Literature DB >> 27070694

Targeting PI3K Signaling in Cancer: A Cautionary Tale of Two AKTs.

Jérôme Fortin1, Tak W Mak2.   

Abstract

AKT inhibitors represent promising therapeutics for cancers with PI3K-AKT pathway hyperactivation. In this issue of Cancer Cell, Wang et al. (2016) report the unexpected finding that ablation of AKT signaling in hepatocytes leads to hepatocellular carcinoma and enhances the incidence of lung metastases in a toxin-induced liver cancer model.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27070694     DOI： 10.1016/j.ccell.2016.03.020

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  11 in total

1.  The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of the PI3K/Akt/mTOR/NF-κB axis.

Authors:  Maged W Helmy; Asser I Ghoneim; Mohamed A Katary; Rana K Elmahdy
Journal:  Mol Biol Rep       Date:  2020-02-22       Impact factor: 2.316

Review 2.  The Antibiotic Drug Tigecycline: A Focus on its Promising Anticancer Properties.

Authors:  Zhijie Xu; Yuanliang Yan; Zhi Li; Long Qian; Zhicheng Gong
Journal:  Front Pharmacol       Date:  2016-12-02       Impact factor: 5.810

3.  Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.

Authors:  Liang Sun; Pi-Bao Li; Yan-Fen Yao; Ai-Yuan Xiu; Zhi Peng; Yu-Huan Bai; Yan-Jing Gao
Journal:  World J Gastroenterol       Date:  2018-03-14       Impact factor: 5.742

4.  The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.

Authors:  Qiong Wu; Jin-Xian Chen; Yu Chen; Li-Li Cai; Xiao-Zhong Wang; Wu-Hua Guo; Jian-Feng Zheng
Journal:  Cell Death Dis       Date:  2018-02-14       Impact factor: 8.469

Review 5.  Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level.

Authors:  Saeid Doaei; Maryam Gholamalizadeh; Mohammad Esmaeil Akbari; Shayan Akbari; Hyuliya Feradova; Ghazaleh Rahimzadeh; Alireza Mosavi Jarrahi
Journal:  Malays J Med Sci       Date:  2019-04-30

6.  SPP1 overexpression is associated with poor outcomes in ALK fusion lung cancer patients without receiving targeted therapy.

Authors:  Xiaolin Ji; Yan Liu; Fang Mei; Xinyang Li; Mengxue Zhang; Buwen Yao; Rui Wu; Jiangfeng You; Fei Pei
Journal:  Sci Rep       Date:  2021-07-07       Impact factor: 4.379

7.  XB130 Knockdown Inhibits the Proliferation, Invasiveness, and Metastasis of Hepatocellular Carcinoma Cells and Sensitizes them to TRAIL-Induced Apoptosis.

Authors:  Guang-Ming Li; Chao-Jie Liang; Dong-Xin Zhang; Li-Jun Zhang; Ji-Xiang Wu; Ying-Chen Xu
Journal:  Chin Med J (Engl)       Date:  2018-10-05       Impact factor: 2.628

Review 8.  Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review.

Authors:  Ashok Kumar Pandurangan; Thomas Divya; Kalaivani Kumar; Vadivel Dineshbabu; Bakthavatchalam Velavan; Ganapasam Sudhandiran
Journal:  World J Gastrointest Oncol       Date:  2018-09-15

9.  TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway.

Authors:  Wenqing Tang; Bei Lv; Biwei Yang; Yukai Chen; Feifei Yuan; Lijie Ma; She Chen; Si Zhang; Jinglin Xia
Journal:  Oncogenesis       Date:  2019-01-25       Impact factor: 7.485

10.  Dysregulated long non‑coding RNAs in pleomorphic adenoma tissues of pleomorphic adenoma gene 1 transgenic mice.

Authors:  Wanlin Xu; Limin Liu; Hao Lu; Jinye Fu; Chenping Zhang; Wenjun Yang; Shukun Shen
Journal:  Mol Med Rep       Date:  2019-04-11       Impact factor: 2.952
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