Synthesis of Functionalized 1,3,2-Benzodiazaborole Cores Using Bench-Stable Components.

The azaborine motif provides a unique opportunity to develop core isosteres by inserting B-N units in place of C═C bonds within aromatic scaffolds, creating new pseudoaromatic building blocks that retain comparable structural features. Previous synthetic routes to the 1,3,2-benzodiazaborole core have used organoboron dichlorides and boronic acids as the boron precursors. The transformation developed herein utilizes entirely bench stable starting materials, including organotrifluoroborates, enabling a wider array of substrate analogues under facile reaction conditions. Furthermore, physical, structural, and electronic properties of these compounds were explored computationally to understand the influence of the B-N replacement on the structure, aromaticity, and isosteric viability of these analogues.

Introduction

The ability to create isosteric compounds that alter both the bioavailability and reactivity of molecules without significantly modifying the geometrical shape (isostructural) or the electronic distribution (isoelectronic) of that within the parent structure molecule provides a great advantage for drug developn class="Species">menn>t[1] and other chemistry-oriented applications.[2] To that end, B–N isosterism for a carbon–carbon double bond (Figure ) affords an opportunity to create new core isosteric building blocks for aromatic systems (azaborines). Since the initial synthesis of borazine, a completely inorganic isostere of benzene and the first member of the azaborine class,[3] a whole range of azaborines have been prepared.[4a,4b] Further analysis of these cores revealed their unique spectroscopic[4c] and medicinal properties.[4d−4f]

Figure 1

B–N isosterism for C=C bonds.

The n class="Chemical">indolen> structural motif has a demonstrated prominence in biological targets,[5] and therefore accessing isosteric species would be of value for both academic and pharmaceutical applications. Currently, there are two known azaborine isosteres of indole: (i) the 1,3,2-benzodiazaborole (1), where the 2–3 carbon–carbon double bond is replaced by a B–N bond,[6] and (ii) the “fused” B–N indole[7] (2), in which the adjacent bond in the bicycle is exchanged (Figure ). The indole-azaborine 1 is particularly valuable because it provides access to an indole isostere in one step via chelation of a boron species between the amino groups of o-phenylenediamine.[8] Literature reports have revealed the incorporation of different substituents on boron through the use of alkyl-,[8a] trialkyl-,[8b] and dichloroboranes[9a] and, in later contributions, condensation reactions with boronic acids[9b−9e] or electron-deficient boronate esters.[9f] The major limitation of the currently available methods is the required use of air- and/or moisture-sensitive boron precursors that limit the diversity within these indole isosteres.

Figure 2

Indole isosteres.

<span class="Chemical">Indole isosteren>s.

Recently, our group reported the ability to employ bench-stable n class="Chemical">organotrifluoroboratesn>[10] as precursors for the synthesis of closely related 2,1-borazaronaphthalene cores.[11] This straightforward method enabled access to a library of molecules through activation of the organotrifluoroborate precursors using a fluorophile (e.g., chlorosilane reagents)[12] and subsequent reaction with o-aminostyrene derivatives. Application of this strategy to the indole azaborines was envisioned to provide an easily accessible, robust route toward the 1,3,2-benzodiazaborole core in a similar fashion.

Results and Discussion

Synthetic Method

Initial reaction condition screening, using n class="Chemical">o-phenylenediaminen> 3a and phenyltrifluoroborate 4a, indicated that the system established for the 2,1-borazaronaphthalenes[11] could be applied almost directly to the synthesis of 1,3,2-benzodiazaboroles (Table ). As previously observed, silicon tetrachloride could be used to activate a potassium organotrifluoroborate, generating a highly reactive dichloroborane species,[12] providing good conversion to 5a (Table , entry 1). In exploring more user-friendly fluorophiles, which have recently been shown to activate organotrifluoroborates,[13] we noticed that trivalent, electron-poor boron species could also promote the reaction (Table , entries 3–11) but had better effectiveness when used in excess. With boron fluorophiles, initial organotrifluoroborate deprotection generates a difluoroborane species that has significantly poorer reactivity in comparison to the dichloroborane intermediates,[14] thereby requiring excess boron reagent to abstract both of the remaining fluorides. The best results were obtained when using 3 equiv of boron trifluoride ethylamine complex as the fluorophile (Table , entry 9), a particularly appealing reagent because it was the sole reagent tested that was a bench-stable solid.

Table 1

Optimization of Fluorophile for Reaction Conditions

entry	fluorophile	amt, equiv	P:ISa
1	SiCl4	1	4.60
2	TMSCl	1	2.49
3	BCl3 (1.5 M in hexane)	3	4.21
4	BH3·SMe2	3	1.21
5	BF3·CH3CN	3	1.85
6	BF3·SMe2	3	1.60
7	BF3·THF	3	0.42
8	BF3·OEt2	3	0.43
9	BF3·NH2Et	3	6.85
10	BF3·NH2Et	2	5.55
11	BF3·NH2Et	1	3.80

Product (P) to internal standard (IS) ratios determined by GCMS using 4,4′-di-tert-butylbiphenyl as internal standard.

These modified reaction conditions were then applied to prepare n class="Chemical">1,3,2-benzodiazaborolen> analogues using various potassium aryltrifluoroborates (Table ). In addition to alkyl groups (5b–d) and halogens (5e–g), the relatively mild reaction conditions enabled vinyl (5h), ether (5i–l,n) and ester (5m) functional groups to be tolerated. Whereas steric hindrance at either the ortho position of the aryltrifluoroborate (5b,c,e,i,l) or on one of the diamine nitrogen atoms (5d,g,s) did not deeply affect the reaction, the presence of some electron-withdrawing substituents such as nitro (5o) or cyano (5p) groups resulted in lower yields. Heteroaryltrifluoroborates containing sulfur (5q) or oxygen (5r,s) atoms were well tolerated. Unfortunately, the method could not be extended to nitrogen-containing heteroaryls such as pyridyl subunits (5t).

Table 2

Scope of Reaction with (Hetero)aryltrifluoroboratesc

Reaction run under ambient atmosphere.

Reaction run on 30 mmol scale.

Reaction conditions: 1.0 equiv of diamine, 1.0 equiv of potassium organotrifluoroborates, 3.0 equiv of BF3·NH2Et, 1/1 toluene/CPME (0.5 M), 80 °C, 18 h.

Reaction conditions: 1.0 equiv of n class="Chemical">diaminen>, 1.0 equiv of potassium organotrifluoroborates, 3.0 equiv of BF3·NH2Et, 1/1 toluene/CPME (0.5 M), 80 °C, 18 h.

The utility of this protocol, using all air-stable starting materials, consequently allowed the reaction to proceed even in the absence of an n class="Chemical">argonn> purge of the reaction vessel or solvents (88% under air versus 90% under argon for 5a). It is of note that, for several of the reactions, the only purification required was a basic aqueous (saturated NaHCO3) workup followed by extraction with ethyl acetate, highlighting the ease of access toward these cores. In most remaining cases, the only additional purification required was passage through a flash plug of silica gel.

