Literature DB >> 2707446

Spontaneous polymerization of the antibiotic peptide magainin 2.

R Urrutia1, R A Cruciani, J L Barker, B Kachar.   

Abstract

We describe here the ability of the magainin 2 peptide to assemble spontaneously into characteristic 13-nm diameter filaments having a 30 nm periodic helical substructure. Optimal conditions for extensive polymerization into filaments of several hundred microns required low pH and high ionic strength. Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities.

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Year:  1989        PMID： 2707446     DOI： 10.1016/0014-5793(89)81230-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  The virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner.

Authors:  Hermann Bultmann; Gary Girdaukas; Glen S Kwon; Curtis R Brandt
Journal:  Antimicrob Agents Chemother       Date:  2010-07-19       Impact factor: 5.191

2.  Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy.

Authors:  B Bechinger; Y Kim; L E Chirlian; J Gesell; J M Neumann; M Montal; J Tomich; M Zasloff; S J Opella
Journal:  J Biomol NMR       Date:  1991-07       Impact factor: 2.835

3.  Atomic force microscopy study of the effect of antimicrobial peptides on the cell envelope of Escherichia coli.

Authors:  M Meincken; D L Holroyd; M Rautenbach
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

4.  Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy.

Authors:  B Bechinger; M Zasloff; S J Opella
Journal:  Protein Sci       Date:  1993-12       Impact factor: 6.725

5.  Identification of serum components that inhibit the tumoricidal activity of amphiphilic alpha helical peptides.

Authors:  K A Peck-Miller; R P Darveau; H P Fell
Journal:  Cancer Chemother Pharmacol       Date:  1993       Impact factor: 3.333

6.  Antimicrobial action of rabbit leukocyte CAP18(106-137).

Authors:  D J Mason; R Dybowski; J W Larrick; V A Gant
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

7.  Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation.

Authors:  R A Cruciani; J L Barker; M Zasloff; H C Chen; O Colamonici
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

8.  Kinetic studies of the action of lactacin F, a bacteriocin produced by Lactobacillus johnsonii that forms poration complexes in the cytoplasmic membrane.

Authors:  T Abee; T R Klaenhammer; L Letellier
Journal:  Appl Environ Microbiol       Date:  1994-03       Impact factor: 4.792

9.  Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin.

Authors:  S L Haynie; G A Crum; B A Doele
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

10.  Destabilization of α-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets.

Authors:  David O Ulaeto; Christopher J Morris; Marc A Fox; Mark Gumbleton; Konrad Beck
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191
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