Jost B Jonas1, Liang Xu2, Wen Bin Wei3, Zhe Pan4, Hua Yang2, Leonard Holbach5, Songhomitra Panda-Jonas6, Ya Xing Wang2. 1. Beijing Institute of Ophthalmology Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China 2Department of Ophthalmology, Medical Faculty Mannheim of the. 2. Beijing Institute of Ophthalmology Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China. 3. Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 4. Beijing Institute of Ophthalmology Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China 4Eye Hospital, China Academy of Chinese Medical Sciences, Beij. 5. Department of Ophthalmology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. 6. Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
Abstract
PURPOSE: To examine the relationships between axial length and foveal and peripheral retinal thickness. METHODS: Using optical coherence tomography, foveal retinal thickness was measured in participants of the population-based Beijing Eye Study without optic nerve or macula diseases. Inner and outer nuclear layer thickness as surrogate for retinal thickness was assessed in the fundus periphery in human globes enucleated due to malignant uveal melanoma or painful glaucoma. RESULTS: The study included 1117 individuals with a mean age of 64.2 ± 9.7 years (range: 50-93 years) and mean axial length of 23.4 ± 1.04 mm (range: 20.29-28.68 mm). In multivariate analysis, thicker central foveal thickness was associated with male sex (P < 0.001; standardized regression coefficient beta: -0.13; nonstandardized regression coefficient B: -5.84; 95% confidence interval (CI): -8.56, -3.13); urban region of habitation (P = 0.02; beta: 0.07; B: 3.56; 95% CI: 0.55, 6.57); thinner lens thickness (P = 0.01; beta: -0.08; B: -5.11; 95% CI: -9.01, -1.21); thinner subfoveal choroidal thickness (P = 0.04; beta: -0.07; B: -0.01; 95% CI: -0.03, -0.001); and longer axial length (P < 0.001; beta: 0.18; B: 3.79; 95% CI: 2.41, 5.17). In the same multivariate model, superior, inferior, and temporal foveal thickness was not significantly associated with axial length (P = 0.26, P = 0.19, P = 0.08, respectively), while thicker nasal foveal thickness was associated with longer axial length (P = 0.009; beta: 0.09; B: 1.50; 95% CI: 0.37, 2.62). In the histomorphometric part of the study including 32 eyes (sagittal diameter: 27.0 ± 4.2 mm; range: 22-37 mm), mean thickness of the inner and outer nuclear layers at the equator and at the midpoint equator/posterior pole decreased with longer axial length (P = 0.004; beta: -0.48; and P = 0.02; beta: -0.44, respectively). CONCLUSIONS: Myopic axial globe elongation was associated with retinal thinning in the equatorial and pre-equatorial region, while foveal retinal thickness was mostly unaffected by axial length. It suggests that axial elongation takes place predominantly in the equatorial and pre-equatorial region of the eye.
PURPOSE: To examine the relationships between axial length and foveal and peripheral retinal thickness. METHODS: Using optical coherence tomography, foveal retinal thickness was measured in participants of the population-based Beijing Eye Study without optic nerve or macula diseases. Inner and outer nuclear layer thickness as surrogate for retinal thickness was assessed in the fundus periphery in human globes enucleated due to malignant uveal melanoma or painful glaucoma. RESULTS: The study included 1117 individuals with a mean age of 64.2 ± 9.7 years (range: 50-93 years) and mean axial length of 23.4 ± 1.04 mm (range: 20.29-28.68 mm). In multivariate analysis, thicker central foveal thickness was associated with male sex (P < 0.001; standardized regression coefficient beta: -0.13; nonstandardized regression coefficient B: -5.84; 95% confidence interval (CI): -8.56, -3.13); urban region of habitation (P = 0.02; beta: 0.07; B: 3.56; 95% CI: 0.55, 6.57); thinner lens thickness (P = 0.01; beta: -0.08; B: -5.11; 95% CI: -9.01, -1.21); thinner subfoveal choroidal thickness (P = 0.04; beta: -0.07; B: -0.01; 95% CI: -0.03, -0.001); and longer axial length (P < 0.001; beta: 0.18; B: 3.79; 95% CI: 2.41, 5.17). In the same multivariate model, superior, inferior, and temporal foveal thickness was not significantly associated with axial length (P = 0.26, P = 0.19, P = 0.08, respectively), while thicker nasal foveal thickness was associated with longer axial length (P = 0.009; beta: 0.09; B: 1.50; 95% CI: 0.37, 2.62). In the histomorphometric part of the study including 32 eyes (sagittal diameter: 27.0 ± 4.2 mm; range: 22-37 mm), mean thickness of the inner and outer nuclear layers at the equator and at the midpoint equator/posterior pole decreased with longer axial length (P = 0.004; beta: -0.48; and P = 0.02; beta: -0.44, respectively). CONCLUSIONS: Myopic axial globe elongation was associated with retinal thinning in the equatorial and pre-equatorial region, while foveal retinal thickness was mostly unaffected by axial length. It suggests that axial elongation takes place predominantly in the equatorial and pre-equatorial region of the eye.
Authors: Caroline Brandl; Christiane Brücklmayer; Felix Günther; Martina E Zimmermann; Helmut Küchenhoff; Horst Helbig; Bernhard H F Weber; Iris M Heid; Klaus J Stark Journal: Invest Ophthalmol Vis Sci Date: 2019-04-01 Impact factor: 4.799
Authors: Hai Xia Bai; Ying Mao; Ling Shen; Xiao Lin Xu; Fei Gao; Zhi Bao Zhang; Bin Li; Jost B Jonas Journal: PLoS One Date: 2017-08-02 Impact factor: 3.240