Literature DB >> 27069511

Quantitative reactive modeling and verification.

Thomas A Henzinger1.   

Abstract

Formal verification aims to improve the quality of software by detecting errors before they do harm. At the basis of formal verification is the logical notion of correctness, which purports to capture whether or not a program behaves as desired. We suggest that the boolean partition of software into correct and incorrect programs falls short of the practical need to assess the behavior of software in a more nuanced fashion against multiple criteria. We therefore propose to introduce quantitative fitness measures for programs, specifically for measuring the function, performance, and robustness of reactive programs such as concurrent processes. This article describes the goals of the ERC Advanced Investigator Project QUAREM. The project aims to build and evaluate a theory of quantitative fitness measures for reactive models. Such a theory must strive to obtain quantitative generalizations of the paradigms that have been success stories in qualitative reactive modeling, such as compositionality, property-preserving abstraction and abstraction refinement, model checking, and synthesis. The theory will be evaluated not only in the context of software and hardware engineering, but also in the context of systems biology. In particular, we will use the quantitative reactive models and fitness measures developed in this project for testing hypotheses about the mechanisms behind data from biological experiments.

Entities:  

Keywords:  Embedded systems; Formal methods; Program verification; Systems biology

Year:  2013        PMID: 27069511      PMCID: PMC4811300          DOI: 10.1007/s00450-013-0251-7

Source DB:  PubMed          Journal:  Comput Sci (Berl)        ISSN: 1865-2034


  5 in total

1.  Computational insights into Caenorhabditis elegans vulval development.

Authors:  Jasmin Fisher; Nir Piterman; E Jane Albert Hubbard; Michael J Stern; David Harel
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-31       Impact factor: 11.205

2.  Symbolic reachable set computation of piecewise affine hybrid automata and its application to biological modelling: Delta-Notch protein signalling.

Authors:  R Ghosh; C Tomlin
Journal:  Syst Biol (Stevenage)       Date:  2004-06

Review 3.  Executable cell biology.

Authors:  Jasmin Fisher; Thomas A Henzinger
Journal:  Nat Biotechnol       Date:  2007-11       Impact factor: 54.908

Review 4.  Petri net modelling of biological networks.

Authors:  Claudine Chaouiya
Journal:  Brief Bioinform       Date:  2007-07-11       Impact factor: 11.622

Review 5.  Two challenges in embedded systems design: predictability and robustness.

Authors:  Thomas A Henzinger
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2008-10-28       Impact factor: 4.226

  5 in total

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