Xin Xu1,2, Saima Hilal1,2, Simon L Collinson3, Qun Lin Chan1,2, Eddie Jun Yi Chong1,2, Mohammad Kamran Ikram2,4, Narayanaswamy Venketasubramanian2,5, Ching-Yu Cheng4,6, Tien Yin Wong4,6, Christopher Li-Hsian Chen1,2. 1. Department of Pharmacology, National University of Singapore, Singapore. 2. Memory Aging and Cognition Centre, National University Health System, Singapore. 3. Department of Psychology, National University of Singapore, Singapore. 4. Academic Medicine Research Institute, Duke-NUS Graduate Medical School National University of Singapore, Singapore. 5. Raffles Neuroscience Centre, Raffles Hospital, Singapore. 6. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Abstract
BACKGROUND: A total cerebrovascular disease (CeVD) burden scale was previously constructed and an inverse association of CeVD burden and cognition was found. However, the generalizability of the CeVD scale has not been examined. OBJECTIVE: The objective was to validate the previously constructed total CeVD burden scale by establishing its association with cognitive function and dementia diagnosis in a community sample. METHODS: Eligible participants were assessed on an extensive neuropsychological battery and underwent MRI scans. The total CeVD scale, comprising markers of both small- and large-vessel diseases, was derived according to previously described criteria. Association of total CeVD burden with global and domain-based cognitive performance and dementia diagnostic utility of the scale was established. RESULTS: A total of 863 participants were included in the analysis. A stepwise association of CeVD burden score with global and domain-specific cognitive function was found. Per score increase on the total CeVD burden scale was associated with 3.6 (95% CI = 2.1-6.4) times higher odds of dementia compared to dementia-free. DISCUSSION: The total CeVD burden scale is associated with cognition and dementia in a community sample. Longitudinal studies are required to establish the predictive ability of this scale.
BACKGROUND: A total cerebrovascular disease (CeVD) burden scale was previously constructed and an inverse association of CeVD burden and cognition was found. However, the generalizability of the CeVD scale has not been examined. OBJECTIVE: The objective was to validate the previously constructed total CeVD burden scale by establishing its association with cognitive function and dementia diagnosis in a community sample. METHODS: Eligible participants were assessed on an extensive neuropsychological battery and underwent MRI scans. The total CeVD scale, comprising markers of both small- and large-vessel diseases, was derived according to previously described criteria. Association of total CeVD burden with global and domain-based cognitive performance and dementia diagnostic utility of the scale was established. RESULTS: A total of 863 participants were included in the analysis. A stepwise association of CeVD burden score with global and domain-specific cognitive function was found. Per score increase on the total CeVD burden scale was associated with 3.6 (95% CI = 2.1-6.4) times higher odds of dementia compared to dementia-free. DISCUSSION: The total CeVD burden scale is associated with cognition and dementia in a community sample. Longitudinal studies are required to establish the predictive ability of this scale.
Authors: Xin Xu; April Phua; Simon L Collinson; Saima Hilal; Mohammad Kamran Ikram; Tien Yin Wong; Ching Yu Cheng; Narayanaswamy Venketasubramanian; Christopher Chen Journal: Stroke Vasc Neurol Date: 2019-06-20