Jiangfan Zhu1, Radheshyam Gupta2, Mahmood Safwa3. 1. Chief of Bariatric and Metabolic Surgery, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Pudong, Shanghai, China. zhujiangfan@hotmail.com. 2. Bariatric and Metabolic Surgery, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Pudong, Shanghai, China. 3. East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Pudong, Shanghai, China.
Abstract
BACKGROUND: There is growing evidence that bariatric surgery can lead to remission of metabolic syndrome. But the mechanism by which bariatric surgery alleviates metabolic syndrome is unclear. MATERIALS AND METHODS: Several present hypotheses which include decreased caloric intake following the surgeries, foregut and hindgut hypothesis, bile acid and bacterial flora changes, and proposed gastric center hypothesis were discussed. RESULTS: None of the currently available hypotheses is solely capable to lead to a reasonable explanation regarding improvement of metabolic syndrome by various bariatric surgical procedures. Proposed gastric center hypothesis could give a better explanation of the mechanism. CONCLUSIONS: All the present bariatric surgeries are involved in changes of the stomach. There could be some particular cells on the stomach, which could secrete unknown special hormones, and then lead to control the metabolic process.
BACKGROUND: There is growing evidence that bariatric surgery can lead to remission of metabolic syndrome. But the mechanism by which bariatric surgery alleviates metabolic syndrome is unclear. MATERIALS AND METHODS: Several present hypotheses which include decreased caloric intake following the surgeries, foregut and hindgut hypothesis, bile acid and bacterial flora changes, and proposed gastric center hypothesis were discussed. RESULTS: None of the currently available hypotheses is solely capable to lead to a reasonable explanation regarding improvement of metabolic syndrome by various bariatric surgical procedures. Proposed gastric center hypothesis could give a better explanation of the mechanism. CONCLUSIONS: All the present bariatric surgeries are involved in changes of the stomach. There could be some particular cells on the stomach, which could secrete unknown special hormones, and then lead to control the metabolic process.
Entities:
Keywords:
Bariatric surgery; Gastric center hypothesis; Metabolic syndrome; Obesity
Authors: Eun Kyung Lee; So Young Kim; You Jin Lee; Mi Hyang Kwak; Hak Jin Kim; Il Ju Choi; Soo-Jeong Cho; Young Woo Kim; Jong Yeul Lee; Chan Gyoo Kim; Hong Man Yoon; Bang Wool Eom; Sun-Young Kong; Min Kyong Yoo; Jong Hyock Park; Keun Won Ryu Journal: World J Gastroenterol Date: 2015-01-28 Impact factor: 5.742
Authors: Rohit Kohli; David Bradley; Kenneth D Setchell; J Christopher Eagon; Nada Abumrad; Samuel Klein Journal: J Clin Endocrinol Metab Date: 2013-03-01 Impact factor: 5.958
Authors: Glenn S Gerhard; Amanda M Styer; G Craig Wood; Stephen L Roesch; Anthony T Petrick; Jon Gabrielsen; William E Strodel; Christopher D Still; George Argyropoulos Journal: Diabetes Care Date: 2013-07 Impact factor: 19.112
Authors: Roland E Allen; Tyler D Hughes; Jia Lerd Ng; Roberto D Ortiz; Michel Abou Ghantous; Othmane Bouhali; Philippe Froguel; Abdelilah Arredouani Journal: Theor Biol Med Model Date: 2013-07-13 Impact factor: 2.432
Authors: Maria Paula Carlin Cambi; Giorgio Alfredo Pedroso Baretta; Daniéla De Oliveira Magro; Cesar Luiz Boguszewski; Igor Braga Ribeiro; Pichamol Jirapinyo; Diogo Turiani Hourneaux de Moura Journal: Obes Surg Date: 2021-01-03 Impact factor: 4.129
Authors: Everton Cazzo; Martinho Antonio Gestic; Murillo Pimentel Utrini; Felipe David Mendonça Chaim; Bruno Geloneze; José Carlos Pareja; Elinton Adami Chaim; Daniéla Oliveira Magro Journal: Arq Bras Cir Dig Date: 2016 Nov-Dec