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Literature DB >> 27079428

Deuterium medicinal chemistry comes of age.

Roger D Tung¹.

Abstract

Entities: Chemical

Keywords: drug design; drug development; pharmacodynamics; pharmacokinetics

Mesh：

Substances：
Deuterium

Year: 2016 PMID： 27079428 DOI： 10.4155/fmc-2016-0032

Source DB: PubMed Journal: Future Med Chem ISSN： 1756-8919 Impact factor: 3.808

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Cited

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13 in total

1. Stereoretentive Deuteration of α-Chiral Amines with D₂O.

Authors: Lillian V A Hale; Nathaniel K Szymczak
Journal: J Am Chem Soc Date: 2016-10-06 Impact factor: 15.419

2. Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.

Authors: Andreea L Turcu; Júlia Companys-Alemany; Matthew B Phillips; Dhilon S Patel; Christian Griñán-Ferré; M Isabel Loza; José M Brea; Belén Pérez; David Soto; Francesc X Sureda; Maria G Kurnikova; Jon W Johnson; Mercè Pallàs; Santiago Vázquez
Journal: Eur J Med Chem Date: 2022-04-08 Impact factor: 7.088

3. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

Authors: Laura Friggeri; Tatiana Y Hargrove; Girish Rachakonda; Anna L Blobaum; Paxtyn Fisher; Gabriel Melo de Oliveira; Cristiane França da Silva; Maria de Nazaré C Soeiro; W David Nes; Craig W Lindsley; Fernando Villalta; F Peter Guengerich; Galina I Lepesheva
Journal: J Med Chem Date: 2018-11-30 Impact factor: 7.446

4. Phase I clinical trial of HC-1119 soft capsule in Chinese healthy adult male subjects: Pharmacokinetics and safety of single-dose proportionality and effects of food.

Authors: Haiping Ma; Weidong Xu; Jin Ni; Naping Zhao; Shouyan Tang; Song Li; Tingting Cai; Jianping Xiu; Xin Kang; Shen Gao; Li Zhang; Tie Zhou
Journal: Prostate Date: 2021-11-22 Impact factor: 4.012

Deuterium medicinal chemistry comes of age.

1. Stereoretentive Deuteration of α-Chiral Amines with D₂O.

2. Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.

3. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

4. Phase I clinical trial of HC-1119 soft capsule in Chinese healthy adult male subjects: Pharmacokinetics and safety of single-dose proportionality and effects of food.

5. NHC-Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines.

6. Relevance of Hydrogen Bonds for the Histamine H2 Receptor-Ligand Interactions: A Lesson from Deuteration.

7. A New Highly Deuterated [¹⁸F]AV-45, [¹⁸F]D15FSP, for Imaging β-Amyloid Plaques in the Brain.

8. Enantioselective semireduction of allenes.

9. Highly Selective Directed Iridium-Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides.

10. Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative.