Junko Ishii1, Nobuhiro Yuki2, Michi Kawamoto3, Hajime Yoshimura4, Susumu Kusunoki5, Nobuo Kohara6. 1. Department of Neurology, Kobe City Medical Center General Hospital, Japan. Electronic address: ishii-j@kcho.jp. 2. Brain and Mind Centre, University of Sydney, Australia. Electronic address: gbs.yuki.cidp@gmail.com. 3. Department of Neurology, Kobe City Medical Center General Hospital, Japan. Electronic address: kawamoto@kcho.jp. 4. Department of Neurology, Kobe City Medical Center General Hospital, Japan. Electronic address: hajime-y@kcho.jp. 5. Department of Neurology, Kinki University School of Medicine, Japan. Electronic address: kusunoki-tky@umin.ac.jp. 6. Department of Neurology, Kobe City Medical Center General Hospital, Japan. Electronic address: kohara-kcgh@umin.ac.jp.
Abstract
OBJECTIVE: Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS), and Bickerstaff brainstem encephalitis (BBE) are usually monophasic, but some patients experience recurrences after long asymptomatic intervals. We aimed to investigate clinical features of recurrent GBS, MFS, and BBE at a single hospital. METHODS: Records from 97 consecutive patients with GBS, MFS or BBE who were admitted to a tertiary hospital between 2001 and 2013 were reviewed. Clinical and laboratory features of patients with recurrent GBS, MFS, or BBE were investigated. RESULTS: Patients included 55 (32 males) with GBS, 34 (22 males) with MFS, and 8 (6 males) with BBE. Recurrent cases occurred in 2 (4%) of the 55 patients with GBS, 4 (12%) of the 34 patients with MFS, and 2 (25%) of the 8 patients with BBE. Patients with recurrent MFS had a tendency to be younger at the first episode than patients with non-recurrent MFS (median, 22 versus 37years old). Symptoms and signs were less severe during relapses than during the initial episode in recurrent patients. CONCLUSIONS: Recurrences occurred more frequently in patients with MFS or BBE compared with those with GBS. Patients with recurrent MFS might be younger than those with non-recurrent MFS.
OBJECTIVE: Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS), and Bickerstaff brainstem encephalitis (BBE) are usually monophasic, but some patients experience recurrences after long asymptomatic intervals. We aimed to investigate clinical features of recurrent GBS, MFS, and BBE at a single hospital. METHODS: Records from 97 consecutive patients with GBS, MFS or BBE who were admitted to a tertiary hospital between 2001 and 2013 were reviewed. Clinical and laboratory features of patients with recurrent GBS, MFS, or BBE were investigated. RESULTS:Patients included 55 (32 males) with GBS, 34 (22 males) with MFS, and 8 (6 males) with BBE. Recurrent cases occurred in 2 (4%) of the 55 patients with GBS, 4 (12%) of the 34 patients with MFS, and 2 (25%) of the 8 patients with BBE. Patients with recurrent MFS had a tendency to be younger at the first episode than patients with non-recurrent MFS (median, 22 versus 37years old). Symptoms and signs were less severe during relapses than during the initial episode in recurrent patients. CONCLUSIONS: Recurrences occurred more frequently in patients with MFS or BBE compared with those with GBS. Patients with recurrent MFS might be younger than those with non-recurrent MFS.
Authors: Lisette Bazán-Rodríguez; Juan Carlos López-Hernández; Adib Jorge de Saráchaga; Enrique Gómez-Figueroa; Elizabeth Leon-Manriquez; Maria Eugenia Briseño-Godinez; Raúl May-Mas; Esther Y Pérez-Valdez; Enrique Pérez-Jovel; Steven Vargas-Cañas Journal: Neurol Sci Date: 2021-02-16 Impact factor: 3.307