Literature DB >> 27080952

Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans.

Angie D Calderon1, Yunpeng Liu2, Xu Li1, Xuan Wang1, Xi Chen3, Lei Li1, Peng G Wang1.   

Abstract

Substrate specificity studies of human FUT8 using 77 structurally-defined N-glycans as acceptors showed a strict requirement towards the α1,3-mannose branch, but a great promiscuity towards the α1,6-mannose branch. Accordingly, a chemoenzymatic strategy was developed for the efficient synthesis of core-fucosylated asymmetric N-glycans.

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Year:  2016        PMID： 27080952      PMCID： PMC4852481          DOI： 10.1039/c6ob00586a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  36 in total

1.  Remarkable transglycosylation activity of glycosynthase mutants of endo-D, an endo-β-N-acetylglucosaminidase from Streptococcus pneumoniae.

Authors:  Shu-Quan Fan; Wei Huang; Lai-Xi Wang
Journal:  J Biol Chem       Date:  2012-02-08       Impact factor: 5.157

2.  The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus.

Authors:  David J Wasilko; S Edward Lee; Kim J Stutzman-Engwall; Beverly A Reitz; Thomas L Emmons; Karl J Mathis; Michael J Bienkowski; Alfredo G Tomasselli; H David Fischer
Journal:  Protein Expr Purif       Date:  2009-01-11       Impact factor: 1.650

3.  Fucosyltransferases as synthetic tools: glycan array based substrate selection and core fucosylation of synthetic N-glycans.

Authors:  Sonia Serna; Shi Yan; Manuel Martin-Lomas; Iain B H Wilson; Niels-Christian Reichardt
Journal:  J Am Chem Soc       Date:  2011-09-22       Impact factor: 15.419

4.  Fucosyltransferase substrate specificity and the order of fucosylation in invertebrates.

Authors:  Katharina Paschinger; Erika Staudacher; Ute Stemmer; Gustáv Fabini; Iain B H Wilson
Journal:  Glycobiology       Date:  2004-12-15       Impact factor: 4.313

5.  Characterization of the oligosaccharide structures associated with the cystic fibrosis transmembrane conductance regulator.

Authors:  C R O'Riordan; A L Lachapelle; J Marshall; E A Higgins; S H Cheng
Journal:  Glycobiology       Date:  2000-11       Impact factor: 4.313

6.  The fucosylation index of alpha-fetoprotein as a possible prognostic indicator for patients with hepatocellular carcinoma.

Authors:  Y Aoyagi; O Isokawa; T Suda; M Watanabe; Y Suzuki; H Asakura
Journal:  Cancer       Date:  1998-11-15       Impact factor: 6.860

7.  Pre-activation-based one-pot synthesis of an alpha-(2,3)-sialylated core-fucosylated complex type bi-antennary N-glycan dodecasaccharide.

Authors:  Bin Sun; Balasubramanian Srinivasan; Xuefei Huang
Journal:  Chemistry       Date:  2008       Impact factor: 5.236

Review 8.  Functional roles of N-glycans in cell signaling and cell adhesion in cancer.

Authors:  Yan-Yang Zhao; Motoko Takahashi; Jian-Guo Gu; Eiji Miyoshi; Akio Matsumoto; Shinobu Kitazume; Naoyuki Taniguchi
Journal:  Cancer Sci       Date:  2008-05-19       Impact factor: 6.716

Review 9.  Roles of N-linked glycans in the endoplasmic reticulum.

Authors:  Ari Helenius; Markus Aebi
Journal:  Annu Rev Biochem       Date:  2004       Impact factor: 23.643

10.  Efficient Chemoenzymatic Synthesis of an N-glycan Isomer Library.

Authors:  Lei Li; Yunpeng Liu; Cheng Ma; Jingyao Qu; Angie D Calderon; Baolin Wu; Na Wei; Xuan Wang; Yuxi Guo; Zhongying Xiao; Jing Song; Go Sugiarto; Yanhong Li; Hai Yu; Xi Chen; Peng George Wang
Journal:  Chem Sci       Date:  2015-06-23       Impact factor: 9.825
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  19 in total

1.  Microarray analyses of closely related glycoforms reveal different accessibilities of glycan determinants on N-glycan branches.

