Literature DB >> 2706938

A basic phospholipase A from the venom of the Australian king brown snake (Pseudechis australis) showing diverse activities against membranes.

P J Sharp1, S L Berry, I Spence, M E Howden.   

Abstract

1. A basic phospholipase A (MSPA) was isolated from the venom of the Australian king brown snake, Pseudechis australis. 2. MSPA had an approximate Mr of 13,000 and consisted of a single polypeptide chain of 119 amino acid residues cross-linked by seven disulphide bridges. 3. MSPA exhibited direct haemolytic, anticoagulant and myotoxic activities. 4. Treatment of MSPA with p-bromophenacyl bromide modified a single histidine residue, resulting in complete loss of enzyme activity.

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Year:  1989        PMID: 2706938     DOI: 10.1016/0305-0491(89)90123-5

Source DB:  PubMed          Journal:  Comp Biochem Physiol B        ISSN: 0305-0491


  3 in total

1.  A pan-specific antiserum produced by a novel immunization strategy shows a high spectrum of neutralization against neurotoxic snake venoms.

Authors:  Kavi Ratanabanangkoon; Kae Yi Tan; Kritsada Pruksaphon; Chaiya Klinpayom; José María Gutiérrez; Naeem H Quraishi; Choo Hock Tan
Journal:  Sci Rep       Date:  2020-07-09       Impact factor: 4.379

2.  High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.

Authors:  Julien Slagboom; Marija Mladić; Chunfang Xie; Taline D Kazandjian; Freek Vonk; Govert W Somsen; Nicholas R Casewell; Jeroen Kool
Journal:  PLoS Negl Trop Dis       Date:  2020-04-01

3.  The detoxifying effects of structural elements of persimmon tannin on Chinese cobra phospholipase A2 correlated with their structural disturbing effects well.

Authors:  Ying Zhang; Chun-Mei Li
Journal:  J Food Drug Anal       Date:  2016-11-03       Impact factor: 6.157

  3 in total

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