Professor, Division of Rheumatology, Department of Medicine, Johns Hopkins University; L. Gossec, MD, Professor, Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS), and Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital; U. Kalyoncu, MD, Associate Professor, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University, and Division of Rheumatology, Department of Medicine, Johns Hopkins University. drleventkilic@yahoo.com. 2. From the Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Ankara, Turkey; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS); Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital, Paris, France.L. Kilic, MD, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University; A. Erden, MD, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University; C.O. Bingham III, MD, Professor, Division of Rheumatology, Department of Medicine, Johns Hopkins University; L. Gossec, MD, Professor, Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS), and Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital; U. Kalyoncu, MD, Associate Professor, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University, and Division of Rheumatology, Department of Medicine, Johns Hopkins University.
Abstract
OBJECTIVE: Patient-reported outcomes (PRO) in rheumatoid arthritis (RA) provide important information regarding disease effect. The study objective was to assess the frequency of PRO use in recent RA studies and compare results with a previous systematic review (SR) in 2005-2007. METHODS: An SR was performed in PubMed MEDLINE (January 2015). Publications were identified using these MEdical Subject Headings terms: "arthritis, rheumatoid" with a limitation to "humans," "all adults: 19+ years," "English," "published in the last 2 years," and "clinical trials." All studies were assessed, whatever their designs. All PRO reported in publications were classified according to general domains of health by 2 authors. Statistics were descriptive. RESULTS: Two hundred fifty articles were analyzed. Of them, 113 (45.2%) were randomized controlled trials; 138 different PRO were reported. The most frequent PRO, similar to the 2007 SR, were function (68.0%), pain (40.0%), patient's global assessment (49.2%), and health-related quality of life (18.4%). Fatigue (14.4%), morning stiffness (10.0%), psychological status (9.6%), productivity losses (6.4%), utility (5.2%), sleep disturbance (2.4%), and coping (2.0%) were rarely reported. Although frequent domains were reported using well-validated questionnaires, the others were reported using heterogeneous questionnaires. CONCLUSION: The PRO collected and reported in RA studies are remarkably consistent with those seen in 2005-2007, and reflect the existing RA Core Set measures. Other domains of health prioritized by patients including fatigue, psychological status, productivity losses, sleep disturbance, and coping remain rarely reported. Further, heterogeneity in outcome measures used presents challenges in interpreting true disease effect and response to therapy.
OBJECTIVE:Patient-reported outcomes (PRO) in rheumatoid arthritis (RA) provide important information regarding disease effect. The study objective was to assess the frequency of PRO use in recent RA studies and compare results with a previous systematic review (SR) in 2005-2007. METHODS: An SR was performed in PubMed MEDLINE (January 2015). Publications were identified using these MEdical Subject Headings terms: "arthritis, rheumatoid" with a limitation to "humans," "all adults: 19+ years," "English," "published in the last 2 years," and "clinical trials." All studies were assessed, whatever their designs. All PRO reported in publications were classified according to general domains of health by 2 authors. Statistics were descriptive. RESULTS: Two hundred fifty articles were analyzed. Of them, 113 (45.2%) were randomized controlled trials; 138 different PRO were reported. The most frequent PRO, similar to the 2007 SR, were function (68.0%), pain (40.0%), patient's global assessment (49.2%), and health-related quality of life (18.4%). Fatigue (14.4%), morning stiffness (10.0%), psychological status (9.6%), productivity losses (6.4%), utility (5.2%), sleep disturbance (2.4%), and coping (2.0%) were rarely reported. Although frequent domains were reported using well-validated questionnaires, the others were reported using heterogeneous questionnaires. CONCLUSION: The PRO collected and reported in RA studies are remarkably consistent with those seen in 2005-2007, and reflect the existing RA Core Set measures. Other domains of health prioritized by patients including fatigue, psychological status, productivity losses, sleep disturbance, and coping remain rarely reported. Further, heterogeneity in outcome measures used presents challenges in interpreting true disease effect and response to therapy.
Authors: Laure Gossec; John Richard Kirwan; Maarten de Wit; Andra Balanescu; Cecile Gaujoux-Viala; Francis Guillemin; Anne-Christine Rat; Alain Saraux; Bruno Fautrel; Tore K Kvien; Maxime Dougados Journal: Clin Rheumatol Date: 2018-02-21 Impact factor: 2.980
Authors: Elena Nikiphorou; Helga Radner; Katerina Chatzidionysiou; Carole Desthieux; Codruta Zabalan; Yvonne van Eijk-Hustings; William G Dixon; Kimme L Hyrich; Johan Askling; Laure Gossec Journal: Arthritis Res Ther Date: 2016-10-28 Impact factor: 5.156
Authors: Eduardo José Ferreira Santos; Cátia Duarte; Ricardo J O Ferreira; Ana Margarida Pinto; Rinie Geenen; Jose A P da Silva Journal: Ann Rheum Dis Date: 2018-04-06 Impact factor: 19.103
Authors: Generoso Guerra Bautista; Ricardo Machado Xavier; Maria de la Vega; J Abraham Simón-Campos; Gastón Solano; Ronald D Pedersen; Bonnie Vlahos; Cecilia Borlenghi Journal: Open Access Rheumatol Date: 2019-12-12