Literature DB >> 27081174

Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling.

Katharina Filarsky1, Angela Garding2, Natalia Becker3, Christine Wolf1, Manuela Zucknick4, Rainer Claus5, Dieter Weichenhan6, Christoph Plass6, Hartmut Döhner7, Stephan Stilgenbauer7, Peter Lichter8, Daniel Mertens9.   

Abstract

Entities:  

Keywords:  Krüppel-like factor 4; NOTCH signaling; chronic lymphocytic lymphoma; inactivation; inhibition; promoter DNA-methylation

Mesh：

Substances：

Year:  2016        PMID： 27081174      PMCID： PMC5013946          DOI： 10.3324/haematol.2015.138172

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  15 in total

1.  Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses.

Authors:  Kim L Good; Stuart G Tangye
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-02       Impact factor: 11.205

Review 2.  Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells.

Authors:  Rajendra N Damle; Carlo Calissano; Nicholas Chiorazzi
Journal:  Best Pract Res Clin Haematol       Date:  2010-03       Impact factor: 3.020

3.  Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

Authors:  Marta Kulis; Simon Heath; Marina Bibikova; Ana C Queirós; Alba Navarro; Guillem Clot; Alejandra Martínez-Trillos; Giancarlo Castellano; Isabelle Brun-Heath; Magda Pinyol; Sergio Barberán-Soler; Panagiotis Papasaikas; Pedro Jares; Sílvia Beà; Daniel Rico; Simone Ecker; Miriam Rubio; Romina Royo; Vincent Ho; Brandy Klotzle; Lluis Hernández; Laura Conde; Mónica López-Guerra; Dolors Colomer; Neus Villamor; Marta Aymerich; María Rozman; Mónica Bayes; Marta Gut; Josep L Gelpí; Modesto Orozco; Jian-Bing Fan; Víctor Quesada; Xose S Puente; David G Pisano; Alfonso Valencia; Armando López-Guillermo; Ivo Gut; Carlos López-Otín; Elías Campo; José I Martín-Subero
Journal:  Nat Genet       Date:  2012-10-14       Impact factor: 38.330

4.  Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.

Authors:  Xose S Puente; Magda Pinyol; Víctor Quesada; Laura Conde; Gonzalo R Ordóñez; Neus Villamor; Georgia Escaramis; Pedro Jares; Sílvia Beà; Marcos González-Díaz; Laia Bassaganyas; Tycho Baumann; Manel Juan; Mónica López-Guerra; Dolors Colomer; José M C Tubío; Cristina López; Alba Navarro; Cristian Tornador; Marta Aymerich; María Rozman; Jesús M Hernández; Diana A Puente; José M P Freije; Gloria Velasco; Ana Gutiérrez-Fernández; Dolors Costa; Anna Carrió; Sara Guijarro; Anna Enjuanes; Lluís Hernández; Jordi Yagüe; Pilar Nicolás; Carlos M Romeo-Casabona; Heinz Himmelbauer; Ester Castillo; Juliane C Dohm; Silvia de Sanjosé; Miguel A Piris; Enrique de Alava; Jesús San Miguel; Romina Royo; Josep L Gelpí; David Torrents; Modesto Orozco; David G Pisano; Alfonso Valencia; Roderic Guigó; Mónica Bayés; Simon Heath; Marta Gut; Peter Klatt; John Marshall; Keiran Raine; Lucy A Stebbings; P Andrew Futreal; Michael R Stratton; Peter J Campbell; Ivo Gut; Armando López-Guillermo; Xavier Estivill; Emili Montserrat; Carlos López-Otín; Elías Campo
Journal:  Nature       Date:  2011-06-05       Impact factor: 49.962

5.  Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry.

Authors:  Mathias Ehrich; Matthew R Nelson; Patrick Stanssens; Marc Zabeau; Triantafillos Liloglou; George Xinarianos; Charles R Cantor; John K Field; Dirk van den Boom
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-21       Impact factor: 11.205

6.  KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma.

Authors:  Hanfeng Guan; Linka Xie; Frank Leithäuser; Lucia Flossbach; Peter Möller; Thomas Wirth; Alexey Ushmorov
Journal:  Blood       Date:  2010-06-02       Impact factor: 22.113

7.  The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia.

Authors:  Yair Herishanu; Patricia Pérez-Galán; Delong Liu; Angélique Biancotto; Stefania Pittaluga; Berengere Vire; Federica Gibellini; Ndegwa Njuguna; Elinor Lee; Lawrence Stennett; Nalini Raghavachari; Poching Liu; J Philip McCoy; Mark Raffeld; Maryalice Stetler-Stevenson; Constance Yuan; Richard Sherry; Diane C Arthur; Irina Maric; Therese White; Gerald E Marti; Peter Munson; Wyndham H Wilson; Adrian Wiestner
Journal:  Blood       Date:  2010-10-12       Impact factor: 22.113

8.  Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferation.

