Julian Koenig1, Joshua A Rash2, Andrew H Kemp3,4, Reiner Buchhorn5, Julian F Thayer6, Michael Kaess1,7. 1. a Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine , University of Heidelberg , Heidelberg , Germany. 2. b Department of Psychology , University of Calgary , Calgary , AB , Canada. 3. c School of Psychology & Discipline of Psychiatry, University of Sydney , Sydney , Australia. 4. d Department of Psychology, Swansea University , Swansea , UK. 5. e Department of Pediatrics , Caritas-Krankenhaus , Bad Mergentheim , Germany. 6. f Department of Psychology , the Ohio State University , Columbus , OH , USA. 7. g Clinic of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine , University of Heidelberg , Heidelberg , Germany.
Abstract
OBJECTIVES: To quantify evidence on resting-state vagal activity in patients with attention deficit hyperactivity disorder (ADHD) relative to controls using meta-analysis. METHODS: Three electronic databases (PubMed, PsycINFO, CINAHL Plus) were reviewed to identify studies. Studies reporting on any measure of short-term, vagally mediated heart rate variability during resting state in clinically diagnosed ADHD patients as well as non-ADHD healthy controls were eligible for inclusion. RESULTS: Eight studies reporting on 587 participants met inclusion criteria. Random-effect meta-analysis revealed no significant main effect comparing individuals with ADHD (n = 317) and healthy controls (n = 270) (Hedges' g = 0.06, 95% CI: 0.18-0.29, Z = 0.48, P = 0.63; k = 8). Sub-group analysis showed consistent results among studies in adults (k = 2) and children (k = 6) with ADHD. CONCLUSIONS: Unlike a variety of internalising psychiatric disorders, ADHD is not associated with altered short-term measures of resting-state vagal tone.
OBJECTIVES: To quantify evidence on resting-state vagal activity in patients with attention deficit hyperactivity disorder (ADHD) relative to controls using meta-analysis. METHODS: Three electronic databases (PubMed, PsycINFO, CINAHL Plus) were reviewed to identify studies. Studies reporting on any measure of short-term, vagally mediated heart rate variability during resting state in clinically diagnosed ADHDpatients as well as non-ADHD healthy controls were eligible for inclusion. RESULTS: Eight studies reporting on 587 participants met inclusion criteria. Random-effect meta-analysis revealed no significant main effect comparing individuals with ADHD (n = 317) and healthy controls (n = 270) (Hedges' g = 0.06, 95% CI: 0.18-0.29, Z = 0.48, P = 0.63; k = 8). Sub-group analysis showed consistent results among studies in adults (k = 2) and children (k = 6) with ADHD. CONCLUSIONS: Unlike a variety of internalising psychiatric disorders, ADHD is not associated with altered short-term measures of resting-state vagal tone.
Authors: Trevor W K Yung; Cynthia Y Y Lai; Jacob Y C Chan; Shamay S M Ng; Chetwyn C H Chan Journal: Eur Child Adolesc Psychiatry Date: 2019-05-27 Impact factor: 4.785
Authors: Stephanie S J Morris; Erica D Musser; Rachel B Tenenbaum; Anthony R Ward; Joseph S Raiker; Erika K Coles Journal: Res Child Adolesc Psychopathol Date: 2021-10-06