Mario García-Carrasco1, Claudia Mendoza-Pinto2, Ivet Etchegaray-Morales3, Pamela Soto-Santillán3, Erick Alejandro Jiménez-Herrera3, Viridiana Robles-Sánchez3, Alma Rodríguez-Gallegos4, Araceli Ramos-Varela3, Margarita Muñoz-Guarneros5, Alejandro Ruiz-Argüelles6. 1. Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional N.(o) 36, Instituto Mexicano del Seguro Social, Puebla, México; Departamento de Reumatología e Inmunología, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, México. Electronic address: mgc30591@yahoo.com. 2. Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional N.(o) 36, Instituto Mexicano del Seguro Social, Puebla, México; Departamento de Reumatología e Inmunología, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, México. 3. Unidad de Investigación de Enfermedades Autoinmunes Sistémicas, Hospital General Regional N.(o) 36, Instituto Mexicano del Seguro Social, Puebla, México. 4. Laboratorios Clínicos de Puebla, Puebla, México. 5. Secretaría de Estudios de Posgrado e Investigación, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, México. 6. Laboratorios Clínicos de Puebla, Puebla, México; Universidad de las Américas Puebla, Puebla, México.
Abstract
OBJECTIVES: To determine and compare the prevalence of vitamin D insufficiency and deficiency in patients with systemic lupus erythematosus (SLE) with and without disease activity. PATIENTS AND METHODS: We made a comparative, observational, cross-sectional, prospective study of 137 women with SLE according to American College of Rheumatology criteria. Patients with chronic kidney disease, cancer, hyperparathyroidism, pregnancy, and lactation were excluded. Disease activity was assessed using the MEX-SLEDAI score: a score of ≥3 was considered as disease activity. Data were collected on diabetes mellitus, the use of corticosteroids, chloroquine, and immunosuppressants, photoprotection and vitamin D supplementation. Vitamin D levels were measured by chemiluminescent immunoassay: insufficiency was defined as serum 25-hydroxyvitamin D <30ng/ml and deficiency as <10ng/ml. RESULTS: 137 women with SLE (mean age 45.9±11.6 years, disease duration 7.7±3.4 years) were evaluated. Mean disease activity was 2 (0-8): 106 patients had no disease activity and 31 had active disease (77.4% versus 22.6%). Vitamin D insufficiency and deficiency was found in 122(89.0%) and 4 (2.9%) patients, respectively. There was no significant difference in vitamin D levels between patients with and without active disease (19.3±4.5 versus 19.7±6.8; P=.75). No correlation between the MEX-SLEDAI score (P=.21), photosensitivity, photoprotection, prednisone or chloroquine use and vitamin D supplementation was found. CONCLUSIONS: Women with SLE had a high prevalence of vitamin D insufficient. No association between vitamin D levels and disease activity was found.
OBJECTIVES: To determine and compare the prevalence of vitamin Dinsufficiency and deficiency in patients with systemic lupus erythematosus (SLE) with and without disease activity. PATIENTS AND METHODS: We made a comparative, observational, cross-sectional, prospective study of 137 women with SLE according to American College of Rheumatology criteria. Patients with chronic kidney disease, cancer, hyperparathyroidism, pregnancy, and lactation were excluded. Disease activity was assessed using the MEX-SLEDAI score: a score of ≥3 was considered as disease activity. Data were collected on diabetes mellitus, the use of corticosteroids, chloroquine, and immunosuppressants, photoprotection and vitamin D supplementation. Vitamin D levels were measured by chemiluminescent immunoassay: insufficiency was defined as serum 25-hydroxyvitamin D <30ng/ml and deficiency as <10ng/ml. RESULTS: 137 women with SLE (mean age 45.9±11.6 years, disease duration 7.7±3.4 years) were evaluated. Mean disease activity was 2 (0-8): 106 patients had no disease activity and 31 had active disease (77.4% versus 22.6%). Vitamin Dinsufficiency and deficiency was found in 122(89.0%) and 4 (2.9%) patients, respectively. There was no significant difference in vitamin D levels between patients with and without active disease (19.3±4.5 versus 19.7±6.8; P=.75). No correlation between the MEX-SLEDAI score (P=.21), photosensitivity, photoprotection, prednisone or chloroquine use and vitamin D supplementation was found. CONCLUSIONS:Women with SLE had a high prevalence of vitamin D insufficient. No association between vitamin D levels and disease activity was found.
Authors: Mónica R Meza-Meza; José Francisco Muñoz-Valle; Adolfo I Ruiz-Ballesteros; Barbara Vizmanos-Lamotte; Isela Parra-Rojas; Erika Martínez-López; Edith Oregon-Romero; Yolanda Fabiola Márquez-Sandoval; Sergio Cerpa-Cruz; Ulises de la Cruz-Mosso Journal: J Immunol Res Date: 2021-12-31 Impact factor: 4.818