Desymmetrization of the starting n class="Chemical">phenylenediaminen> enabled the synthesis of unsymmetrical azaborine cores (Table ). Use of functionalized phenylenediamines allowed the facile introduction of versatile synthetic handles such as bromo (5w), carbonyl (5x), and nitro (5y) groups. Some difficulty was encountered when using 2,3-naphthalenediamine (5z), presumably because of the heterogeneity of the reaction mixture under these reaction conditions.

Table 3

Scope of Reaction with Substituted o-Phenylenediaminesa

Reaction conditions: 1.0 equiv of diamine, 1.0 equiv of trifluoroborates, 3.0 equiv of BF3·NH2Et, 1/1 toluene/CPME (0.5 M), 80 °C, 18 h.

Reaction conditions: 1.0 equiv of n class="Chemical">diaminen>, 1.0 equiv of trifluoroborates, 3.0 equiv of BF3·NH2Et, 1/1 toluene/CPME (0.5 M), 80 °C, 18 h.

The scope of the method was further advanced to other Csp-hybridized as well as Cn class="Chemical">sp-hybridized groups on the boron atom (Table ). Alkenyltrifluoroborates were well tolerated under these conditions (Table , left), affording the corresponding azaborines in good yields (6a–c). An alkynyltrifluoroborate was also utilized to exhibit that the procedure could be extended to sp-hybridized centers (6d). N-Methylation of the diamine did not affect the reaction (6e,f), and the presence of a bulky N-phenyl group was tolerated when using sterically small organotrifluoroborates (6g,h). However, only starting diamine was observed when attempting to cyclize such substrates with larger aliphatic or aryl substituents on the organoboron precursors.

Table 4

Scope of Reactions of Alkyl- and Alkenyltrifluoroboratesa

Reaction conditions: 1.0 equiv of diamine, 1.0 equiv of organotrifluoroborates, 3.0 equiv of BF3·NH2Et, 1/1 toluene/CPME (0.5 M), 80 °C, 18 h.

Reaction conditions: 1.0 equiv of n class="Chemical">diaminen>, 1.0 equiv of organotrifluoroborates, 3.0 equiv of BF3·NH2Et, 1/1 toluene/CPME (0.5 M), 80 °C, 18 h.

Substituted n class="Chemical">azaborinen> compounds with Csp-hybridized units on the boron (Table , right) were found to be less stable than their Csp-hybridized counterparts. The B-alkyl compounds, when subjected to the standard workup, readily decomposed in the presence of water. This problem was overcome by foregoing the aqueous workup and directly subjecting the reaction mixture to a flash plug of silica, allowing access to pure material in moderate (7c) to good yields (7g). Once isolated and stored as solids on the benchtop, no degradation of the products were observed. Using this modified workup procedure, primary (7a,e–h), secondary (7b,c), and tertiary (7d) alkyl substituted azaborines were isolated. N-Alkylated diamines could be used as reaction partners, affording the corresponding azaborines, often in very good yields (7f–h).

Physical Properties and Computationally Derived Results

With the primary objective of the project achieved (developn class="Species">menn>t of a straightforward method of synthesis of the 1,3,2-benzodiazaborole core involving only bench-stable partners), attention was next focused on understanding the potential value and versatility of these indole isosteres. Initially, the pKa value of the azaborine N–H was determined via bracketing experiments (see the Supporting Information), and a pKa of roughly 18.2 (in DMSO) was found for the monoalkylated derivative 5d. This value falls slightly lower than the pKa for indole (20.9)[15] and significantly below that of the “fused” B–N indole (around 30).[7] Considering the pKa for aniline (30.6) or phenylacetamide (21.5), the lower pKa suggests that the 1,3,2-benzodiazaborole anion is better at inductively stabilizing the negative charge generated on deprotonation.

Computational models were further studied as a means of assessing the structural and electronic correlation between <span class="Chemical">azaborinen> cores and <span class="Chemical">indole. Liu,[16] and more recently Northrop,[9e] previously looked at various computational methods for analyzing the core of the <span class="Chemical">indole-azaborine systems, but we were primarily interested in the effect caused by substitution around the core. All calculations were carried out using Gaussian 09,[17] and the structures were visualized via WebMO.[18] Geometry optimizations were performed in the gas phase at the B3LYP/6-311+G(2d,p) level of theory.[19] Stationary points were characterized by frequency analysis at 298 K. To probe the ring current in these systems, NICS values were determined at the GIAO-B3LYP/6-311+G(2d,p) level of theory at distances of 0.0 Å [A(0) and B(0)] and 1 Å [A(1) and B(1)] from each ring system as well from the center of the bicyclic systems [Center(1)] in the perpendicular direction (Figure ).

Figure 3

NICS values calculated.

We first evaluated the electrostatic potentials of n class="Chemical">indolen> azaborines and their carbon analogues (Figure ). A pictorial comparison of the electrostatic potential maps for both the 1,3,2-benzodiazaborole core and the “fused” B–N indole core explored by Liu[7] to similar 6–5 aromatic ring systems indicated that they most closely resemble the indole framework. It is thus visually apparent that both azaborines present a greater likeness to indole [compare 2-methylindole (8a) and 2-methylbenzimidazole (9) to their azaborine analogues 7a and 2a], supporting the notion that the B–N bond displays some of the electronic properties of a C=C bond. An even stronger likeness can be seen on comparison of N-alkylated azaborines 8b,c to 7f and 2b, respectively. The strong similarity between the electrostatic potential maps in these isosteric systems presumably results from enhanced electron availability from the methylated nitrogen within the five-membered ring. In the case of 7f, although this would enhance electron density, it would also reduce competitive conjugation of the lone pairs of the now desymmetrized nitrogen atoms. Quantitatively, this is observed by a slight lengthening of the MeN–B bond (1.439 Å) in comparison to the HN–B bond (1.435 Å). This factor is also noticed in the indole and “fused” B–N indole, though to lesser extents (see the Supporting Information for a full bond length table). When taken together, these factors lead to an electronic hybrid between 8c and 8b where the dimethylated 1,3,2-benzodiazaborole core closely resembles the A ring of 8b while having a B ring more similar to that of 8c.

Figure 4

Electrostatic potentials (from +31.38 to −31.38 kcal/mol) of the 1,3,2-benzodiazaborole in comparison to indole.

Electrostatic potentials (from +31.38 to −31.38 kcal/mol) of the <span class="Chemical">1,3,2-benzodiazaborolen> in comparison to <span class="Chemical">indole.

Nuclear independent chemical shift (n class="Chemical">NICS) calculations[20] were performed to assess the relative aromatic character of each ring (Table ). NICS calculations provide quantitative correlations for aromaticity using “theoretical nuclei” at the center of a ring system to probe electron shielding.[20] A more negative NICS value indicates greater electron shielding via a stronger ring current and thus more π-electron delocalization. Enhanced delocalization is indicative of greater aromatic character. Because of ring current effects, only rings of similar size can be compared.[21] Across a selection of several molecules (Table ), a few preliminary trends for the indole-azaborines can be ascertained. Initially, an increase in aromaticity in the A ring from o-phenylenediamine 3 to the cyclized azaborine products was observed, presumably caused by the nitrogen lone pairs becoming locked in plane with the rest of the π cloud upon annulation. Furthermore, the A rings of the 1,3,2-benzodiazaborole 7a share values similar to those for the corresponding indole 8a and benzimidazole 9. However, on examination of the B ring, there is a lower electron shielding effect for the azaborine, presumably caused by incomplete π delocalization with the B–N bond. This is confirmed by the NICS calculation for “fused” B–N indole 2a, where lower electron shielding occurs in both rings caused by the conjoined B–N bond. Similar values for related compounds have been observed by Liu.[16] Furthermore, B-ring deshielding is perturbed by the hybridization of groups bound to boron (5a–7a, 6d), presumably caused by orbital overlap or the electron-donating character of these functional groups. This hybridization effect has been previously observed within the benzene-azaborine scaffold,[22] where sp-hybridized groups generally induce shielding relative to its phenyl counterpart.

