| Literature DB >> 2707313 |
Y Nomura1, B X Wang, S B Qi, T Namba, S Kaneko.
Abstract
Several biochemical parameters reflecting the degree of senescence were compared between senile-prone (P) and resistant (R) strains of male senescence-accelerated mouse (SAM) at 11 to 12 months of age. Plasma testosterone in SAM-P amounted to half the concentration in SAM-R. In the liver and brain of SAM-P, the content of malondialdehyde (MDA) and the activity of monoamine oxidase B (MAO-B) were significantly higher than those in SAM-R. Moreover, large amounts of fluorescent lipofuscin were detected in the SAM-P liver. Compared with SAM-R, both membrane and cytosolic fractions from the SAM-P liver contained small amounts of protein and showed less activity of superoxide dismutase (SOD). The present findings suggest that the male SAM-P rapidly acquires biochemical changes which are considered to be part of the normal aging process.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2707313 DOI： 10.1016/0531-5565(89)90034-x
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032