Indu Varier1, Brieze R Keeley2, Rosemarie Krupar1, Alexis Patsias2,3, Joanna Dong2, Nikita Gupta2, Arjun K Parasher2, Eric M Genden2, Brett A Miles2, Marita Teng2, Richard L Bakst4, Vishal Gupta4, Krzysztof J Misiukiewicz5, Elizabeth Y Chiao6,7, Michael E Scheurer8, Simon Laban9, David Zhang10, Fei Ye10, Miao Cui10, Elizabeth G Demicco10, Marshall R Posner5, Andrew G Sikora1. 1. Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA. 2. Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine, NY, USA. 3. Department of Otolaryngology - Head and Neck Surgery, University Oklahoma Health Sciences Center, OK, USA. 4. Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, NY, USA. 5. Department of Medical Oncology, Icahn School of Medicine at Mount Sinai, NY, USA. 6. Department of Internal Medicine and Health Services Research, Baylor College of Medicine, Houston, TX, USA. 7. Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center, Houston, TX, USA. 8. Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA. 9. Head and Neck Cancer Center Ulm, Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Medical Center Ulm, Ulm, Baden-Württemberg, Germany. 10. Department of Pathology, Icahn school of Medicine at Mount Sinai, NY, USA.
Abstract
BACKGROUND: The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes. METHODS: This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high-risk non-HPV16 groups. RESULTS: High-risk non-HPV16 genotypes accounted for 9% of HPV-related OPC. Of the 27 total high-risk non-HPV16 OPCs, HPV35 was most prevalent (48%). High-risk non-HPV16 OPC presented at a slightly higher age (p = .021) and higher clinical T classification (p = .008) compared to HPV16 OPC, but there was no significant survival difference. CONCLUSION: Clinical characteristics of high-risk non-HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi-institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high-risk HPV types.
BACKGROUND: The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes. METHODS: This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high-risk non-HPV16 groups. RESULTS: High-risk non-HPV16 genotypes accounted for 9% of HPV-related OPC. Of the 27 total high-risk non-HPV16 OPCs, HPV35 was most prevalent (48%). High-risk non-HPV16 OPC presented at a slightly higher age (p = .021) and higher clinical T classification (p = .008) compared to HPV16 OPC, but there was no significant survival difference. CONCLUSION: Clinical characteristics of high-risk non-HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi-institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high-risk HPV types.
Authors: Angela L Mazul; Nidia Rodriguez-Ormaza; James M Taylor; Dipan D Desai; Paul Brennan; Devasena Anantharaman; Tarik Gheit; Massimo Tommasino; Behnoush Abedi-Ardekani; Andrew F Olshan; Jose P Zevallos Journal: Oral Oncol Date: 2016-09-06 Impact factor: 5.337
Authors: Carole Fakhry; Tim Waterboer; William H Westra; Lisa M Rooper; Melina Windon; Tanya Troy; Wayne Koch; Christine G Gourin; Noemi Bender; Siddhartha Yavvari; Ana P Kiess; Brett A Miles; William R Ryan; Patrick K Ha; David W Eisele; Gypsyamber D'Souza Journal: Oral Oncol Date: 2019-12-24 Impact factor: 5.337
Authors: Linda X Yin; Gypsyamber D'Souza; William H Westra; Steven J Wang; Annemieke van Zante; Yuehan Zhang; Eleni M Rettig; William R Ryan; Patrick K Ha; Alicia Wentz; Wayne Koch; David W Eisele; Carole Fakhry Journal: Laryngoscope Date: 2018-03-14 Impact factor: 3.325
Authors: Rachel F Shenker; Nelson H May; Joshua D Waltonen; Jae Paul Yang; Stacey S O'Neill; Bart A Frizzell; Kathryn M Greven; Ryan T Hughes Journal: Head Neck Pathol Date: 2021-02-22