Table 5

NICS Comparisons (ppm) of 1,3,2-Benzodiazaborole and Its Relative Carbon Isosteresa

All structures are fully optimized to local minima (B3LYP/6-311+G(2d,p)).

Conclusions

The synthetic approach to the n class="Chemical">1,3,2-benzodiazaborolesn> described highlights the ability to synthesize these azaborine cores via bench-stable reagents in a facile procedure, tolerant to atmospheric conditions. Furthermore, the simple workup and purification conditions employed enable rapid access to molecules with valuable isosteric potential. The physical and computational data suggest that this class of azaborine compounds demonstrates some aromatic tendencies, which could be leveraged for potential application of this core isostere of indole.

Experimental Section

General Considerations

All reactions were carried out under an inert atmosphere of <n class="Chemical">span class="Chemical">argon in oven-dried glassware, unless otherwise noted. <spn>an class="Chemical">Toluene and cyclopentyl methyl ether (CPME) were dried using a J. C. Meyer solvent system. o-Phenylenediamine (99%) was recrystallized from toluene. Standard flash chromatography procedures were followed using 32–63 μm silica gel. Column chromatography was performed by Combiflash using RediSep Rf Gold Normal-Phase Silica columns. Melting points (°C) are uncorrected. HRMS data were obtained by either ESI or CI using a TOF mass spectrometer in CH2Cl2 or MeCN as the solvent. NMR spectra (1H, 13C, 11B, 19F) were performed at 298 K. 1H (500.4 MHz) and 13C (125.8 MHz) NMR chemical shifts are reported relative to internal TMS (δ 0.00 ppm) or to residual protiated solvent. 11B (128.4 MHz) and 19F NMR (282.4 MHz) chemical shifts were referenced to external BF3·Et2O (0.0 ppm) and CFCl3 (0.0 ppm), respectively. Data are presented as follows: chemical shift (ppm), multiplicity (s = singlet, d = doublet, t = triplet, q = quartet, sept = septet, m = multiplet), coupling constant J (Hz), and integration.

General Procedure for Synthesis of Aryl 1,3,2-Benzodiazaboroles 5a–z

n class="Chemical">Diaminen> (1 equiv, 1 mmol), organotrifluoroborate (1 equiv, 1 mmol), and BF3·NH2Et (3 equiv, 3 mmol) were added to an oven-dried Biotage microwave vial with a stir bar. The vial was sealed with a cap, which was lined with a disposable Teflon septum, and the reaction vessel was subsequently evacuated and purged three times with argon. A 1/1 mixture of CPME (1 mL) and toluene (1 mL) was added, and the reaction mixture was heated to 80 °C. After it was stirred overnight, the reaction mixture was diluted with 5 mL of saturated NaHCO3 and extracted with EtOAc (2 × 5 mL). The organic phase was washed with brine and dried (MgSO4), before being condensed under vacuum to afford the azaborine.

2-Phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole[9d] (5a)

Thirty millimole scale reaction in a 200 mL round-bottom flask. Obtained as a tan solid (4.949 g, 85%). Mp: 198–200 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.76–7.74 (m, 2H), 7.49–7.41 (m, 3H), 7.14 (dd, J = 5.3, 3.4 Hz, 2H), 6.99 (ddd J = 5.6, 3.3 Hz, 0.9 Hz, 2H), 6.79 (s, 2H). 13C NMR (125.8 MHz, CDCl3): δ 136.4, 133.2, 129.9, 128.3, 119.5, 111.3. 11B NMR (128.4 MHz, MeCN): δ 28.5. IR (neat): 3441, 3418, 1421, 746, 699, 597 cm–1. HRMS (ESI) m/z: calcd for C12H12BN2 [M + H]+ 195.1094, found 195.1100.

2-(o-Tolyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole[23] (5b)

Obtained as a tan solid (173 mg, 83%). Mp: 107–110 °C. <span class="Chemical">1Hn> NMR (500.4 MHz, <span class="Chemical">CDCl3): δ 7.65 (d, J = 7.3 Hz, <span class="Chemical">1H), 7.36 (t, J = 7.3 Hz, 1H), 7.28 (d, J = 7.3 Hz, 2H), 716 (dd, J = 5.6, 3.4 Hz, 2H), 7.02 (dd, J = 5.6, 3.4 Hz, 2H), 6.73 (s, 2H), 2.59 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 142.0, 136.2, 134.4, 130.0, 129.6, 125.4, 119.5, 111.2, 23.1. 11B NMR (128.4 MHz, MeCN): δ 28.6. IR (neat): 3457, 3423, 1605, 1416, 1351, 740, 612 cm–1. HRMS (CI) m/z: calcd for C13H14BN2 [M + H]+ 209.1250, found 209.1242.

2-(2,6-Dimethylphenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5c)

Obtained as a tan solid (186 mg, 84%). Mp: 124–126 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.24 (t, J = 7.7 Hz, 1H), 7.15 (dd, 5.4, 3.6 Hz, 2H), 7. 08 (d, J = 7.7 Hz, 2H), 7.01 (dd, J = 5.4, 3.4 Hz, 2H), 6.54 (s, 2H), 2.33 (s, 6H). 13C NMR (125.8 MHz, CDCl3): δ 141.8, 136.2, 128.9, 126.4, 119.3, 111.2, 23,2. 11B NMR (128.4 MHz, MeCN): δ 29.5. IR (neat): 3421, 3054, 2925, 1440, 1352, 739, 617 cm–1. HRMS (CI) m/z: calcd for C14H14BN2 [M – H]− 221.1250, found 221.1257.

1-Methyl-2-phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole[9c] (5d)

Three mmol scale reaction in a 20 mL microwave vial. Obtained as a <span class="Chemical">darkn> red solid (171 mg, 82%). Mp: 84–88 °C. <span class="Chemical">1H NMR (500.4 MHz, <span class="Chemical">CDCl3): δ 7.74–7.70 (m, 2H), 7.47–7.44 (m, 3H), 7.18–7.07 (m, 3H), 7.03 (td, J = 7.6, 1.3 Hz, 1H), 6.66 (s, 1H), 3.52 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 139.1, 135.9, 133.8, 129.2, 128.2, 119.3, 119.3, 110.1, 106.8, 30.0. 11B NMR (128.4 MHz, MeCN): δ 28.8. IR (neat): 3431, 3054, 3045, 1409, 736, 703, 587 cm–1. HRMS (CI) m/z: calcd for C13H13BN2 [M]+ 208.1172, found 208.1172.