Authors:  Jettanong Klaewsongkram; Yinhua Yang; Susanne Golech; Jonathan Katz; Klaus H Kaestner; Nan-Ping Weng
Journal:  J Immunol       Date:  2007-10-01       Impact factor: 5.422

9.  Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

Authors:  Angela Garding; Nupur Bhattacharya; Rainer Claus; Melanie Ruppel; Cordula Tschuch; Katharina Filarsky; Irina Idler; Manuela Zucknick; Maïwen Caudron-Herger; Christopher Oakes; Verena Fleig; Ioanna Keklikoglou; Danilo Allegra; Leticia Serra; Sudhir Thakurela; Vijay Tiwari; Dieter Weichenhan; Axel Benner; Bernhard Radlwimmer; Hanswalter Zentgraf; Stefan Wiemann; Karsten Rippe; Christoph Plass; Hartmut Döhner; Peter Lichter; Stephan Stilgenbauer; Daniel Mertens
Journal:  PLoS Genet       Date:  2013-04-04       Impact factor: 5.917

10.  Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.

Authors:  Pedro J Real; Valeria Tosello; Teresa Palomero; Mireia Castillo; Eva Hernando; Elisa de Stanchina; Maria Luisa Sulis; Kelly Barnes; Catherine Sawai; Irene Homminga; Jules Meijerink; Iannis Aifantis; Giuseppe Basso; Carlos Cordon-Cardo; Walden Ai; Adolfo Ferrando
Journal:  Nat Med       Date:  2008-12-21       Impact factor: 53.440
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  14 in total

Review 1.  Novel tumor-suppressor function of KLF4 in pediatric T-cell acute lymphoblastic leukemia.

Authors:  Ye Shen; Taylor J Chen; H Daniel Lacorazza
Journal:  Exp Hematol       Date:  2017-05-04       Impact factor: 3.084

2.  Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion.

Authors:  Yan Xiu; Qianze Dong; Lin Fu; Aaron Bossler; Xiaobing Tang; Brendan Boyce; Nicholas Borcherding; Mariah Leidinger; José Luis Sardina; Hai-Hui Xue; Qingchang Li; Andrew Feldman; Iannis Aifantis; Francesco Boccalatte; Lili Wang; Meiling Jin; Joseph Khoury; Wei Wang; Shimin Hu; Youzhong Yuan; Endi Wang; Ji Yuan; Siegfried Janz; John Colgan; Hasem Habelhah; Thomas Waldschmidt; Markus Müschen; Adam Bagg; Benjamin Darbro; Chen Zhao
Journal:  Blood       Date:  2020-01-09       Impact factor: 22.113

3.  Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia.

Authors:  Andrew Henry Lewis; Cory Seth Bridges; David Neal Moorshead; Taylor J Chen; Wa Du; Barry Zorman; Pavel Sumazin; Monica Puppi; H Daniel Lacorazza
Journal:  Stem Cells       Date:  2022-08-25       Impact factor: 5.845

4.  Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway.

Authors:  Y Shen; C S Park; K Suppipat; T-A Mistretta; M Puppi; T M Horton; K Rabin; N S Gray; J P P Meijerink; H D Lacorazza
Journal:  Leukemia       Date:  2016-11-22       Impact factor: 12.883

5.  CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer in vitro and in vivo.

Authors:  Xin Xu; Jiangfeng Li; Yi Zhu; Bo Xie; Xiao Wang; Song Wang; Haiyun Xie; Huaqing Yan; Yufan Ying; Yiwei Lin; Ben Liu; Wei Wang; Xiangyi Zheng
Journal:  Oncotarget       Date:  2017-10-27

Review 6.  Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis.

Authors:  Nazanin Heidari; Saeid Abroun; Jessika Bertacchini; Tina Vosoughi; Fakher Rahim; Najmaldin Saki
Journal:  Cell J       Date:  2017-05-17       Impact factor: 2.479

7.  Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL.

Authors:  Wen-Hsin Liu; Paulina Mrozek-Gorska; Anna-Katharina Wirth; Tobias Herold; Larissa Schwarzkopf; Dagmar Pich; Kerstin Völse; M Camila Melo-Narváez; Michela Carlet; Wolfgang Hammerschmidt; Irmela Jeremias
Journal:  Biomark Res       Date:  2020-09-16

Review 8.  Molecular Interactions Between Innate and Adaptive Immune Cells in Chronic Lymphocytic Leukemia and Their Therapeutic Implications.

Authors:  Muhammad Haseeb; Muhammad Ayaz Anwar; Sangdun Choi
Journal:  Front Immunol       Date:  2018-11-26       Impact factor: 7.561

9.  RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of P57.

Authors:  Shuang Liu; Yanyan Xing; Wenting Lu; Shouyun Li; Zheng Tian; Haiyan Xing; Kejing Tang; Yingxi Xu; Qing Rao; Min Wang; Jianxiang Wang
Journal:  Haematologica       Date:  2019-02-21       Impact factor: 9.941

Review 10.  From Biology to Therapy: The CLL Success Story.

Authors:  Deyan Y Yosifov; Christine Wolf; Stephan Stilgenbauer; Daniel Mertens
Journal:  Hemasphere       Date:  2019-02-09
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