Literature DB >> 2707442

Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.

C A O'Brian1, D Fan, N E Ward, C Seid, I J Fidler.   

Abstract

In this report, we demonstrate a direct correlation between protein kinase C (PKC) activity and adriamycin (ADR) resistance in mouse fibrosarcoma cells. PKC activity was measured in four murine UV-2237M fibrosarcoma cell lines that differed in the degrees to which they expressed resistance to ADR, which is an inhibitor of PKC. A comparison of the four cell lines revealed a positive correlation between the level of PKC activity and resistance to ADR. Incubation of the cells with the PKC inhibitor H-7 produced a partial reversal of ADR resistance. Taken together, these results suggest a role for PKC in the mechanism of ADR resistance.

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Year:  1989        PMID： 2707442     DOI： 10.1016/0014-5793(89)80257-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

1.  Protein kinases and multidrug resistance.

Authors:  M G Rumsby; L Drew; J R Warr
Journal:  Cytotechnology       Date:  1998-09       Impact factor: 2.058

2.  Inhibition of protein kinase C in multidrug-resistant cells by modulators of multidrug resistance.

Authors:  Y P Hu; J Robert
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

3.  Characteristics of erythroleukemia cells selected for vincristine resistance that have accelerated inducer-mediated differentiation.

Authors:  V M Richon; N Weich; L Leng; H Kiyokawa; L Ngo; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

Review 4.  Effects of phosphorylation of P-glycoprotein on multidrug resistance.

Authors:  U A Germann; T C Chambers; S V Ambudkar; I Pastan; M M Gottesman
Journal:  J Bioenerg Biomembr       Date:  1995-02       Impact factor: 2.945

5.  Reversal of multidrug resistance in murine fibrosarcoma cells by thioxanthene flupentixol.

Authors:  D Fan; G Poste; C Seid; L E Earnest; T Bull; R K Clyne; I J Fidler
Journal:  Invest New Drugs       Date:  1994       Impact factor: 3.850

6.  Selective loss of substrate recognition induced by the tumour-associated D294G point mutation in protein kinase Calpha.

Authors:  C Prévostel; V Alvaro; A Vallentin; A Martin; S Jaken; D Joubert
Journal:  Biochem J       Date:  1998-09-01       Impact factor: 3.857

7.  Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)- hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro.

Authors:  E C Sha; M C Sha; S H Kaufmann
Journal:  Invest New Drugs       Date:  1996       Impact factor: 3.850

8.  In vivo effects of doxorubicin on kinase C in cultured cells.

Authors:  M Otsuka; H Shigeoka; H C Yang
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 9.  Regulation of protein kinase C and role in cancer biology.

Authors:  G C Blobe; L M Obeid; Y A Hannun
Journal:  Cancer Metastasis Rev       Date:  1994-12       Impact factor: 9.264

Review 10.  Studies on low-level MDR cells.

Authors:  G Belvedere; E Dolfini
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058
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