2-(2,6-Difluorophenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5e)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4:1) as eluent. Obtained as a tan solid (154 mg, 67%). Mp: 148–151 °C. 1H NMR (500.4 MHz, DMSO-d6): δ 9.01 (s, 2H), 7.54 (tt, J = 8.2, 6.9 Hz, 1H), 7.18 (dd, J = 5.7, 3.3 Hz, 2H), 7.16–7.12 (m, 2H), 6.96–6.74 (m, 2H). 13C NMR (125.8 MHz, CDCl3): δ 167.0 (dd, J = 247.5, 13.4 Hz), 135.7, 132.2 (t, J = 11.3 Hz), 119.7, 111.5, 111.4 (dd, J = 23.1, 5.6 Hz). 11B NMR (128.4 MHz, MeCN): δ 24.6. 19F NMR (282.4 MHz, CDCl3): δ −103.0. IR (neat): 3450, 3054, 1624, 1453, 979, 779, 735, 590 cm–1. HRMS (CI) m/z: calcd for C12H9BN2F2 [M]+ 230.0827, found 230.0827.

2-(4-Bromophenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole[9c] (5f)

Obtained as a tan solid (184 mg, 68%), Mp: 216–218 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.61–7.54 (m, 4H), 7.12 (dd, J = 5.4, 3.3 Hz, 2H), 6.99 (dd, J = 5.3, 4.4 Hz, 2H), 6.76 (s, 2H). 13C NMR (125.8 MHz, CDCl3): δ 136.3, 134.8, 131.5, 124.5, 119.7, 111.4. 11B NMR (128.4 MHz, MeCN): δ 28.2. IR (neat): 3418, 1584, 1427, 1275, 751, 599 cm–1. HRMS (CI) m/z: calcd for C12H10BN2Br [M]+ 272.0120, found 272.0133.

2-(4-Fluorophenyl)-1-methyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (5g)

Obtained as a brown solid (185 mg, 82%). Mp: 114–115 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.68 (dd, J = 8.8, 5.7 Hz, 2H), 7.19–7.12 (m, 2H), 7.12–7.03 (m, 3H), 7.00 (t, J = 6.8 Hz, 1H), 6.61 (s, 1H), 3.48 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 163.8 (d, J = 248.4 Hz), 139.0, 135.8, 135.6 (d, J = 7.9 Hz), 119.4, 119.4, 115.4 (d, J = 19.9 Hz), 110.9, 108.9, 30.0. 11B NMR (128.4 MHz, MeCN): δ 28.0. 19F NMR (282.4 MHz, CDCl3): δ −112.5. IR (neat): 3437, 3054, 2910, 1596, 1397, 1217, 830, 738, 576 cm–1. HMRS (CI) m/z: calcd for C13H12BN2F [M]+ 226.1078, found 226.1080.

2-(3-Vinylphenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5h)

Obtained as a light brown solid (162 mg, 73%). Mp: 119–121 °C. n class="Chemical">1Hn> NMR (500.4 MHz, DMSO-d6): δ 9.16 (s, 2H), 8.05 (s, 1H), 7.80 (d, J = 7.2 Hz, 1H), 7.48 (d, J = 7.7 Hz, 1H), 7.40 (t, J = 7.5 Hz, 1H), 7.09–7.02 (m, 2H), 6.84–6.81 (m, 2H), 6.77 (dd, J = 17.5, 10.8 Hz, 1H), 5.92 (d, J = 17.6 Hz, 1H), 5.31 (d, J = 10.9 Hz, 1H). 13C NMR (125.8 MHz, DMSO-d6): δ 137.1, 136.9, 136.5, 133.0, 131.1, 128.2, 127.3, 118.3, 114.1, 110.8. 11B NMR (128.4 MHz, MeCN): δ 28.5. IR (neat): 3445, 3425, 3054, 1353, 904, 746, 688, 564 cm–1. HMRS (CI) m/z: calcd for C14H14BN2 [M + H]+ 221.1250, found 221.1244.

2-(2-Methoxyphenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole[24] (5i)

Obtained as a tan solid (175 mg, 78%). Mp: 123–124 °C. n class="Chemical">1Hn> NMR (500.4 MHz, DMSO-d6): δ 8.77 (s, 2H), 7.86 (d, J = 7.2 Hz, 1H), 7.39 (t, J = 7.7 Hz, 1H), 7.11 (dd, J = 5.7, 3.3 Hz, 2H), 7.05–6.95 (m, 2H), 6.81 (dd, J = 5.8, 3.2 Hz, 2H), 3.89 (s, 3H). 13C NMR (125.8 MHz, DMSO-d6): δ 163.2, 136.9, 135.3, 131.0, 120.1, 118.0, 110.7, 110.4, 55.0. 11B NMR (128.4 MHz, MeCN): δ 27.4. IR (neat): 3460, 3423, 1598, 1418, 1243, 743, 619 cm–1. HMRS (CI) m/z: calcd for C13H14BN2O [M + H]+ 225.1199, found 225.1201.

2-(3-Methoxyphenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole[24] (5j)

Product further purified via recrystallization from bn class="Chemical">oiln>ing toluene. Obtained as a brown solid (139 mg, 62%). Mp: 150–152 °C. 1H NMR (500.4 MHz, DMSO-d6): 9.11 (s, 2H), 7.51 (s, 1H), 7.47 (d, J = 7.1 Hz, 1H), 7.33 (td, J = 7.7, 2.1 Hz, 1H), 7.06 (dt, J = 5.6, 2.6 Hz, 2H), 6.96 (d, J = 8.1 Hz, 1H), 6.82 (dt, J = 5.6, 2.7 Hz, 2H), 3.81 (s, 3H). 13C NMR (125.8 MHz, DMSO-d6): δ 156.9, 137.1, 129.0, 125.6, 118.5, 118.3, 115.0, 110.7, 54.9. 11B NMR (128.4 MHz, MeCN): δ 28.4. IR (neat): 3414, 1425, 750, 698, 634 cm–1. HMRS (CI) m/z: calcd for C13H14BN2O [M + H]+ 225.1199, found 225.1201.

2-(3-Methoxyphenyl)-1-methyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (5k)

Obtained as a n class="Chemical">darkn> brown solid (191 mg, 80%). Mp: 86–88 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.40 (t, J = 7.4 Hz, 1H), 7.30 (d, J = 7.4 Hz, 1H), 7.25 (s, 1H), 7.14–7.04 (m, 3H), 7.03–6.97 (m, 2H), 6.66 (s, 1H), 3.87 (s, 3H), 3.51 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 159.4, 139.0, 135.8, 129.5, 126.1, 119.32, 199.31, 119.2, 114.5, 110.9, 108.9, 55.3, 30.0. 11B NMR (128.4 MHz, MeCN): δ 28.4. IR (neat): 3427, 1575, 1402, 1254, 749, 702, 608 cm–1. HMRS (CI) m/z: calcd for C14H16BN2O [M + H]+ 239.1356, found 239.1359.

