Literature DB >> 27076410

Circumferential resection margins and perineal complications after neoadjuvant long-course chemoradiotherapy followed by extralevator abdominoperineal excision of the rectum: Five years of activity at a single institution.

Gianpiero Gravante1, Anur Miah1, Christopher D Mann2, James Andrews Stephenson3, Mohamed Akil Dilawar Gani1, David Sharpe1, Michael Norwood1, Kirsten Boyle1, Andrew Miller1, David Hemingway1.   

Abstract

BACKGROUND: Prone extralevator abdominoperineal excision of the rectum (ELAPE) has been introduced to improve the circumferential resection margins (CRM) compared with traditional APER.
OBJECTIVE: We present short-term results achieved with prone ELAPE preceded by neoadjuvant chemoradiotherapy during the last 5 years of activity.
DESIGN: A retrospective review was conducted. SETTINGS AND PATIENTS: Prone ELAPE operations performed between September 2010 and August 2014 at Leicester Royal Infirmary preceded by neoadjuvant chemoradiotherapy. INTERVENTIONS AND MAIN OUTCOME MEASURES: Data regarding demographics, staging, neoadjuvant therapies, intraoperative perforations, and perineal complications were collected.
RESULTS: Seventy-two patients were included. Pretreatment radiological T4 were 25.0%, histological T4 2.8%. Intraoperative perforations occurred in 2.8%, CRM was involved in 11.1%. Perineal complications consisted of superficial wound infections (20.8%), full thickness dehiscences (16.7%), hematomas (9.7%), pelvic collections (6.9%), and perineal hernias (5.6%).
CONCLUSIONS: In our experience, prone ELAPE preceded by long-course chemoradiotherapy has been successfully used in the last 5 years to resect low rectal tumors. Perineal wound complications rates are similar to those presented in series using direct perineal closures. J. Surg. Oncol. 2016;114:86-90.
© 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Entities:  

Keywords:  circumferential margin; extralevator abdominoperineal resection; long-course chemoradiotherapy

Mesh:

Year:  2016        PMID: 27076410     DOI: 10.1002/jso.24257

Source DB:  PubMed          Journal:  J Surg Oncol        ISSN: 0022-4790            Impact factor:   3.454


  2 in total

1.  Extralevator versus standard abdominoperineal excision in locally advanced rectal cancer: a retrospective study with long-term follow-up.

Authors:  Anu Carpelan; J Karvonen; P Varpe; A Rantala; A Kaljonen; J Grönroos; H Huhtinen
Journal:  Int J Colorectal Dis       Date:  2018-02-14       Impact factor: 2.571

2.  Long-term outcomes after extra-levator versus conventional abdominoperineal excision for low rectal cancer.

Authors:  Haoyu Zhang; Ganbin Li; Ke Cao; Zhiwei Zhai; Guanghui Wei; Chunxiang Ye; Baocheng Zhao; Zhenjun Wang; Jiagang Han
Journal:  BMC Surg       Date:  2022-06-22       Impact factor: 2.030

  2 in total

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