Authors:  Lei Li; Wanyi Guan; Gaolan Zhang; Zhigang Wu; Hai Yu; Xi Chen; Peng G Wang
Journal:  Glycobiology       Date:  2020-04-20       Impact factor: 4.313

2.  An enzymatic strategy to asymmetrically branched N-glycans.

Authors:  Angie D Calderon; Jun Zhou; Wanyi Guan; Zhigang Wu; Yuxi Guo; Jing Bai; Qing Li; Peng George Wang; Junqiang Fang; Lei Li
Journal:  Org Biomol Chem       Date:  2017-09-13       Impact factor: 3.876

3.  Revisiting the substrate specificity of mammalian α1,6-fucosyltransferase reveals that it catalyzes core fucosylation of N-glycans lacking α1,3-arm GlcNAc.

Authors:  Qiang Yang; Roushu Zhang; Hui Cai; Lai-Xi Wang
Journal:  J Biol Chem       Date:  2017-07-20       Impact factor: 5.157

4.  Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes.

Authors:  Zhigang Wu; Yunpeng Liu; Cheng Ma; Lei Li; Jing Bai; Lauren Byrd-Leotis; Yi Lasanajak; Yuxi Guo; Liuqing Wen; He Zhu; Jing Song; Yanhong Li; David A Steinhauer; David F Smith; Baohua Zhao; Xi Chen; Wanyi Guan; Peng George Wang
Journal:  Org Biomol Chem       Date:  2016-11-29       Impact factor: 3.876

5.  Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.

Authors:  Bhargavi M Boruah; Renuka Kadirvelraj; Lin Liu; Annapoorani Ramiah; Chao Li; Guanghui Zong; Gerlof P Bosman; Jeong-Yeh Yang; Lai-Xi Wang; Geert-Jan Boons; Zachary A Wood; Kelley W Moremen
Journal:  J Biol Chem       Date:  2020-10-01       Impact factor: 5.157

6.  Structural basis of substrate recognition and catalysis by fucosyltransferase 8.

Authors:  Michael A Järvå; Marija Dramicanin; James P Lingford; Runyu Mao; Alan John; Kate E Jarman; Rhys Grinter; Ethan D Goddard-Borger
Journal:  J Biol Chem       Date:  2020-03-27       Impact factor: 5.157

7.  Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins.

Authors:  Chao Li; Shilei Zhu; Christopher Ma; Lai-Xi Wang
Journal:  J Am Chem Soc       Date:  2017-10-16       Impact factor: 15.419

8.  Appropriate aglycone modification significantly expands the glycan substrate acceptability of α1,6-fucosyltransferase (FUT8).

Authors:  Roushu Zhang; Qiang Yang; Bhargavi M Boruah; Guanghui Zong; Chao Li; Digantkumar Chapla; Jeong-Yeh Yang; Kelley W Moremen; Lai-Xi Wang
Journal:  Biochem J       Date:  2021-04-30       Impact factor: 3.857

Review 9.  FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment.

Authors:  Chengcheng Liao; Jiaxing An; Suqin Yi; Zhangxue Tan; Hui Wang; Hao Li; Xiaoyan Guan; Jianguo Liu; Qian Wang
Journal:  J Cancer       Date:  2021-05-13       Impact factor: 4.207

10.  Comparative studies on the substrate specificity and defucosylation activity of three α-l-fucosidases using synthetic fucosylated glycopeptides and glycoproteins as substrates.

Authors:  Sunaina Kiran Prabhu; Chao Li; Guanghui Zong; Roushu Zhang; Lai-Xi Wang
Journal:  Bioorg Med Chem       Date:  2021-06-07       Impact factor: 3.461
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