2-(2-Phenoxyphenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5l)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a brown solid (178 mg, 62%). Mp: 81–83 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.79–7.75 (m, 1H), 7.41–7.32 (m, 3H), 7.17 (dt, J = 11.4, 7.3 Hz, 2H), 7.12–7.07 (m, 4H), 7.03 (s, 2H), 6.96 (d, J = 3.2 Hz, 1H), 6.95 (d, J = 3.3 Hz, 1H), 6.89–6.86 (m, 1H). 13C NMR (125.8 MHz, CDCl3): δ 161.8, 157.2, 136.3, 135.1, 131.4, 130.1, 123.8, 123.3, 119.6, 119.4, 118.1, 111.2. 11B NMR (128.4 MHz, CDCl3): δ 27.1. IR (neat): 3431, 3186, 2946, 2865, 1458, 1274, 738, 575 cm–1. HMRS (CI) m/z: calcd for C18H15BN2ONa [M + Na]+ 309.1175, found 309.1181.

2-(4-(Methoxycarbonyl)phenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5m)

Obtained as a tan solid (130 mg, 51%). Mp: 171–172 °C. n class="Chemical">1Hn> NMR (500.4 MHz, DMSO-d6): δ 9.33 (s, 2H), 8.54 (s, 1H), 8.16 (d, J = 7.9 Hz, 1H), 7.99 (dt, J = 8.1, 1.7 Hz, 1H), 7.58 (td, J = 7.6, 1.7 Hz, 1H), 7.16–7.02 (m, 2H), 6.83 (dt, J = 5.6, 2.5 Hz, 2H), 3.90 (s, 3H). 13C NMR (125.8 MHz, DMSO-d6): δ 166.6, 138.1, 137.1, 134.0, 130.0, 129.3, 128.3, 118.4, 111.0, 52.1. 11B NMR (128.4 MHz, MeCN): δ 28.0. IR (neat): 3424, 3404, 2950, 1701, 1431, 1282, 1263, 741, 690 cm–1. HMRS (CI) m/z: calcd for C14H14BN2O2 [M + H]+ 253.1148, found 253.1137.

2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5n)

Obtained as a tan solid (191 mg, 76%). Mp: 199–201 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.24–7.20 (m, 2H), 7.10 (dd, J = 5.3, 3.4 Hz, 2H), 6.98–6.93 (m, 3H), 6.68 (s, 2H), 4.30 (s, 4H). 13C NMR (125.8 MHz, CDCl3): δ 145.3, 143.6, 136.5, 126.5, 121.9, 119.4, 117.4, 111.1, 64.7, 64.5. 11B NMR (128.4 MHz, MeCN): δ 28.5. IR (neat): 3446, 3416, 2995, 2940, 2875, 1575, 1245, 1126, 745, 547 cm–1. HMRS (CI) m/z: calcd for C14H14BN2O2 [M + H]+ 253.1148, found 253.1157.

2-(3-Nitrophenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole[9c] (5o)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a tan solid (62 mg, 26%). Mp: 210–211 °C. 1H NMR (500.4 MHz, DMSO-d6): δ 9.46 (s, 2H), 8.79 (s, 1H), 8.32 (d, J = 7.1 Hz, 1H), 8.25 (d, J = 7.7 Hz, 1H), 7.74 (t, J = 7.7 Hz, 1H), 7.09 (dd, J = 5.8, 3.1 Hz, 2H), 6.86 (dt, J = 5.7, 3.1 Hz, 2H). 13C NMR (125.8 MHz, DMSO-d6): δ 147.6, 139.7, 136.9, 129.5, 127.5, 123.9, 118.7, 111.1. 11B NMR (128.4 MHz, MeCN): δ 27.7. IR (neat): 3397, 1620, 1429, 1346, 1270, 737, 687 cm–1. HMRS (CI) m/z: calcd for C12H11BN3O2 [M + H]+ 240.0944, found 240.0937.

2-(3-Cyanophenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5p)

Obtained as a tan solid (53 mg, 24%). Mp: 195–196 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 8.01 (s, 1H), 7.94 (dt, J = 7.5, 1.3 Hz, 1H), 7.71 (dt, J = 7.8, 1.5 Hz, 1H), 7.54 (td, J = 7.6, 0.7 Hz, 1H), 7.19–7.13 (m, 2H), 7.01 (dd, J = 5.7, 3.1 Hz, 2H), 6.86 (s, 2H). 13C NMR (125.8 MHz, CDCl3): δ 137.2, 136.7, 136.1, 133.0, 129.0, 120.1, 119.1, 112.7, 111.7. 11B NMR (128.4 MHz, CDCl3): δ 27.6. IR (neat): 3415, 3378, 3065, 2232, 1434, 1273, 745, 693, 561 cm–1. HMRS (CI) m/z: calcd for C13H11BN3 [M + H]+ 220.1046, found 220.1048.

2-(Thiophen-3-yl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5q)

Obtained as a tan solid (128 mg, 64%). Mp: 221–222 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.75–7.73 (m, 1H), 7.45 (dd, J = 4.7, 2.6 Hz, 1H), 7.42 (d, J = 4.6 Hz, 1H), 7.11 (dd, J = 7.5, 3.8 Hz, 2H), 6.97 (dd, J = 5.7, 3.3 Hz, 2H), 6.70 (s, 2H). 13C NMR (125.8 MHz, CDCl3): δ 136.3, 131.9, 131.2, 126.1, 119.5, 111.2. 11B NMR (128.4 MHz, MeCN): δ 26.4. IR (neat): 3427, 1431, 740, 662, 600 cm–1. HMRS (CI) m/z: calcd for C10H9BN2S [M]+ 200.0580, found 200.0601.

2-(2-Benzofuranyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (5r)

Obtained as a tan solid (132 mg, 57%). Mp: 220–222 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.66 (d, J = 7.9 Hz, 1H), 7.56 (d, J = 8.2 Hz, 1H), 7.39–7.32 (m, 1H), 7.29–7.23 (m, 2H), 7.16 (dd, J = 7.4, 3.7 Hz, 2H), 7.01 (dd, J = 5.8, 3.2 Hz, 2H), 6.96 (s, 2H). 13C NMR (125.8 MHz, DMSO-d6): δ 156.5, 136.7, 128.0, 125.0, 122.7, 121.5, 118.7, 115.5, 111.2, 111.1. 11B NMR (128.4 MHz, MeCN): δ 24.8. IR (neat): 3436, 1569, 1411, 1337, 735, 602 cm–1. HMRS (CI) m/z: calcd for C14H12BN2O [M + H]+ 235.1043, found 235.1053.

2-(Furan-2-yl)-1-methyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (5s)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a brown solid (144 mg, 73%). Mp: 73–75 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.75 (s, 1H), 7.60 (d, J = 1.4 Hz, 1H), 7.06–7.03 (m, 3H) 6.99 (dt, J = 7.4, 1.4 Hz, 1H), 6.66 (s, 1H), 6.57 (s, 1H) 3.49 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 147.4, 143.2, 138.9, 119.2, 119.1, 113.2, 110.8, 108.6, 30.0. 11B NMR (128.4 MHz, MeCN): δ 26.4. IR (neat): 3431, 3054, 2947, 1478, 1345, 733, 541 cm–1. HMRS (CI) m/z: calcd for C11H11BN2O [M]+ 198.0964, found 198.0965.

