Stefan Janssen1, Lukas Kaesmann2, Steven E Schild3, Dirk Rades4. 1. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany. 2. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 3. Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A. 4. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
Abstract
AIM: To compare three total radiation dose levels for their impact on survival in patients receiving palliative radiotherapy (RT) for locally advanced lung cancer. PATIENTS AND METHODS: Radiation dose (equivalent dose in 2 Gy fractions=EQD2: 31-40 Gy vs. 41-46 Gy vs. 47-52 Gy), completion of RT as planned, plus nine factors were analyzed for survival in 125 patients. RESULTS: On multivariate analysis, EQD2 47-52 Gy (p=0.018), completion of planned RT (p=0.002), lower T-category (p=0.027) and lower N-category (p=0.008) were positively associated with survival. Thirty-six patients (29%) could not receive the complete planned RT dose, 19% in the 31-40 Gy group, 36% in the 41-46 Gy group and 31% in the 47-52 Gy group, respectively. Six-month survival rates of these patients were 0%, 18% and 18%, respectively. CONCLUSION: Higher RT doses resulted in significantly better survival than lower doses. The favorable results were impaired when the planned treatment could not be completed. Copyright
AIM: To compare three total radiation dose levels for their impact on survival in patients receiving palliative radiotherapy (RT) for locally advanced lung cancer. PATIENTS AND METHODS: Radiation dose (equivalent dose in 2 Gy fractions=EQD2: 31-40 Gy vs. 41-46 Gy vs. 47-52 Gy), completion of RT as planned, plus nine factors were analyzed for survival in 125 patients. RESULTS: On multivariate analysis, EQD2 47-52 Gy (p=0.018), completion of planned RT (p=0.002), lower T-category (p=0.027) and lower N-category (p=0.008) were positively associated with survival. Thirty-six patients (29%) could not receive the complete planned RT dose, 19% in the 31-40 Gy group, 36% in the 41-46 Gy group and 31% in the 47-52 Gy group, respectively. Six-month survival rates of these patients were 0%, 18% and 18%, respectively. CONCLUSION: Higher RT doses resulted in significantly better survival than lower doses. The favorable results were impaired when the planned treatment could not be completed. Copyright
Authors: T S Lewis; J A Kennedy; G J Price; T Mee; D K Woolf; N A Bayman; C Chan; J H Coote; C Faivre-Finn; M A Harris; A M Hudson; L S Pemberton; A Salem; H Y Sheikh; H B Mistry; D C P Cobben Journal: Clin Oncol (R Coll Radiol) Date: 2020-06-26 Impact factor: 4.126