| Literature DB >> 27070709 |
Christopher J Ricketts1, Daniel R Crooks1, Carole Sourbier1, Laura S Schmidt1, Ramaprasad Srinivasan1, W Marston Linehan1.
Abstract
Renal cell carcinoma (RCC) is a heterogeneous disease made up of a number of different cancer types, with distinct histologies, clinical courses, therapeutic responses, and genetic drivers. Germline mutations in 14 genes have been associated with increased risk of RCC and can result in HIF pathway activation, chromatin dysregulation, and altered metabolism. Knowledge of these pathway alterations can inform the development of targeted therapeutic approaches. To view this SnapShot, open or download the PDF.Entities:
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Year: 2016 PMID： 27070709 DOI： 10.1016/j.ccell.2016.03.021
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743