Andrew J Rosko1, Matthew E Spector1, Garrett R Griffin1,2, Jeffrey M Vainshtein3,4, Jae Lee3, Carol R Bradford1, Mark E P Prince1, Jeffrey S Moyer1, Francis P Worden5, Avraham Eisbruch3, Douglas B Chepeha1,6. 1. Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan. 2. Midwest ENT Specialists, Woodbury, Minnesota. 3. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. 4. Department of Radiation Oncology, Emory University, Atlanta, Georgia. 5. Department of Medical Oncology, University of Michigan, Ann Arbor, Michigan. 6. Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
Abstract
BACKGROUND: Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection. METHODS: We conducted a retrospective case series of 6 patients presenting from 2003 to 2012 with a history of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) followed by salvage laryngectomy. RESULTS: Posterior neck and upper back pain developed a mean of 27.5 days after instrumentation of the pharynx (reconstruction after laryngectomy or pharyngeal dilation). Myelopathy developed an average of 21.5 days after the onset of posterior neck pain. Five patients required urgent decompression. Three patients developed quadriplegia. The disease-specific mortality was 50%. CONCLUSION: There is a syndrome of late neurological effects after RT, salvage surgery, and pharyngeal instrumentation that is associated with high morbidity and mortality.
BACKGROUND: Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection. METHODS: We conducted a retrospective case series of 6 patients presenting from 2003 to 2012 with a history of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) followed by salvage laryngectomy. RESULTS: Posterior neck and upper back pain developed a mean of 27.5 days after instrumentation of the pharynx (reconstruction after laryngectomy or pharyngeal dilation). Myelopathy developed an average of 21.5 days after the onset of posterior neck pain. Five patients required urgent decompression. Three patients developed quadriplegia. The disease-specific mortality was 50%. CONCLUSION: There is a syndrome of late neurological effects after RT, salvage surgery, and pharyngeal instrumentation that is associated with high morbidity and mortality.
Authors: Dale C Ekbom; Joanna D-Elia; Brandon Isaacson; Frank Lamarca; Douglas B Chepeha; Carol R Bradford Journal: Head Neck Date: 2005-06 Impact factor: 3.147
Authors: Ann D King; James F Griffith; Jill M Abrigo; Sing-Fai Leung; Fung-kwai Yau; Gary M K Tse; Anil T Ahuja Journal: Eur J Radiol Date: 2009-02-05 Impact factor: 3.528