Ho Won Kang1, Sang Keun Lee1, Won Tae Kim1, Seok Joong Yun1, Sang-Cheol Lee1, Wun-Jae Kim1, Eu Chang Hwang2, Seok Ho Kang3, Sung-Hoo Hong4, Jinsoo Chung5, Tae Gyun Kwon6, Hyeon Hoe Kim7, Cheol Kwak7, Seok-Soo Byun8, Yong-June Kim1. 1. Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea. 2. Department of Urology, Chonnam National University Hwasun Hospital, Jeonnam, Korea. 3. Department of Urology, Korea University School of Medicine, Seoul, Korea. 4. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea. 5. Department of Urology, National Cancer Center, Goyang, Korea. 6. Department of Urology, Kyungpook National University College of Medicine, Daegu, Korea. 7. Department of Urology, Seoul National University College of Medicine, Seoul, Korea. 8. Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract
PURPOSE: To assess the risk factors of positive surgical margins (PSM) and the influence of margin status on recurrence in pT1 clear cell renal cell carcinoma (RCC) following partial nephrectomy (PN). MATERIALS AND METHODS: Patients (1,831) with pathologically confirmed stage T1 clear cell RCC were retrospectively analyzed following PN at eight institutions in Korea between 1999 and 2011. Demographics, operative data, pathological margin status, and site of recurrence were analyzed. RESULTS: Resection margins were positive in 31 patients (1.7% of the cohort) on final pathology. None of the clinicopathological parameters were significantly related to the marginal status (all P > 0.05). During a median follow-up of 32.5 months, local recurrences were observed in 0.4% of negative surgical margins. There was no local recurrence in any of the cases with PSM. Distant recurrences developed in 1.7% of negative surgical margins and 3.2% of PSM. There were no significant differences in recurrence-free survival by margin status (P = 0.566). CONCLUSIONS: Our multi-institutional data suggest that marginal status does not influence tumor recurrence risk in pT1 clear cell RCC after PN. Careful surveillance seems to be a sufficient strategy in this clinical scenario. J. Surg. Oncol. 2016;114:70-74.
PURPOSE: To assess the risk factors of positive surgical margins (PSM) and the influence of margin status on recurrence in pT1 clear cell renal cell carcinoma (RCC) following partial nephrectomy (PN). MATERIALS AND METHODS:Patients (1,831) with pathologically confirmed stage T1 clear cell RCC were retrospectively analyzed following PN at eight institutions in Korea between 1999 and 2011. Demographics, operative data, pathological margin status, and site of recurrence were analyzed. RESULTS: Resection margins were positive in 31 patients (1.7% of the cohort) on final pathology. None of the clinicopathological parameters were significantly related to the marginal status (all P > 0.05). During a median follow-up of 32.5 months, local recurrences were observed in 0.4% of negative surgical margins. There was no local recurrence in any of the cases with PSM. Distant recurrences developed in 1.7% of negative surgical margins and 3.2% of PSM. There were no significant differences in recurrence-free survival by margin status (P = 0.566). CONCLUSIONS: Our multi-institutional data suggest that marginal status does not influence tumor recurrence risk in pT1 clear cell RCC after PN. Careful surveillance seems to be a sufficient strategy in this clinical scenario. J. Surg. Oncol. 2016;114:70-74.
Authors: Hugo Otaola-Arca; Alfred Krebs; Hugo Bermúdez; Raúl Lyng; Marcelo Orvieto; Alberto Bustamante; Conrado Stein; Andrés Labra; Marcela Schultz; Mario I Fernández Journal: Ann Surg Oncol Date: 2022-01-06 Impact factor: 5.344
Authors: D Sri; R Thakkar; H R H Patel; J Lazarus; F Berger; R McArthur; H Lavigueur-Blouin; M Afshar; C Fraser-Taylor; P Le Roux; J Liban; C J Anderson Journal: J Robot Surg Date: 2020-09-03