Keith B Burt1, Robert Whelan2, Patricia J Conrod3,4, Tobias Banaschewski5, Gareth J Barker3, Arun L W Bokde6, Uli Bromberg7, Christian Büchel7, Mira Fauth-Bühler8, Herta Flor5, André Galinowski9,10, Juergen Gallinat11, Penny Gowland12, Andreas Heinz11, Bernd Ittermann13, Karl Mann8, Frauke Nees5, Dimitri Papadopoulos-Orfanos14, Tomas Paus15,16,17, Zdenka Pausova18, Luise Poustka19, Marcella Rietschel5, Trevor W Robbins20, Michael N Smolka21, Andreas Ströhle11, Gunter Schumann3,22, Hugh Garavan23,2,24. 1. Department of Psychology, University of Vermont, Burlington, VT, USA. Keith.Burt@uvm.edu. 2. Department of Psychology, University College Dublin, Dublin, Ireland. 3. Institute of Psychiatry, King's College London, London, UK. 4. Department of Psychiatry, CHU Ste Justine Hospital, Université de Montréal, Montreal, QC, Canada. 5. Department of Cognitive and Clinical Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 6. Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland. 7. Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany. 8. Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 9. Institut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 'Imaging & Psychiatry', University Paris Sud, Orsay, France. 10. AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris, France. 11. Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany. 12. School of Physics and Astronomy, University of Nottingham, Nottingham, UK. 13. Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany. 14. Neurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France. 15. Rotman Research Institute, University of Toronto, Toronto, ON, Canada. 16. School of Psychology, University of Nottingham, Nottingham, UK. 17. Montreal Neurological Institute, McGill University, Montréal, QC, Canada. 18. The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. 19. Department of Child and Adolescent Psychiatry and Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 20. Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK. 21. Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany. 22. MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK. 23. Department of Psychology, University of Vermont, Burlington, VT, USA. 24. Department of Psychiatry, University of Vermont, Burlington, VT, USA.
Abstract
BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. METHODS: 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. RESULTS: The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. CONCLUSIONS: We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.
BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. METHODS: 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. RESULTS: The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. CONCLUSIONS: We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.
Authors: Adam T Schmidt; Hannah M Lindsey; Emily Dennis; Elisabeth A Wilde; Brian D Biekman; Zili D Chu; Gerri R Hanten; Dana L Formon; Matthew S Spruiell; Jill V Hunter; Harvey S Levin Journal: Cogn Behav Neurol Date: 2021-12-02 Impact factor: 1.600
Authors: Eleanor M Schuttenberg; Jennifer T Sneider; David H Rosmarin; Julia E Cohen-Gilbert; Emily N Oot; Anna M Seraikas; Elena R Stein; Arkadiy L Maksimovskiy; Sion K Harris; Marisa M Silveri Journal: Front Hum Neurosci Date: 2022-02-28 Impact factor: 3.169
Authors: Karen D Ersche; Chun Meng; Hisham Ziauddeen; Jan Stochl; Guy B Williams; Edward T Bullmore; Trevor W Robbins Journal: Proc Natl Acad Sci U S A Date: 2020-06-15 Impact factor: 11.205
Authors: Konstantinos Ioannidis; Adrian Dahl Askelund; Rogier A Kievit; Anne-Laura van Harmelen Journal: BMC Med Date: 2020-02-13 Impact factor: 11.150