5-Methyl-2-phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole[9c] (5u)

Obtained as a tan solid (164 mg, 79%). Mp: 212–214 °C. <span class="Chemical">1Hn> NMR (500.4 MHz, <span class="Chemical">CDCl3 with 1% TMS): δ 7.74–7.71 (m, <span class="Chemical">2H), 7.44–7.41 (m, 3H), 7.00 (dd, J = 7.9, 3.4 Hz, 1H), 6.94 (s, 1H), 6.79 (d, J = 7.9 Hz, 1H), 6.69 (s, 2H), 2.40 (d, J = 3.4 Hz, 3H). 13C NMR (125.8 MHz, CDCl3 with 1% TMS): δ 136.6, 134.2, 133.1, 129.8, 129.0, 128.3, 120.1, 112.0, 110.8, 21.5. 11B NMR (128.4 MHz, MeCN): δ 28.6. IR (neat): 3440, 3054, 2915, 1603, 1419, 805, 695, 569 cm–1. HMRS (CI) m/z: calcd for C13H14BN2 [M + H]+ 209.1250, found 209.1247.

5-Fluoro-2-phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (5v)

Obtained as a brown solid (160 mg, 76%). Mp: 186–188 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.73–7.70 (m, 2H), 7.47–7.41 (m, 3H), 6.98 (dd, J = 8.4, 4.9 Hz, 1H), 6.85 (dd, J = 9.3, 2.5 Hz, 1H), 6.78 (s, 1H), 6.71–6.66 (m, 2H). 13C NMR (125.8 MHz, CDCl3): δ 157.9 (d, J = 233.9 Hz), 136.9 (d, J = 11.9 Hz), 133.1, 132.6, 130.0, 128.4, 110.7 (d, J = 9.9 Hz), 105.8 (d, J = 24.1 Hz), 99.0 (d, J = 26.8 Hz). 11B NMR (128.4 MHz, MeCN): δ 29.2. 19F NMR (282.4 MHz, CDCl3): δ −124.9. IR (neat): 3441, 1424, 1365, 1255, 1139, 700, 587 cm–1. HMRS (CI) m/z: calcd for C12H11BN2F [M + H]+ 213.0999, found 213.1000.

5-Bromo-2-phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (5w)

Eight millimole scale reaction in a 20 mL microwave vial. Obtained as a brown solid (1.64 g, 76%). Mp: 157–159 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.77–7.63 (m, 2H), 7.45 (d, J = 6.0 Hz, 3H), 7.24 (s, 1H), 7.12–7.05 (m, 1H), 6.97 (d, J = 7.9 Hz, 1H), 6.77 (s, 2H). 13C NMR (125.8 MHz, CDCl3): δ 137.8, 135.5, 133.2, 130.2, 128.4, 122.2, 114.3, 112.2, 112.0. 11B NMR (128.4 MHz, MeCN): δ 28.8. IR (neat): 3435, 1599, 1420, 803, 697, 566 cm–1. HMRS (CI) m/z: calcd for C12H10BBrN2 [M]+ 272.0120, found 272.0127.

5-Phenylcarbonyl-2-phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (5x)

Eight millimole scale reaction in a 20 mL microwave vial. Product further purified via recrystallization from bn class="Chemical">oiln>ing toluene. Obtained as a burnt orange solid (1.31 g, 55%). Mp: 186–187 °C. 1H NMR (500.4 MHz, DMSO-d6): δ 9.68 (s, 1H), 9.44 (s, 1H), 7.96–7.85 (m, 2H), 7.74–7.66 (m, 2H), 7.66–7.59 (m, 1H), 7.58–7.51 (m, 3H), 7.45 (t, J = 4.6 Hz, 3H), 7.39 (dd, J = 8.1, 2.5 Hz, 1H), 7.19 (dd, J = 8.4, 2.8 Hz, 1H). 13C NMR (125.8 MHz, DMSO-d6): δ 195.4, 142.0, 139.0, 137.0, 133.5, 131.3, 129.8, 128.2, 128.0, 127.5, 122.7, 112.6, 110.3. 11B NMR (128.4 MHz, MeCN): δ 30.2. IR (neat): 3460, 3372, 1603, 1428, 1287, 707, 630 cm–1. HMRS (CI) m/z: calcd for C19H16BN2O [M + H]+ 299.1356, found 299.1348.

5-Nitro-2-phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole[9c] (5y)

Product further purified via recrystallization from bn class="Chemical">oiln>ing toluene. Obtained as an orange solid (148 mg, 62%). Mp: 195–196 °C. 1H NMR (500.4 MHz, DMSO-d6): δ 9.97 (s, 1H), 9.70 (s, 1H), 7.94–7.86 (m, 4H), 7.50–7.45 (m, 3H), 7.20 (d, J = 8.5 Hz, 1H). 13C NMR (125.8 MHz, DMSO-d6): δ 143.7, 139.8, 137.1, 133.6, 130.2, 128.1, 116.0, 110.1, 105.9. 11B NMR (128.4 MHz, MeCN): δ 31.0. IR (neat): 3435, 3415, 3380, 1610, 1435, 1303, 695, 631 cm–1. HMRS (ESI-) m/z: calcd for C12H9BN3O2 [M – H]− 238.0788, found 238.0788.

2-Phenyl-2,3-dihydro-1H-1,3,2-naphthodiazaborole[9c] (5z)

Product further purified via recrystallization from bn class="Chemical">oiln>ing toluene. Obtained as a tan solid (33.5 mg, 14%). Mp: > 250 °C. 1H NMR (500.4 MHz, DMSO-d6): δ 9.30 (s, 2H), 8.00–7.95 (m, 2H), 7.77 (dd, J = 6.6, 3.3 Hz, 2H), 7.48–7.44 (m, 3H), 7.42 (s, 2H), 7.22 (dd, J = 6.9, 3.1 Hz, 2H). 13C NMR (125.8 MHz, DMSO-d6): δ 139.0, 133.7, 129.9, 128.6, 128.0, 126.4, 122.0, 105.4. 11B NMR (128.4 MHz, MeCN): δ 30.8. IR (neat): 3429, 1435, 862, 695, 588 cm–1. HMRS (CI) m/z: calcd for C16H14BN2 [M + H]+ 245.1250, found 245.1252.

General Procedure for Synthesis of Alkyl and Alkenyl 1,3,2-Benzodiazaboroles 6a–h and 7a–h

n class="Chemical">Diaminen> (1 equiv, 1 mmol), organotrifluoroborate (1 equiv, 1 mmol), and BF3·NH2Et (3 equiv, 3 mmol) were placed in an oven-dried Biotage microwave vial with a stir bar. The vial was sealed with a cap, which was lined with a disposable Teflon septum. The reaction vessel was subsequently evacuated and purged three times with argon. A 1/1 mixture of CPME (1 mL) and toluene (1 mL) was added, and the reaction mixture was heated to 80 °C. After it was stirred overnight, the reaction mixture was diluted with 2 mL of hexane and run though a 2 in. silica plug, with 10% EtOAc in hexane as eluent. The reaction mixture was then condensed under vacuum to afford the azaborine compound.

