Literature DB >> 27084535

Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway.

Zhiwei Zhang1, Cindy X Cai2.   

Abstract

The expression of kidney injury molecule-1 (KIM-1), a very promising sensitive and specific urinary biomarker for acute renal injury, is markedly upregulated in injured and regenerating renal proximal tubular epithelial cells following ischemic or toxic insults, suggesting a possible role for this molecule in renal repair process. In the present study, we report that expression of KIM-1 facilitates renal tubular epithelial cell repair by promoting cell migration and proliferation. KIM-1 expression also enhances ERK MAPK activation, and the modulatory effect of KIM-1 on cellular repair process is likely mediated via ERK MAPK signaling pathway.

Entities:  

Keywords:  Cell migration; Cell proliferation; Cellular repair; ERK MAPK; Kidney injury molecule-1 (KIM-1)

Mesh：

Substances：

Year:  2016        PMID： 27084535      PMCID： PMC4883006          DOI： 10.1007/s11010-016-2700-7

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


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