Literature DB >> 27076308

Alphavirus-Based Vaccines.

Kenneth Lundstrom1.   

Abstract

Alphavirus vectors based on Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been widely applied for vaccine development. Naked RNA replicons, recombinant viral particles, and layered DNA vectors have been subjected to immunization in preclinical animal models with antigens for viral targets and tumor antigens. Moreover, a limited number of clinical trials have been conducted in humans. Vaccination with alphavirus vectors has demonstrated efficient immune responses and has showed protection against challenges with lethal doses of virus and tumor cells, respectively. Moreover, vaccines have been developed against alphaviruses causing epidemics such as Chikungunya virus.

Entities:  

Keywords:  Alphaviruses; Cancer vaccines; Immunization; Protection; Viral vaccines

Mesh：

Substances：

Year:  2016        PMID： 27076308     DOI： 10.1007/978-1-4939-3389-1_22

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  6 in total

Review 1.  mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases.

Authors:  Giulietta Maruggi; Cuiling Zhang; Junwei Li; Jeffrey B Ulmer; Dong Yu
Journal:  Mol Ther       Date:  2019-02-07       Impact factor: 11.454

2.  P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages.

Authors:  Tapas Kumar Nayak; Prabhudutta Mamidi; Subhransu Sekhar Sahoo; P Sanjai Kumar; Chandan Mahish; Sanchari Chatterjee; Bharat Bhusan Subudhi; Soma Chattopadhyay; Subhasis Chattopadhyay
Journal:  Front Immunol       Date:  2019-04-12       Impact factor: 7.561

3.  Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice.

Authors:  J Gutiérrez-Álvarez; J M Honrubia; A Sanz-Bravo; E González-Miranda; R Fernández-Delgado; M T Rejas; S Zúñiga; I Sola; L Enjuanes
Journal:  Proc Natl Acad Sci U S A       Date:  2021-10-26       Impact factor: 11.205

Review 4.  Nature of viruses and pandemics: Coronaviruses.

Authors:  Luis Enjuanes; Isabel Sola; Sonia Zúñiga; José M Honrubia; Melissa Bello-Pérez; Alejandro Sanz-Bravo; Ezequiel González-Miranda; Jesús Hurtado-Tamayo; Ricardo Requena-Platek; Li Wang; Diego Muñoz-Santos; Carlos M Sánchez; Ana Esteban; Jorge Ripoll-Gómez
Journal:  Curr Res Immunol       Date:  2022-08-08

5.  Packaging, Purification, and Titration of Replication-Deficient Semliki Forest Virus-Derived Particles as a Self-Amplifying mRNA Vaccine Vector

Authors:  Nastaran Sadat Savar; Thomas Vallet; Arash Arashkia; Kenneth Lundstrom; Marco Vignuzzi; Hamid Mahmoudzadeh Niknam
Journal:  Iran Biomed J       Date:  2022-07-01

6.  Virus-Like Vesicles Based on Semliki Forest Virus-Containing Rabies Virus Glycoprotein Make a Safe and Efficacious Rabies Vaccine Candidate in a Mouse Model.

Authors:  Chengguang Zhang; Yuling Tian; Chen Chen; Zongmei Wang; Jie Pei; Chuhan Lin; Ming Zhou; Zhen F Fu; Ling Zhao
Journal:  J Virol       Date:  2021-08-04       Impact factor: 5.103
  6 in total

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