| Literature DB >> 27072198 |
Yinan Chen1, Mies J van Steenbergen1, Dandan Li1, Joep B van de Dikkenberg1, Twan Lammers1,2,3, Cornelus F van Nostrum1, Josbert M Metselaar2,3, Wim E Hennink1.
Abstract
The aim of this study is to design a polymeric nanogel system with tailorable degradation behavior. To this end, hydroxyethyl methacrylate-oligoglycolates-derivatized poly(hydroxypropyl methacrylamide) (pHPMAm-Gly-HEMA) and hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide) (pHEMAm-Gly-HEMAm) are synthesized and characterized. pHEMAm-Gly-HEMAm shows faster hydrolysis rates of both carbonate and glycolate esters than the same ester groups of pHPMAm-Gly-HEMA. pHEMAm-Gly-HEMAm nanogels have tailorable degradation kinetics from 24 h to more than 4 d by varying their crosslink densities. It is shown that the release of a loaded macromolecular model drug is controlled by degradation of nanogels. The nanogels show similar cytocompatibility as PLGA nanoparticles and are therefore considered to be attractive systems for drug delivery.Entities:
Keywords: biodegradable; crosslink density; cytocompatibility; drug delivery systems; polymeric nanogels
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Year: 2016 PMID： 27072198 DOI： 10.1002/mabi.201600031
Source DB: PubMed Journal: Macromol Biosci ISSN： 1616-5187 Impact factor: 4.979