AIM: Currently there is no effective approach to enhance tendon repair, hence we aimed to identify a suitable cell source for tendon engineering utilizing an established clinically relevant animal model for tendon injury. MATERIALS & METHODS: We compared, by in-depth histomorphometric evaluation, the regenerative potential of uncommitted human mesenchymal stem cells (hMSC) and Scleraxis (Scx)-programmed tendon progenitors (hMSC-Scx) in the healing of a full-size of rat Achilles tendon defect. RESULTS: Our analyses clearly demonstrated that implantation of hMSC-Scx, in contrast to hMSC and empty defect, results in smaller diameters, negligible ectopic calcification and advanced cellular organization and matrix maturation in the injured tendons. CONCLUSION: Scaffold-free delivery of hMSC-Scx aids in enhanced repair in a clinically translatable Achilles tendon injury model.
AIM: Currently there is no effective approach to enhance tendon repair, hence we aimed to identify a suitable cell source for tendon engineering utilizing an established clinically relevant animal model for tendon injury. MATERIALS & METHODS: We compared, by in-depth histomorphometric evaluation, the regenerative potential of uncommitted human mesenchymal stem cells (hMSC) and Scleraxis (Scx)-programmed tendon progenitors (hMSC-Scx) in the healing of a full-size of ratAchilles tendon defect. RESULTS: Our analyses clearly demonstrated that implantation of hMSC-Scx, in contrast to hMSC and empty defect, results in smaller diameters, negligible ectopic calcification and advanced cellular organization and matrix maturation in the injured tendons. CONCLUSION: Scaffold-free delivery of hMSC-Scx aids in enhanced repair in a clinically translatable Achilles tendon injury model.
Authors: Felix Dyrna; Philip Zakko; Leo Pauzenberger; Mary Beth McCarthy; Augustus D Mazzocca; Nathaniel A Dyment Journal: Am J Sports Med Date: 2018-11-12 Impact factor: 6.202
Authors: Maria Rita Citeroni; Maria Camilla Ciardulli; Valentina Russo; Giovanna Della Porta; Annunziata Mauro; Mohammad El Khatib; Miriam Di Mattia; Devis Galesso; Carlo Barbera; Nicholas R Forsyth; Nicola Maffulli; Barbara Barboni Journal: Int J Mol Sci Date: 2020-09-14 Impact factor: 5.923
Authors: Ryan C Locke; Eden M Ford; Karin G Silbernagel; April M Kloxin; Megan L Killian Journal: Tissue Eng Part C Methods Date: 2020-10 Impact factor: 3.273
Authors: Marija Lipar; Boris Zdilar; Mario Kreszinger; Marijana Ćorić; Berislav Radišić; Marko Samardžija; Rado Žic; Marko Pećin Journal: Heliyon Date: 2018-09-10