(E)-2-(Prop-1-en-1-yl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (6a)

Obtained as a brown solid (110 mg, 70%). Mp: 72–74 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.05 (dd, J = 5.7, 3.3 Hz, 2H), 6.94 (dd, J = 5.8, 3.2 Hz, 2H), 6.60–6.33 (m, 3H), 5.90 (d, J = 17.7 Hz, 1H), 1.95 (d, J = 6.4 Hz, 3H). 13C NMR (125.8 MHz, CDCl3): δ 143.8, 136.3, 119.1, 110.9, 22.1. 11B NMR (128.4 MHz, CDCl3): δ 27.0. IR (neat): 3385, 3185, 1500, 1272, 743 cm–1. HMRS (CI) m/z: calcd for C9H12BN2 [M + H]+ 159.1094, found 159.1100.

2-(Cyclohex-1-en-1-yl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (6b)

Obtained as a brown solid (156 mg, 79%). Mp: 123–125 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.03 (dd, J = 5.6, 3.2 Hz, 2H), 6.92 (dd, J = 5.6, 3.2 Hz, 2H), 6.41 (s, 3H), 2.29–2.25 (m, 2H), 2.21–2.16 (m, 2H), 1.74–1.67 (m, 4H). 13C NMR (125.8 MHz, CDCl3): δ 138.0, 136.3, 119.0, 110.8, 27.3, 26.7, 22.8, 22.4. 11B NMR (128.4 MHz, CDCl3): δ 27.9. IR (neat): 3430, 2923, 2852, 1627, 1431, 738, 594 cm–1. HMRS (CI) m/z: calcd for C12H16BN2 [M + H]+ 199.1407, found 199.1411.

2-Vinyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (6c)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a tan solid (97 mg, 68%). Mp: 106–108 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.05 (dt, J = 7.3, 3.6 Hz, 2H), 6.94 (dd, J = 5.7, 3.2 Hz, 2H), 6.52 (s, 2H), 6.31 (dd, J = 20.0, J = 13.7 Hz, 1H), 6.08–5.85 (m, 2H). 13C NMR (125.8 MHz, CDCl3): δ 136.1, 131.8, 119.4, 111.1. 11B NMR (128.4 MHz, MeCN): δ 27.5. IR (neat): 3415, 3054, 1615, 1407, 1270, 954, 750, 631 cm–1. HMRS (CI) m/z: calcd for C8H9BN2 [M]+ 144.0859, found 144.0849.

2-(1-Propynyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (6d)

Obtained as a white solid (122 mg, 78%). Mp: 130–131 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.06–7.03 (m, 2H), 6.96 (dd, J = 5.7, 3.2 Hz, 2H), 6.59 (s, 2H), 2.02 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 135.5, 119.7, 111.2, 5.0. 11B NMR (128.4 MHz, MeCN): δ 20.2. IR (neat): 3422, 3057, 2204, 1418, 1352, 1266, 729, 624 cm–1. HMRS (CI) m/z: calcd for C9H9BN2 [M]+ 156.0859, found 156.0844.

1-Methyl-2-vinyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (6e)

Obtained as a n class="Chemical">darkn> red oil (136 mg, 86%). 1H NMR (500.4 MHz, CDCl3): δ 7.05 (d, J = 7.4 Hz, 1H), 7.02–6.99 (m, 2H), 6.96 (dt, J = 7.1, 2.7 Hz, 1H), 6.50 (s, 1H), 6.41 (dd, J = 18.6, 15.5 Hz, 1H), 5.98 (d, J = 18.6 Hz, 2H), 3.40, (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 135.8, 131.8, 119.2, 119.1, 110.7, 108.5, 29.5. 11B NMR (128.4 MHz, MeCN): δ 26.71. IR (neat): 3428, 3054, 2930, 1614, 1443, 1399, 1010, 733 cm–1. HMRS (CI) m/z: calcd for C9H12BN2 [M + H]+ 159.1094, found 159.1090.

(E)-1-Methyl-2-(prop-1-en-1-yl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (6f)

Obtained as a n class="Chemical">darkn> brown solid (153 mg, 89%). Mp: 81–85 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.02 (d, J = 7.5 Hz, 1H), 6.99 (d, J = 3.4 Hz, 2H), 6.94 (dd, J = 7.0, 4.3 Hz, 1H), 6.49–6.42 (dd, J = 18.0, 6.0 Hz, 1H), 6.40 (s, 1H), 5.98 (dd, J = 18.0, 1.8 Hz, 1H), 3.37 (s, 3H), 1.96 (dd, J = 6.0, 1.8 Hz, 3H). 13C NMR (125.8 MHz, CDCl3): δ 143.7, 138.9, 136.0, 118.9, 118.8, 110.4, 108.2, 29.4, 22.3. 11B NMR (128.4 MHz, MeCN): δ 27.0. IR (neat): 3424, 2905, 1645, 1412, 1240, 984, 733 cm–1. HMRS (CI) m/z: calcd for C10H14BN2 [M + H]+ 173.1250, found 173.1254.

1-Phenyl-2-vinyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (6g)

Ten millimole scale reaction in a 50 mL round-bottom flask. Product was further purified via combiflash with n class="Chemical">hexanen>/EtOAc as solvents. Obtained as a deep red oil (0.93 g, 42%). 1H NMR (500.4 MHz, CDCl3): δ 7.47 (t, J = 7.1 Hz, 2H), 7.40–7.29 (m, 3H), 7.13 (d, J = 7.7 Hz, 1H), 7.07 (d, J = 7.9 Hz, 1H), 7.01 (t, J = 7.4 Hz, 1H), 6.94 (t, J = 7.6 Hz, 1H), 6.70 (s, 1H), 6.25 (dd, J = 20.1, J = 13.9 Hz, 1H), 5.99–5.84 (m, 2H). 13C NMR (125.8 MHz, CDCl3): δ 140.6, 137.8, 135.7, 132.4, 129.4, 126.9, 120.1, 119.3, 111.3, 110.1. 11B NMR (128.4 MHz, MeCN): δ 26.7. IR (neat): 3430, 3054, 1596, 1396, 1269, 736, 696 cm–1. HMRS (CI) m/z: calcd for C14H14BN2 [M + H]+ 221.1250, found 221.1254.

(E)-1-Phenyl-2-(1-propenyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole (6h)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a red solid (178 mg, 76%). Mp: 61–63 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.53–7.43 (m, 2H), 7.40–7.29 (m, 3H), 7.13–7.08 (m, 1H), 7.08–7.03 (m, 1H), 7.03–6.97 (m, 1H), 6.96–6.90 (m, 1H), 6.59 (s, 1H), 6.49–6.34 (m, 1H), 5.84 (d, J = 18.9 Hz, 1H), 1.91–1.84 (m, 3H). 13C NMR (125.8 MHz, CDCl3): δ 144.5, 140.8, 138.0, 136.0, 129.3, 127.0, 125.9, 119.9, 119.1, 111.0, 109.8, 22.2. 11B NMR (128.4 MHz, CDCl3): δ 26.8. IR (neat): 3387, 1597, 1495, 1315, 746, 691 cm–1. HMRS (CI) m/z: calcd for C14H13BN2 [(M + H) – CH3]+ 220.1172, found 220.1172.

