Dong-Jin Park1, Seong-Ho Kim2, Seong-Su Nah3, Ji Hyun Lee4, Seong-Kyu Kim5, Yeon-Ah Lee6, Seung-Jae Hong6, Hyun-Sook Kim7, Hye-Soon Lee8, Hyoun Ah Kim9, Chung-Il Joung10, Sang-Hyon Kim11, Shin-Seok Lee12. 1. Department of Rheumatology, Chonnam National University Hospital & Medical School, Gwangju. 2. Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan. 3. Department of Internal Medicine, Soonchunhyang University, College of Medicine, Cheonan. 4. Department of Internal Medicine, Maryknoll Medical Center, Busan. 5. Department of Internal Medicine, Catholic University of Daegu, School of Medicine, Daegu. 6. Department of Internal Medicine, School of Medicine, Kyung Hee University. 7. Department of Internal Medicine, Soonchunhyang University Seoul Hospital. 8. Department of Internal Medicine, Hanyang University College of Medicine and the Hospital for Rheumatic Diseases, Seoul. 9. Department of Allergy and Rheumatology, Ajou University Hospital, Ajou University School of Medicine, Suwon. 10. Department of Internal Medicine, Konyang University Medical School, Daejeon. 11. Department of Internal Medicine, School of Medicine, Keimyung University, Daegu, Korea. 12. Department of Rheumatology, Chonnam National University Hospital & Medical School, Gwangju shinseok@chonnam.ac.kr.
Abstract
OBJECTIVE: Researchers continue to gather evidence that transient receptor potential vanilloid (TRPV) channels contribute towards pain signalling pathways. However, it is unknown whether polymorphisms of the TRPV gene are associated with FM. For the first time, we investigated the association between the polymorphisms of the TRPV2 and TRPV3 genes, FM susceptibility and the severity of the symptoms. METHODS: A total of 409 patients with FM and 423 controls were enrolled from 10 medical centres that participated in the Korean nationwide FM survey. The alleles and genotypes at three positions [rs3813768(C > G), rs8121(C > T) and rs1129235(C > A)] in the TRPV2 gene and two positions [rs7216486 (G > A) and rs395357(C > T)] in the TRPV3 gene were genotyped. RESULTS: The frequencies of the alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with FM susceptibility. However, the GTA haplotype of TRPV2 showed a defence against FM susceptibility (P = 0.035). In addition, polymorphisms of TRPV3 were associated with symptom severity in FM patients. The single nucleotide polymorphism rs395357 of TRPV3 was associated with the scores of the Brief Fatigue Inventory (P = 0.017) in FM patients. Furthermore, haplotypes of TRPV3 were associated with the Brief Fatigue Inventory and the 36-item Short-Form Health Survey mental health summary scores (P = 0.036). CONCLUSION: This study was the first to evaluate the associations of TRPV gene polymorphisms with FM. Our results suggest that certain TRPV2 haplotypes may have a protective role against FM and that some genotypes and haplotypes of TRPV3 contribute towards the symptoms of FM.
OBJECTIVE: Researchers continue to gather evidence that transient receptor potential vanilloid (TRPV) channels contribute towards pain signalling pathways. However, it is unknown whether polymorphisms of the TRPV gene are associated with FM. For the first time, we investigated the association between the polymorphisms of the TRPV2 and TRPV3 genes, FM susceptibility and the severity of the symptoms. METHODS: A total of 409 patients with FM and 423 controls were enrolled from 10 medical centres that participated in the Korean nationwide FM survey. The alleles and genotypes at three positions [rs3813768(C > G), rs8121(C > T) and rs1129235(C > A)] in the TRPV2 gene and two positions [rs7216486 (G > A) and rs395357(C > T)] in the TRPV3 gene were genotyped. RESULTS: The frequencies of the alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with FM susceptibility. However, the GTA haplotype of TRPV2 showed a defence against FM susceptibility (P = 0.035). In addition, polymorphisms of TRPV3 were associated with symptom severity in FM patients. The single nucleotide polymorphism rs395357 of TRPV3 was associated with the scores of the Brief Fatigue Inventory (P = 0.017) in FM patients. Furthermore, haplotypes of TRPV3 were associated with the Brief Fatigue Inventory and the 36-item Short-Form Health Survey mental health summary scores (P = 0.036). CONCLUSION: This study was the first to evaluate the associations of TRPV gene polymorphisms with FM. Our results suggest that certain TRPV2 haplotypes may have a protective role against FM and that some genotypes and haplotypes of TRPV3 contribute towards the symptoms of FM.
Authors: F Bulut Arikan; F A Özdemir; D Şen; S Erdem; S Yörübulut; H Doğan; L Keskin Journal: Acta Endocrinol (Buchar) Date: 2020 Jan-Mar Impact factor: 0.877
Authors: Jörn Lötsch; Dario Kringel; Gerd Geisslinger; Bruno G Oertel; Eduard Resch; Sebastian Malkusch Journal: Int J Mol Sci Date: 2020-06-19 Impact factor: 5.923