Ruchi R Deshpande1, John DeMarco2, James W Sayre3, Brent J Liu4. 1. Image Processing and Informatics Laboratory, Denney Research Center (DRB) 264 1042 Downey Way, University of Southern California, Los Angeles, CA, 90089-1111, USA. ruchi.deshpande@gmail.com. 2. Department of Radiation Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA. 3. Department of Biostatistics and Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA. 4. Image Processing and Informatics Laboratory, Denney Research Center (DRB) 264 1042 Downey Way, University of Southern California, Los Angeles, CA, 90089-1111, USA.
Abstract
PURPOSE: Clinical data that are generated through routine radiation therapy procedures can be leveraged as a source of knowledge to provide evidence-based decision support for future patients. Treatment planning in radiation therapy often relies on trial-and-error iterations, experience, judgment calls and general guidelines. The authors present a knowledge-driven decision support system that assists clinicians by reducing some of the uncertainties associated with treatment planning and provides quantified empirical estimates to help minimize the radiation dose to healthy critical structures surrounding the tumor. METHODS: A database of retrospective DICOM RT data fuels a decision support engine, which assists clinicians in selecting dose constraints and assessing dose distributions. The first step is to quantify the spatial relationships between the tumor and surrounding critical structures through features that account for distance, volume, overlap, location, shape and orientation. These features are used to identify database cases that are anatomically similar to the new patient. The dose profiles of these database cases can help clinicians to estimate an acceptable dose distribution for the new case, based on empirical evidence. Since database diversity is essential for good system performance, an infrastructure for multi-institutional collaboration was also conceptualized in order to pave the way for data sharing of protected health information. RESULTS: A set of 127 retrospective test cases was collected from a single institution in order to conduct a leave-one-out evaluation of the decision support module. In 72 % of these retrospective test cases, patients with similar tumor anatomy were also found to exhibit similar radiation dose distributions. This demonstrates the system's ability to successfully extract retrospective database cases that can estimate the new patient's dose distribution. CONCLUSION: The radiation therapy treatment planning decision support system presented here can assist clinicians in determining good dose constraints and assessing dose distributions by using knowledge gained from retrospective treatment plans.
PURPOSE: Clinical data that are generated through routine radiation therapy procedures can be leveraged as a source of knowledge to provide evidence-based decision support for future patients. Treatment planning in radiation therapy often relies on trial-and-error iterations, experience, judgment calls and general guidelines. The authors present a knowledge-driven decision support system that assists clinicians by reducing some of the uncertainties associated with treatment planning and provides quantified empirical estimates to help minimize the radiation dose to healthy critical structures surrounding the tumor. METHODS: A database of retrospective DICOM RT data fuels a decision support engine, which assists clinicians in selecting dose constraints and assessing dose distributions. The first step is to quantify the spatial relationships between the tumor and surrounding critical structures through features that account for distance, volume, overlap, location, shape and orientation. These features are used to identify database cases that are anatomically similar to the new patient. The dose profiles of these database cases can help clinicians to estimate an acceptable dose distribution for the new case, based on empirical evidence. Since database diversity is essential for good system performance, an infrastructure for multi-institutional collaboration was also conceptualized in order to pave the way for data sharing of protected health information. RESULTS: A set of 127 retrospective test cases was collected from a single institution in order to conduct a leave-one-out evaluation of the decision support module. In 72 % of these retrospective test cases, patients with similar tumor anatomy were also found to exhibit similar radiation dose distributions. This demonstrates the system's ability to successfully extract retrospective database cases that can estimate the new patient's dose distribution. CONCLUSION: The radiation therapy treatment planning decision support system presented here can assist clinicians in determining good dose constraints and assessing dose distributions by using knowledge gained from retrospective treatment plans.
Entities:
Keywords:
Decision support; Head and neck cancer; Imaging informatics; Radiation therapy
Authors: B Emami; J Lyman; A Brown; L Coia; M Goitein; J E Munzenrider; B Shank; L J Solin; M Wesson Journal: Int J Radiat Oncol Biol Phys Date: 1991-05-15 Impact factor: 7.038
Authors: Joseph O Deasy; Vitali Moiseenko; Lawrence Marks; K S Clifford Chao; Jiho Nam; Avraham Eisbruch Journal: Int J Radiat Oncol Biol Phys Date: 2010-03-01 Impact factor: 7.038
Authors: S B Jensen; A M L Pedersen; A Vissink; E Andersen; C G Brown; A N Davies; J Dutilh; J S Fulton; L Jankovic; N N F Lopes; A L S Mello; L V Muniz; C A Murdoch-Kinch; R G Nair; J J Napeñas; A Nogueira-Rodrigues; D Saunders; B Stirling; I von Bültzingslöwen; D S Weikel; L S Elting; F K L Spijkervet; M T Brennan Journal: Support Care Cancer Date: 2010-03-17 Impact factor: 3.603
Authors: Binbin Wu; Francesco Ricchetti; Giuseppe Sanguineti; Misha Kazhdan; Patricio Simari; Ming Chuang; Russell Taylor; Robert Jacques; Todd McNutt Journal: Med Phys Date: 2009-12 Impact factor: 4.071
Authors: Jason A Efstathiou; Deborah S Nassif; Todd R McNutt; C Bob Bogardus; Walter Bosch; Jeffrey Carlin; Ronald C Chen; Henry Chou; Dave Eggert; Benedick A Fraass; Joel Goldwein; Karen E Hoffman; Ken Hotz; Margie Hunt; Marc Kessler; Colleen A F Lawton; Charles Mayo; Jeff M Michalski; Sasa Mutic; Louis Potters; Christopher M Rose; Howard M Sandler; Gregory Sharp; Wolfgang Tomé; Phuoc T Tran; Terry Wall; Anthony L Zietman; Peter E Gabriel; Justin E Bekelman Journal: J Oncol Pract Date: 2013-05 Impact factor: 3.840
Authors: Sophie C Huijskens; Irma W E M van Dijk; Jorrit Visser; Brian V Balgobind; D Te Lindert; Coen R N Rasch; Tanja Alderliesten; Arjan Bel Journal: Radiat Oncol Date: 2018-09-12 Impact factor: 3.481