Literature DB >> 27068830

Effect of morroniside on glomerular mesangial cells through AGE-RAGE pathway.

Gaohong Lv1, Xing Lv1, Yuhan Tao1, Huiqin Xu2,3.   

Abstract

Diabetes mellitus is an endocrine and metabolic disease characterized by high blood glucose. Diabetic nephropathy (DN) is one of the most typical diabetic complications. Cornus officinalis is a type of traditional Chinese medicine that replenishes the liver and kidney. Morroniside is one of the main characteristic components of C. officinalis. In this study, an in vitro model for simulating DN damage was established by stimulating rat glomerular mesangial cells by the advanced glycation end products. The protective mechanism and effect of morroniside in regulating receptor for advanced glycation end products signaling pathway in DN was investigated to provide experimental evidence for the prevention and treatment of DN.

Entities:  

Keywords:  AGE–RAGE pathway; Diabetic nephropathy; Glomerular mesangial cells; Morroniside

Mesh：

Substances：

Year:  2016        PMID： 27068830     DOI： 10.1007/s13577-015-0128-0

Source DB:  PubMed          Journal:  Hum Cell        ISSN： 0914-7470            Impact factor:   4.174


  17 in total

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Authors:  A Taguchi; D C Blood; G del Toro; A Canet; D C Lee; W Qu; N Tanji; Y Lu; E Lalla; C Fu; M A Hofmann; T Kislinger; M Ingram; A Lu; H Tanaka; O Hori; S Ogawa; D M Stern; A M Schmidt
Journal:  Nature       Date:  2000-05-18       Impact factor: 49.962

2.  Nanosize titanium dioxide cause neuronal apoptosis: a potential linkage between nanoparticle exposure and neural disorder.

Authors:  Yiqun Yu; Wenwen Ren; Baozhong Ren
Journal:  Neurol Res       Date:  2008-12       Impact factor: 2.448

3.  Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice.

Authors:  Chan Hum Park; Jeong Sook Noh; Takashi Tanaka; Takako Yokozawa
Journal:  J Pharm Pharmacol       Date:  2010-03       Impact factor: 3.765

4.  RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin.

Authors:  Khin-Mar Myint; Yasuhiko Yamamoto; Toshio Doi; Ichiro Kato; Ai Harashima; Hideto Yonekura; Takuo Watanabe; Harumichi Shinohara; Masayoshi Takeuchi; Koichi Tsuneyama; Noriyoshi Hashimoto; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Hiroshi Yamamoto
Journal:  Diabetes       Date:  2006-09       Impact factor: 9.461

5.  Advanced glycation end products promote human aortic smooth muscle cell calcification in vitro via activating NF-κB and down-regulating IGF1R expression.

Authors:  Yi Wang; Zhen-yu Zhang; Xiao-qing Chen; Xiang Wang; Heng Cao; Shao-wen Liu
Journal:  Acta Pharmacol Sin       Date:  2013-02-18       Impact factor: 6.150

Review 6.  Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy.

Authors:  C Hu; L Sun; L Xiao; Y Han; X Fu; X Xiong; X Xu; Y Liu; S Yang; F Liu; Y S Kanwar
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Review 7.  Pimagedine: a novel therapy for diabetic nephropathy.

Authors:  Emaad Abdel-Rahman; W Kline Bolton
Journal:  Expert Opin Investig Drugs       Date:  2002-04       Impact factor: 6.206

8.  Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats.

Authors:  Takako Yokozawa; Noriko Yamabe; Hyun Young Kim; Ki Sung Kang; Jong Moon Hur; Chan Hum Park; Takashi Tanaka
Journal:  Biol Pharm Bull       Date:  2008-07       Impact factor: 2.233

9.  Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.

Authors:  Xian Jin; Tongqing Yao; Zhong'e Zhou; Jian Zhu; Song Zhang; Wei Hu; Chengxing Shen
Journal:  Biomed Res Int       Date:  2015-05-31       Impact factor: 3.411

10.  Fast automated yeast cell counting algorithm using bright-field and fluorescence microscopic images.

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Journal:  Biol Proced Online       Date:  2013-11-11       Impact factor: 3.244
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  4 in total

1.  Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.

Authors:  Jian Zhang; Qiqiang Zhang; Xiaofei Chen; Yan Liu; Jiyang Xue; Arik Dahan; Hai Zhang; Yifeng Chai
Journal:  Evid Based Complement Alternat Med       Date:  2018-04-26       Impact factor: 2.629

Review 2.  Cornus mas and Cornus Officinalis-Analogies and Differences of Two Medicinal Plants Traditionally Used.

Authors:  Monika E Czerwińska; Matthias F Melzig
Journal:  Front Pharmacol       Date:  2018-08-28       Impact factor: 5.810

3.  XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy.

Authors:  Yan Wang; Zhong He; Qiu Yang; Guangju Zhou
Journal:  FEBS Open Bio       Date:  2019-06-02       Impact factor: 2.693

Review 4.  Active Components and Pharmacological Effects of Cornus officinalis: Literature Review.

Authors:  Xue Gao; Yi Liu; Zhichao An; Jian Ni
Journal:  Front Pharmacol       Date:  2021-04-12       Impact factor: 5.810
  4 in total

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