Literature DB >> 27073171

Inducible targeting of cDCs and their subsets in vivo.

Jakob Loschko1, Gereon J Rieke2, Heidi A Schreiber3, Matthew M Meredith3, Kai-Hui Yao3, Pierre Guermonprez4, Michel C Nussenzweig5.   

Abstract

Conventional dendritic cells (cDCs) are essential immune cells linking the innate and adaptive immune system. cDC depletion in mice is an important method to study the function of these cells in vivo. Here we report an inducible in vivo system for cDC depletion in which excision of a loxP flanked Stop signal enables expression of the human diphtheria toxin receptor (DTR) under the control of Zbtb46 (zDC(lSlDTR)). cDCs can be specifically depleted by combining zDC(lSlDTR) mice with a Csf1r(Cre) driver line. In addition, we show that zDC(Cre) mice can be used to produce cDC specific conditional knockout mice (Irf8, Irf4, Notch2) which lack specific subsets of cDCs.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Dendritic cells; In vivo depletion models; zDC

Mesh：

Substances：

Year:  2016        PMID： 27073171      PMCID： PMC4902770          DOI： 10.1016/j.jim.2016.04.004

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  24 in total

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2.  Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

Authors:  Andreas Schlitzer; V Sivakamasundari; Jinmiao Chen; Hermi Rizal Bin Sumatoh; Jaring Schreuder; Josephine Lum; Benoit Malleret; Sanqian Zhang; Anis Larbi; Francesca Zolezzi; Laurent Renia; Michael Poidinger; Shalin Naik; Evan W Newell; Paul Robson; Florent Ginhoux
Journal:  Nat Immunol       Date:  2015-06-08       Impact factor: 25.606

Review 3.  Development of monocytes, macrophages, and dendritic cells.

Authors:  Frederic Geissmann; Markus G Manz; Steffen Jung; Michael H Sieweke; Miriam Merad; Klaus Ley
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4.  Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.

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Journal:  Immunity       Date:  2013-04-18       Impact factor: 31.745

5.  Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.

Authors:  Tobias M Hohl; Amariliz Rivera; Lauren Lipuma; Alena Gallegos; Chao Shi; Mathias Mack; Eric G Pamer
Journal:  Cell Host Microbe       Date:  2009-11-19       Impact factor: 21.023

6.  Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome.

Authors:  Tal Birnberg; Liat Bar-On; Anita Sapoznikov; Michele L Caton; Luisa Cervantes-Barragán; Divine Makia; Rita Krauthgamer; Ori Brenner; Burkhard Ludewig; Damian Brockschnieder; Dieter Riethmacher; Boris Reizis; Steffen Jung
Journal:  Immunity       Date:  2008-12-08       Impact factor: 31.745

7.  Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

Authors:  Matthew M Meredith; Kang Liu; Guillaume Darrasse-Jeze; Alice O Kamphorst; Heidi A Schreiber; Pierre Guermonprez; Juliana Idoyaga; Cheolho Cheong; Kai-Hui Yao; Rachel E Niec; Michel C Nussenzweig
Journal:  J Exp Med       Date:  2012-05-21       Impact factor: 14.307

8.  Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance.

Authors:  Daria Esterházy; Jakob Loschko; Mariya London; Veronica Jove; Thiago Y Oliveira; Daniel Mucida
Journal:  Nat Immunol       Date:  2016-03-28       Impact factor: 25.606

9.  Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.

Authors:  Gary E Grajales-Reyes; Arifumi Iwata; Jörn Albring; Xiaodi Wu; Roxane Tussiwand; Wumesh Kc; Nicole M Kretzer; Carlos G Briseño; Vivek Durai; Prachi Bagadia; Malay Haldar; Jörg Schönheit; Frank Rosenbauer; Theresa L Murphy; Kenneth M Murphy
Journal:  Nat Immunol       Date:  2015-06-08       Impact factor: 25.606

10.  Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.

Authors:  Heidi A Schreiber; Jakob Loschko; Roos A Karssemeijer; Amelia Escolano; Matthew M Meredith; Daniel Mucida; Pierre Guermonprez; Michel C Nussenzweig
Journal:  J Exp Med       Date:  2013-09-16       Impact factor: 14.307
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  26 in total

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Journal:  Mucosal Immunol       Date:  2017-02-15       Impact factor: 7.313

Review 2.  Dendritic cells in central nervous system autoimmunity.

Authors:  Christopher Sie; Thomas Korn
Journal:  Semin Immunopathol       Date:  2016-11-25       Impact factor: 9.623

Review 3.  Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.

Authors:  Elise R Breed; S Thera Lee; Kristin A Hogquist
Journal:  Semin Cell Dev Biol       Date:  2017-08-09       Impact factor: 7.727

4.  CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells.

Authors:  Luke Riggan; Andrew D Hildreth; Marion Rolot; Yung-Yu Wong; William Satyadi; Ryan Sun; Christopher Huerta; Timothy E O'Sullivan
Journal:  Cell Rep       Date:  2020-05-19       Impact factor: 9.423

Review 5.  Functions of Murine Dendritic Cells.

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Journal:  Immunity       Date:  2016-10-18       Impact factor: 31.745

Review 6.  A cardioimmunologist's toolkit: genetic tools to dissect immune cells in cardiac disease.

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7.  IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.

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8.  ZBTB46 defines and regulates ILC3s that protect the intestine.

Authors:  Wenqing Zhou; Lei Zhou; Jordan Zhou; Coco Chu; Chao Zhang; Robbyn E Sockolow; Gerard Eberl; Gregory F Sonnenberg
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9.  Cigarette smoke-induced airspace disease in mice develops independently of HIF-1α signaling in leukocytes.

Authors:  Patrick S Hume; Jazalle McClendon; Katrina W Kopf; Julie W Harral; Joanna M Poczobutt; Alexandra L McCubbrey; Bradford J Smith; Peter M Henson; Susan M Majka; Irina Petrache; William J Janssen
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Review 10.  Genetic models of human and mouse dendritic cell development and function.

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Journal:  Nat Rev Immunol       Date:  2020-09-09       Impact factor: 53.106
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