| Literature DB >> 27080435 |
Marta Meazza1, Maria Ashe1, Hun Yi Shin2, Hye Sung Yang2, Andrea Mazzanti3, Jung Woon Yang2, Ramon Rios1.
Abstract
Herein, we describe the first enantioselective cyclopropanation of enals using benzyl chlorides as bifunctional (nucleophilic and electrophilic) reagents. The reaction is simply catalyzed by chiral secondary amines to afford the formyl cyclopropane derivatives in good yields with moderate to excellent stereoselectivities.Entities:
Year: 2016 PMID： 27080435 DOI： 10.1021/acs.joc.5b02801
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354