Literature DB >> 27069322

Hyperhomocysteinemia, MMPs and Cochlear Function: A Short Review.

Seema Bhargava1, Meghaa Shanta Bhargava2, Eishaan Kamta Bhargava3, L M Srivastava1.   

Abstract

Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented.

Entities:  

Keywords:  Cochlea; Hearing loss; Hyperhomocysteinemia; MMPs; TIMPs

Year:  2015        PMID： 27069322      PMCID： PMC4820424          DOI： 10.1007/s12291-015-0505-1

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  22 in total

1.  Collagenolytic activity in amphibian tissues: a tissue culture assay.

Authors:  J GROSS; C M LAPIERE
Journal:  Proc Natl Acad Sci U S A       Date:  1962-06-15       Impact factor: 11.205

2.  Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis.

Authors:  S L Leib; D Leppert; J Clements; M G Täuber
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

Review 3.  Matrix metalloproteinases and the regulation of tissue remodelling.

Authors:  Andrea Page-McCaw; Andrew J Ewald; Zena Werb
Journal:  Nat Rev Mol Cell Biol       Date:  2007-03       Impact factor: 94.444

Review 4.  The emerging role of proteases in retinal ganglion cell death.

Authors:  Shravan K Chintala
Journal:  Exp Eye Res       Date:  2005-09-26       Impact factor: 3.467

5.  Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo.

Authors:  Nicholas Shukeir; Pouya Pakneshan; Gaoping Chen; Moshe Szyf; Shafaat A Rabbani
Journal:  Cancer Res       Date:  2006-09-15       Impact factor: 12.701

6.  Matrix metalloproteinase inhibitor attenuates cochlear lateral wall damage induced by intratympanic instillation of endotoxin.

Authors:  Cheol Hee Choi; Chul Ho Jang; Yong Bum Cho; Si Young Jo; Min Young Kim; Byung Young Park
Journal:  Int J Pediatr Otorhinolaryngol       Date:  2012-02-11       Impact factor: 1.675

7.  Matrix imbalance by inducing expression of metalloproteinase and oxidative stress in cochlea of hyperhomocysteinemic mice.

Authors:  Soumi Kundu; Neetu Tyagi; Utpal Sen; Suresh C Tyagi
Journal:  Mol Cell Biochem       Date:  2009-07-10       Impact factor: 3.396

8.  Prevalence of hyperhomocysteinemia in vascular disease: comparative study of thrombotic venous disease vis-à-vis occlusive arterial disease.

Authors:  Seema Bhargava; Rajiv Parakh; Anjali Manocha; Arif Ali; Lalit Mohan Srivastava
Journal:  Vascular       Date:  2007 May-Jun       Impact factor: 1.285

9.  Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation.

Authors:  Melvin R Hayden; Suresh C Tyagi
Journal:  Nutr J       Date:  2004-05-10       Impact factor: 3.271

10.  Dexamethasone inhibits interleukin-1β-induced matrix metalloproteinase-9 expression in cochlear cells.

Authors:  Sung-Il Nam; Taeg-Kyu Kwon
Journal:  Clin Exp Otorhinolaryngol       Date:  2014-08-01       Impact factor: 3.372
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  1 in total

1.  Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas.

Authors:  Alina van Dieken; Hinrich Staecker; Heike Schmitt; Jennifer Harre; Andreas Pich; Willi Roßberg; Thomas Lenarz; Martin Durisin; Athanasia Warnecke
Journal:  Front Cell Dev Biol       Date:  2022-04-28
  1 in total

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