Time-of-flight mass spectrometry: State-of the-art in chemical analysis and molecular science.

Time-of-flight instruments form a well-established group of mass spectrometers, with its popularity still increasing. This article gives a survey of the technical basics and important instrumental developments in this field. Special notice is taken of factors that limit the mass resolution and to techniques to overcome them. The possibilities to perform tandem MS experiments in flight-time mass analyzers and their combination with ion-trapping devices are discussed. Finally, some examples of the modern applications of these instruments in molecular science and instrumental analysis are reviewed. © 1997 John Wiley & Sons, Inc.