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Literature DB >> 27079372

The role of adiponectin in obesity-associated female-specific carcinogenesis.

Ganji Purnachandra Nagaraju¹, Balney Rajitha², Sheik Aliya³, Rama P Kotipatruni⁴, Appiya Santharam Madanraj⁵, Anthea Hammond⁶, Dongkyoo Park⁷, Srinivasulu Chigurupati⁸, Afroz Alam⁹, Subasini Pattnaik¹⁰.

Abstract

Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.

Entities: Disease Gene Species

Keywords: Adiponectin; Breast cancer; Cervical cancer; Endometrial cancer; Obesity; Ovarian cancer

Mesh：

Substances：

Year: 2016 PMID： 27079372 DOI： 10.1016/j.cytogfr.2016.03.014

Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638

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The role of adiponectin in obesity-associated female-specific carcinogenesis.

Review 1. Regulation of aromatase in cancer.

Review 2. Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.

Review 3. Contribution of immunomodulators to gastroesophageal reflux disease and its complications: stromal cells, interleukin 4, and adiponectin.

Review 4. Emerging role of adipokines in systemic lupus erythematosus.

5. Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers.

Review 6. A Functional Interplay between IGF-1 and Adiponectin.

7. Expression of Adiponectin Receptor-1 and Prognosis of Epithelial Ovarian Cancer Patients.

8. Adverse effect of excess body weight on survival in cervical cancer patients after surgery and radiotherapy.

Review 9. Serum adiponectin in breast cancer: A meta-analysis.

10. Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet.