Literature DB >> 27083564

Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma.

Guoren Zhou1, Jinjun Ye2, Lei Sun3, Zhi Zhang1, Jifeng Feng4.   

Abstract

Dishevelled-2 (Dvl2) was associated with tumor cell proliferation and migration. We aimed to examine the mechanism of Dvl2 in esophageal squamous cell carcinoma (ESCC). Dvl2 was overexpressed in human ESCC tissues and cell lines ECA109 and TE1 cells. CCK-8 and colony formation assay was performed to evaluate the proliferation in ECA109 cells transfected with Dvl2-shRNA. Wound-healing assay and transwell assay were used to examine the activities of migration and invasion in Dvl2-silenced ESCC cells. Knockdown of Dvl2 significantly reduced ECA109 cell proliferation and migration. Moreover, we demonstrated that the proliferation and migration ability of Dvl2 might through the activation of Wnt pathway by targeting the Cyclin D1 and MMP-9. We came to the conclusion that the proliferation and migration effects of Dvl2 might contribute to malignant development of human ESCC.

Entities:  

Keywords:  Dvl2; Esophageal squamous cell carcinoma; Migration; Proliferation; Wnt signaling activation

Mesh：

Substances：

Year:  2016        PMID： 27083564     DOI： 10.1007/s10735-016-9674-3

Source DB:  PubMed          Journal:  J Mol Histol        ISSN： 1567-2379            Impact factor:   2.611


  32 in total

Review 1.  Dishevelled: The hub of Wnt signaling.

Authors:  Chan Gao; Ye-Guang Chen
Journal:  Cell Signal       Date:  2009-12-13       Impact factor: 4.315

Review 2.  Cancer treatment and survivorship statistics, 2012.

Authors:  Rebecca Siegel; Carol DeSantis; Katherine Virgo; Kevin Stein; Angela Mariotto; Tenbroeck Smith; Dexter Cooper; Ted Gansler; Catherine Lerro; Stacey Fedewa; Chunchieh Lin; Corinne Leach; Rachel Spillers Cannady; Hyunsoon Cho; Steve Scoppa; Mark Hachey; Rebecca Kirch; Ahmedin Jemal; Elizabeth Ward
Journal:  CA Cancer J Clin       Date:  2012-06-14       Impact factor: 508.702

3.  Dishevelled controls cell polarity during Xenopus gastrulation.

Authors:  J B Wallingford; B A Rowning; K M Vogeli; U Rothbächer; S E Fraser; R M Harland
Journal:  Nature       Date:  2000-05-04       Impact factor: 49.962

Review 4.  Wnt signaling and cancer development: therapeutic implication.

Authors:  S Paul; A Dey
Journal:  Neoplasma       Date:  2008       Impact factor: 2.575

5.  Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression.

Authors:  Kazutsugu Uematsu; Biao He; Liang You; Zhidong Xu; Frank McCormick; David Mark Jablons
Journal:  Oncogene       Date:  2003-10-16       Impact factor: 9.867

Review 6.  Role of matrix metalloproteinases (MMPs) in colorectal cancer.

Authors:  Stanley Zucker; Jeffrey Vacirca
Journal:  Cancer Metastasis Rev       Date:  2004 Jan-Jun       Impact factor: 9.264

7.  Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis.

Authors:  Chunping Yu; Kun Chen; Haiqing Zheng; Xianzhi Guo; Weihua Jia; Manzhi Li; Musheng Zeng; Jun Li; Libing Song
Journal:  Carcinogenesis       Date:  2009-03-20       Impact factor: 4.944

8.  Glycogen synthase kinase-3 beta is involved in the phosphorylation and suppression of androgen receptor activity.

Authors:  Thomas R Salas; Jeri Kim; Funda Vakar-Lopez; Anita L Sabichi; Patricia Troncoso; Guido Jenster; Akira Kikuchi; Shao-Yong Chen; Lirim Shemshedini; Milind Suraokar; Christopher J Logothetis; John DiGiovanni; Scott M Lippman; David G Menter
Journal:  J Biol Chem       Date:  2004-02-24       Impact factor: 5.157

9.  Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.

Authors:  M Tada; J C Smith
Journal:  Development       Date:  2000-05       Impact factor: 6.868

10.  cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

Authors:  A Pizzuti; F Amati; G Calabrese; A Mari; A Colosimo; V Silani; L Giardino; A Ratti; D Penso; L Calzà; G Palka; G Scarlato; G Novelli; B Dallapiccola
Journal:  Hum Mol Genet       Date:  1996-07       Impact factor: 6.150
View more
  5 in total

1.  Over-expression of IQGAP1 indicates poor prognosis in head and neck squamous cell carcinoma.

Authors:  Cong-Cong Wu; Hao Li; Yao Xiao; Lei-Lei Yang; Lei Chen; Wei-Wei Deng; Lei Wu; Wen-Feng Zhang; Zhi-Jun Sun
Journal:  J Mol Histol       Date:  2018-05-30       Impact factor: 2.611

2.  Dishevelled proteins and CYLD reciprocally regulate each other in CML cell lines.

Authors:  Ceyda Çalışkan; Melek Pehlivan; Zeynep Yüce; Ogun Sercan
Journal:  Mol Biol Rep       Date:  2017-08-24       Impact factor: 2.316

3.  Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse.

Authors:  Junji Inoue; Hirofumi Fujita; Tetsuya Bando; Yoichi Kondo; Hiromi Kumon; Hideyo Ohuchi
Journal:  J Mol Histol       Date:  2016-11-19       Impact factor: 2.611

4.  Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-κB pathway.

Authors:  Xing Zhen Liu; Jie Fan; Ke Qi; Shu Peng Liu; Wei Dong Xu; Ying Gao; Xiao Dan Gu; Jia Li; Chen Guang Bai; Ye Qing Shi; Lan Ling Zhang; Dong Bao Zhao
Journal:  Oncotarget       Date:  2017-02-21

5.  Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis.

Authors:  Lihua Zhang; Luan Luan; Yingying Ma
Journal:  Mol Med Rep       Date:  2018-05-04       Impact factor: 2.952
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.