Literature DB >> 27079247

Is 2% chlorhexidine gluconate in 70% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)?

Margaret McCann1, Fidelma Fitzpatrick2, George Mellotte3, Michael Clarke4.   

Abstract

A pilot randomized trial in 3 Irish outpatient hemodialysis units compared 2% chlorhexidine gluconate (CHG) in 70% isopropyl alcohol with routinely used CHG solutions for central venous catheter exit site antisepsis. We found no significant difference between the groups for the prevention of catheter-related bloodstream infections (1/53 vs 2/52; relative risk [RR], 0.49; 95% confidence interval [CI], 0.05-5.25; P = .55) and catheter-associated bloodstream infections (1/53 vs 4/52; RR, 0.25; 95% CI, 0.03-2.12; P = .16).
Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Hemodialysis; central venous catheters; chlorhexidine gluconate; clinical trial; infection prevention; skin cleansing

Mesh：

Substances：

Year:  2016        PMID： 27079247     DOI： 10.1016/j.ajic.2016.02.019

Source DB:  PubMed          Journal:  Am J Infect Control        ISSN： 0196-6553            Impact factor:   2.918


  5 in total

1.  What's new in skin antisepsis for short-term intravascular catheters: new data to address old problems?

Authors:  Olivier Mimoz; Vineet Chopra; Andreas Widmer
Journal:  Intensive Care Med       Date:  2016-08-11       Impact factor: 17.440

2.  Comparison of alcoholic chlorhexidine and povidone-iodine cutaneous antiseptics for the prevention of central venous catheter-related infection: a cohort and quasi-experimental multicenter study.

Authors:  Justine Pages; Pascal Hazera; Bruno Mégarbane; Damien du Cheyron; Marie Thuong; Jean-Jacques Dutheil; Xavier Valette; François Fournel; Leonard A Mermel; Jean-Paul Mira; Cédric Daubin; Jean-Jacques Parienti
Journal:  Intensive Care Med       Date:  2016-06-16       Impact factor: 17.440

Review 3.  Skin antisepsis for reducing central venous catheter-related infections.

Authors:  Nai Ming Lai; Nai An Lai; Elizabeth O'Riordan; Nathorn Chaiyakunapruk; Jacqueline E Taylor; Kenneth Tan
Journal:  Cochrane Database Syst Rev       Date:  2016-07-13

4.  Cluster-randomized crossover trial of chlorhexidine-alcohol versus iodine-alcohol for prevention of surgical-site infection (SKINFECT trial).

Authors:  A Charehbili; M B G Koek; J C A de Mol van Otterloo; M W G A Bronkhorst; P van der Zwaal; B Thomassen; E J Waasdorp; J A Govaert; A Bosman; J van den Bremer; A J Ploeg; H Putter; A P Meijs; C J H van de Velde; W van Gijn; R J Swijnenburg
Journal:  BJS Open       Date:  2019-05-20

5.  The implementation of a standardized optimal procedure for peripheral venous catheters' management: Results from a multi-dimensional assessment.

Authors:  Fabrizio Schettini; Lucrezia Ferrario; Emanuela Foglia; Elisabetta Garagiola; Lionello Parodi; Paolo Cavagnaro; Luca Garra; Antonella Valeri; Monica Cirone; Roberta Rapetti
Journal:  PLoS One       Date:  2022-01-27       Impact factor: 3.240
  5 in total

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