2-Methyl-2,3-dihydro-1H-1,3,2-benzodiazaborole[8b] (7a)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a tan solid (94 mg, 71%). Mp: 67–68 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.00 (dd, J = 5.7, 3.2 Hz, 2H), 6.91 (dd, J = 5.7, 3.2 Hz, 2H), 6.30, (s, 2H), 0.63 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 136.4, 118.9, 110.5. 11B NMR (128.4 MHz, CDCl3): δ 30.3. IR (neat): 3421, 3385, 3054, 2905, 1612, 1263, 739, 600 cm–1. HMRS (CI) m/z: calcd for C7H8BN2 [M – H]− 131.0781, found 131.0783.

2-Isopropyl-2,3-dihydro-1H-1,3,2-benzodiazaborole[8a] (7b)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4:1) as eluent. Obtained as a tan solid (107 mg, 67%). Mp: 78–79 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.07–6.97 (m, 2H), 6.94–6.86 (m, 2H), 6.31 (s, 2H), 1.52 (sept, J = 7.4 Hz, 1H), 1.15 (d, J = 6.7 Hz, 6H). 13C NMR (125.8 MHz, CDCl3): δ 136.2, 119.0, 110.8, 20.1. 11B NMR (128.4 MHz, CDCl3): δ 32.4. IR (neat): 3432, 3385, 3186, 2945, 1458, 1431, 1274, 738, 576 cm–1. HMRS (CI) m/z: calcd for C9H13BN2 [M]+ 160.1172 found 160.1177.

2-Cyclopropyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (7c)

Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a dark brown solid (90 mg, 57%). Mp: 64–66 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.01–6.94 (m, 2H), 6.92–6.86 (m, 2H), 6.15 (s, 2H), 0.82 (dt, J = 9.4, 3.8 Hz, 2H), 0.50 (dd, J = 6.6, 3.8 Hz, 2H), 0.21 (tt, J = 9.4, 6.3 Hz, 1H). 13C NMR (125.8 MHz, CDCl3): δ 136.3, 118.9, 110.5, 5.6. 11B NMR (128.4 MHz, MeCN): δ 31.2. IR (neat): 3414, 2998, 2925, 1440, 900, 733, 588 cm–1. HMRS (CI) m/z: calcd for C9H11BN2 [M]+ 158.1015, found 158.1008.

2-(tert-Butyl)-2,3-dihydro-1H-1,3,2-benzodiazaborole[8a] (7d)

Half millimole scale reaction. Product further purified via a plug of n class="Chemical">silican> with hexane/EtOAc (4/1) as eluent. Obtained as a tan solid (63 mg, 72%). Mp: 90–91 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.05–6.99 (m, 2H), 6.95–6.88 (m, 2H), 6.26 (s, 2H), 1.13 (s, 9H). 13C NMR (125.8 MHz, CDCl3): δ 136.2, 119.1, 110.8, 100.1, 29.1. 11B NMR (128.4 MHz, CDCl3): δ 33.08. IR (neat): 3438, 3390, 3345, 3194, 2939, 1477, 1435, 585, 568 cm–1. HMRS (CI) m/z: calcd for C10H15BN2 [M]+ 174.1328, found 174.1328.

2-Phenethyl-2,3-dihydro-1H-1,3,2-benzodiazaborole[25] (7e)

Obtained as a brown solid (198 mg, 89%). Mp: 112–114 °C. n class="Chemical">1Hn> NMR (500.4 MHz, CDCl3): δ 7.31 (t, J = 7.5 Hz, 2H), 7.27 (d, J = 1.4 Hz, 2H), 7.21 (t, J = 7.2 Hz, 1H), 7.00 (dd, J = 5.7, 3.2 Hz, 2H), 6.91 (dd, J = 5.7, 3.2 Hz, 2H), 6.29 (s, 2H), 2.90 (t, J = 8.1 Hz, 2H), 1.59 (t, J = 8.1 Hz, 2H). 13C NMR (125.8 MHz, CDCl3): δ 144.4, 136.2, 128.6, 128.1, 125.9, 119.0, 110.7, 32.0. 11B NMR (128.4 MHz, MeCN): δ 31.0. IR (neat): 3433, 2925, 1434, 1267, 732, 593 cm–1. HMRS (CI) m/z: calcd for C14H15BN2 [M]+ 222.1328, found 222.1328.

1,2-Dimethyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (7f)

Five millimole scale reaction in a 20 mL microwave vial. Obtained as a n class="Chemical">darkn> brown solid (0.66 g, 90%). Mp: 80–82 °C. 1H NMR (500.4 MHz, CDCl3): δ 7.04–6.96 (m, 3H), 6.96–6.90 (m, 1H), 6.29 (s, 1H), 3.31 (s, 3H), 0.65 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 138.8, 136.1, 118.7, 118.5, 110.1, 107.9, 29.2. 11B NMR (128.4 MHz, MeCN): δ 30.3. IR (neat): 3425, 3054, 2910, 1615, 1413, 1368, 1356, 732, 586 cm–1. HMRS (CI) m/z: calcd for C8H11BN2 [M]+ 146.1051, found 146.1021.

2-(3-Chloropropyl)-1-methyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (7g)

Obtained as a brown n class="Chemical">oiln> (194 mg, 94%). 1H NMR (500.4 MHz, CDCl3): δ 7.03–6.87 (m, 3H), 6.93 (dt, J = 6.93, 2.5 Hz, 1H), 6.26 (s, 1H), 3.60 (t, J = 6.7 Hz, 2H), 3.31 (s, 3H), 2.08–1.98 (m, 2H), 1.36 (t, J = 8.0 Hz, 2H). 13C NMR (125.8 MHz, CDCl3): δ 138.7, 135.9, 119.0, 118.8, 110.4, 108.2, 47.4, 29.3, 29.3. 11B NMR (128.4 MHz, CDCl3): δ 30.6. IR (neat): 3327, 2928, 1617, 1307, 1052, 910, 731 cm–1. HMRS (CI) m/z: calcd for C10H14BN2Cl [M]+ 208.0939, found 208.0939.

2-Methyl-1-phenyl-2,3-dihydro-1H-1,3,2-benzodiazaborole (7h)

Ten millimole scale reaction in a 50 mL round-bottom flask. Product was further purified via Combiflash with n class="Chemical">hexanen>/EtOAc as solvents. Obtained as a deep red oil (0.93 g, 32%). 1H NMR (500.4 MHz, CDCl3): δ 7.46 (t, J = 7.9 Hz, 2H), 7.37–7.28 (m, 3H), 7.06 (dt, J = 10.9, 7.9 Hz, 2H), 6.97 (t, J = 7.7 Hz, 1H), 6.91 (t, J = 7.7 Hz, 1H), 6.48 (s, 1H), 0.64 (s, 3H). 13C NMR (125.8 MHz, CDCl3): δ 141.0, 137.7, 136.0, 129.3, 126.6, 125.7, 119.6, 118.9, 110.7, 109.6. 11B NMR (128.4 MHz, MeCN): δ 30.6. IR (neat): 3433, 1597, 1409, 1356, 1271, 734, 697 cm–1. HMRS (CI) m/z: calcd for C13H14BN2 [M + H]+ 209.1250, found 209.1250.