Literature DB >> 27076069

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.

Ryan J O Dowling1, Sonya Lam2, Christian Bassi3, Samar Mouaaz2, Ahmed Aman4, Taira Kiyota4, Rima Al-Awar4, Pamela J Goodwin5, Vuk Stambolic6.   

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Year:  2016        PMID： 27076069     DOI： 10.1016/j.cmet.2016.03.006

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


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1.  Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.

Authors:  Jessica J Howell; Kristina Hellberg; Marc Turner; George Talbott; Matthew J Kolar; Debbie S Ross; Gerta Hoxhaj; Alan Saghatelian; Reuben J Shaw; Brendan D Manning
Journal:  Cell Metab       Date:  2017-01-12       Impact factor: 27.287

2.  AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells.

Authors:  Riley A Hampsch; Jason D Wells; Nicole A Traphagen; Charlotte F McCleery; Jennifer L Fields; Kevin Shee; Lloye M Dillon; Darcy B Pooler; Lionel D Lewis; Eugene Demidenko; Yina H Huang; Jonathan D Marotti; Abigail E Goen; William B Kinlaw; Todd W Miller
Journal:  Clin Cancer Res       Date:  2020-04-22       Impact factor: 12.531

3.  Targeting liver stage malaria with metformin.

Authors:  Iset Medina Vera; Margarida T Grilo Ruivo; Leonardo F Lemos Rocha; Sofia Marques; Sangeeta N Bhatia; Maria M Mota; Liliana Mancio-Silva
Journal:  JCI Insight       Date:  2019-12-19

Review 4.  Mitochondrial Metabolism as a Target for Cancer Therapy.

Authors:  Karthik Vasan; Marie Werner; Navdeep S Chandel
Journal:  Cell Metab       Date:  2020-07-14       Impact factor: 27.287

5.  Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.

Authors:  Xiaojing Liu; Iris L Romero; Lacey M Litchfield; Ernst Lengyel; Jason W Locasale
Journal:  Cell Metab       Date:  2016-10-13       Impact factor: 27.287

6.  Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors.

Authors:  Jang Hyun Park; Hyun-Jin Kim; Chae Won Kim; Hyeon Cheol Kim; Yujin Jung; Hyun-Soo Lee; Yunah Lee; Young Seok Ju; Ji Eun Oh; Sung-Hong Park; Jeong Ho Lee; Sung Ki Lee; Heung Kyu Lee
Journal:  Nat Immunol       Date:  2021-02-11       Impact factor: 25.606

7.  Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model.

Authors:  Neeta L Vora; Matthew R Grace; Lisa Smeester; Sarah K Dotters-Katz; Rebecca C Fry; Victoria Bae-Jump; Kim Boggess
Journal:  Reprod Sci       Date:  2018-07-05       Impact factor: 3.060

8.  Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice.

Authors:  Noton K Dutta; Michael L Pinn; Petros C Karakousis
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

Review 9.  A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer.

Authors:  Ayesha S Khan; Daniel E Frigo
Journal:  Nat Rev Urol       Date:  2017-02-01       Impact factor: 14.432

Review 10.  Metformin and Breast Cancer: Molecular Targets.

Authors:  J Faria; G Negalha; A Azevedo; F Martel
Journal:  J Mammary Gland Biol Neoplasia       Date:  2019-03-22       Impact factor: 2.673
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