| Literature DB >> 2708157 |
Abstract
The effect on the electrophysiological hearing thresholds and the endocochlear DC potential (EP) was studied in four groups of guinea pigs receiving different doses of cisplatin. By multiple low-dose intraperitoneal injections a permanent hearing loss was produced without a permanent decrease of the EP. On the other hand, when cisplatin was given as a single high-dose intravenous injection, there was an impairment of the electrophysiological hearing thresholds and EP, depending upon the level of cisplatin dose. It is concluded that cisplatin-induced hearing loss is not necessarily a sequela to a loss of EP.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2708157 DOI： 10.1016/0378-5955(89)90125-1
Source DB: PubMed Journal: Hear Res ISSN： 0378-5955 Impact factor: 3.208