Literature DB >> 27079543

Exploiting plug-and-play electrochemistry for drug discovery.

Lixia Gao1, Yong Teng2,3.   

Abstract

Electrochemistry has emerged as a powerful analytical technique for chemical analysis of living cells, biologically active molecules and metabolites. Electrochemical biosensor, microfluidics and mass spectrometry are the most frequently used methods for electrochemical detection and monitory, which comprise a collection of extremely useful measurement tools for various fields of biology and medicine. Most recently, electrochemistry has been shown to be coupled with nanotechnology and genetic engineering to generate new enabling technologies, providing rapid, selective, and sensitive detection and diagnosis platforms. The primary focus of this review is to highlight the utility of electrochemical strategies and their conjunction with other approaches for drug metabolism and discovery. Current challenges and possible future developments and applications of electrochemistry in drug studies are also discussed.

Keywords:  drug discovery; drug metabolism; electrochemical biosensor; electrochemical mass spectrometry; electrochemical microfluidics; electrochemistry

Mesh:

Substances:

Year:  2016        PMID: 27079543     DOI: 10.4155/fmc.16.8

Source DB:  PubMed          Journal:  Future Med Chem        ISSN: 1756-8919            Impact factor:   3.808


  4 in total

1.  Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis.

Authors:  Lixia Gao; Xiangdong Zhao; Liwei Lang; Chloe Shay; W Andrew Yeudall; Yong Teng
Journal:  J Mol Med (Berl)       Date:  2018-07-18       Impact factor: 4.599

Review 2.  Current status and future prospects for enabling chemistry technology in the drug discovery process.

Authors:  Stevan W Djuric; Charles W Hutchins; Nari N Talaty
Journal:  F1000Res       Date:  2016-09-30

3.  FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib.

Authors:  Lixia Gao; Xuli Wang; Yaoliang Tang; Shuang Huang; Chien-An Andy Hu; Yong Teng
Journal:  J Exp Clin Cancer Res       Date:  2017-01-09

Review 4.  A Review of Optical Imaging Technologies for Microfluidics.

Authors:  Pan Zhou; Haipeng He; Hanbin Ma; Shurong Wang; Siyi Hu
Journal:  Micromachines (Basel)       Date:  2022-02-08       Impact factor: 2.891

  4 in total

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